Biosensors MDPI’s Post

#Review Overview of Liquid Crystal Biosensors: From Basic Theory to Advanced Applications by Ruixiang Qu, et al. https://lnkd.in/e8DsmbJx MDPI #liquidcrystal #biosensor #opticalsensing #activeopticalcomponents #openaccess #Abstract Liquid crystals (LCs), as the remarkable optical materials possessing stimuli-responsive property and optical modulation property simultaneously, have been utilized to fabricate a wide variety of optical devices. Integrating the LCs and receptors together, LC biosensors aimed at detecting various biomolecules have been extensively explored. Compared with the traditional biosensing technologies, the LC biosensors are simple, visualized, and efficient. Owning to the irreplaceable superiorities, the research enthusiasm for the LC biosensors is rapidly rising. As a result, it is necessary to overview the development of the LC biosensors to guide future work. This article reviews the basic theory and advanced applications of LC biosensors. We first discuss different mesophases and geometries employed to fabricate LC biosensors, after which we introduce various detecting mechanisms involved in biomolecular detection. We then focus on diverse detection targets such as proteins, enzymes, nucleic acids, glucose, cholesterol, bile acids, and lipopolysaccharides. For each of these targets, the development history and state-of-the-art work are exhibited in detail. Finally, the current challenges and potential development directions of the LC biosensors are introduced briefly.

If you truly understood the power of what the molecules in ASEA REDOX do in your body, you would never want to be without ASEA REDOX. DID YOU KNOW that people often describe the experience as a "miracle"? But it's just science. ASEA REDOX contains trillions of BIOACTIVE REDOX CELL SIGNALING MOLECULES in every bottle. Certified and guaranteed. Your own cells make these molecules and they are critical for advancing life. But most of us no longer make enough for vibrant, problem-free health. Creating a supplement was a medical dream! DID YOU KNOW that it was a dream considered impossible? ASEA achieved it when they completed a process that took over 17 years to perfect. The process has 7 patents and over 300 manufacturing secrets! First, reverse osmosis and deionization are used to make one of the purest waters on the planet. The Megatron system constantly runs 200 gallons of water per minute in a loop under UV light removing all bacteria and impurities, officially classifying it as "ultra-pure". ASEA mixes that with salt and takes it through the revolutionary process that creates BIOACTIVE REDOX SIGNALING MOLECULES. This is how ASEA REDOX is created. Each batch takes several days. Reputable, international third-party labs put their seals of guarantee on each bottle certifying that cell signaling molecules are present as claimed. DID YOU KNOW that scientists at universities worldwide are stunned when they perform studies on it? Try it yourself with someone to guide you and experience your own miracle!

#Review Recent Advances in Biomolecular Detection Based on Aptamers and Nanoparticles by Ruiting Xu, Leixin Ouyang, Heyi Chen, Ge Zhang and Jiang Zhe https://lnkd.in/dBZKPVtE   #MDPI #Biomolecular #Aptamers #Nanoparticles #biosensors #sensors #openaccess   #Abstract The fast, accurate detection of biomolecules, ranging from nucleic acids and small molecules to proteins and cellular secretions, plays an essential role in various biomedical applications. These include disease diagnostics and prognostics, environmental monitoring, public health, and food safety. Aptamer recognition (DNA or RNA) has gained extensive attention for biomolecular detection due to its high selectivity, affinity, reproducibility, and robustness. Concurrently, biosensing with nanoparticles has been widely used for its high carrier capacity, stability and feasibility of incorporating optical and catalytic activity, and enhanced diffusivity. Biosensors based on aptamers and nanoparticles utilize the combination of their advantages and have become a promising technology for detecting of a wide variety of biomolecules with high sensitivity, reliability, specificity, and detection speed. Via various sensing mechanisms, target biomolecules have been quantified in terms of optical (e.g., colorimetric and fluorometric), magnetic, and electrical signals. In this review, we summarize the recent advances in and compare different aptamer–nanoparticle-based biosensors by nanoparticle types and detection mechanisms. We also share our views on the highlights and challenges of the different nanoparticle-aptamer-based biosensors.

If you truly understood the power of what the molecules in ASEA REDOX do in your body, you would never want to be without ASEA REDOX. DID YOU KNOW that people often describe the experience as a "miracle"? But it's just science. ASEA REDOX contains trillions of BIOACTIVE REDOX CELL SIGNALING MOLECULES in every bottle. Certified and guaranteed. Your own cells make these molecules and they are critical for advancing life. But most of us no longer make enough for vibrant, problem-free health. Creating a supplement was a medical dream! DID YOU KNOW that it was a dream considered impossible? ASEA achieved it when they completed a process that took over 17 years to perfect. The process has 7 patents and over 1,000 trade secrets! First, reverse osmosis and deionization are used to make one of the purest waters on the planet. The Megatron system constantly runs 200 gallons of water per minute in a loop under UV light removing all bacteria and impurities, officially classifying it as "ultra-pure". ASEA mixes that with salt and takes it through the revolutionary process that creates BIOACTIVE REDOX SIGNALING MOLECULES. This is how ASEA REDOX is created. Each batch takes several days. Reputable, international third-party labs put their seals of guarantee on each bottle certifying that cell signaling molecules are present as claimed. DID YOU KNOW that scientists at universities worldwide are stunned when they perform studies on it? Try it yourself with someone to guide you and experience your own miracle.

If you truly understood the power of what the molecules in ASEA REDOX do in your body, you would never want to be without ASEA REDOX. DID YOU KNOW that people often describe the experience as a "miracle"? But it's just science. ASEA REDOX contains trillions of BIOACTIVE REDOX CELL SIGNALING MOLECULES in every bottle. Certified and guaranteed. Your own cells make these molecules and they are critical for advancing life. But most of us no longer make enough for vibrant, problem-free health. Creating a supplement was a medical dream! DID YOU KNOW that it was a dream considered impossible? ASEA achieved it when they completed a process that took over 17 years to perfect. The process has 7 patents and over 1,000 trade secrets! First, reverse osmosis and deionization are used to make one of the purest waters on the planet. The Megatron system constantly runs 200 gallons of water per minute in a loop under UV light removing all bacteria and impurities, officially classifying it as "ultra-pure". ASEA mixes that with salt and takes it through the revolutionary process that creates BIOACTIVE REDOX SIGNALING MOLECULES. This is how ASEA REDOX is created. Each batch takes several days. Reputable, international third-party labs put their seals of guarantee on each bottle certifying that cell signaling molecules are present as claimed. DID YOU KNOW that scientists at universities worldwide are stunned when they perform studies on it? Try it yourself with someone to guide you and experience your own miracle.

Faster, Simpler, Stronger: Discover MIRA's Edge Over LAMP! 🔍 Traditional isothermal amplification methods, like LAMP (Loop-mediated Isothermal Amplification), have long been relied upon for nucleic acid detection due to their capability to amplify DNA at a constant temperature. While effective, LAMP and similar techniques come with their downsides. These include complex operations, high risks of aerosol contamination, and long wait times. They are not always ideal for on-the-spot, rapid detection, particularly in resource-limited environments. Amp Future’s MIRA (Multienzyme Isothermal Rapid Amplification) technology addresses these challenges with a suite of innovative features that elevate nucleic acid detection to new heights. MIRA is engineered for speed, accuracy, and simplicity, offering an amplification time as short as 5-20 minutes—a significant improvement over traditional isothermal methods that can take upwards of 1.5-2 hours. This rapid turnaround, paired with an impressive detection sensitivity of 1-5 copies/µL, positions MIRA as an exceptional choice for precise, fast diagnostics. Unlike conventional techniques that often require advanced equipment and trained personnel, MIRA is designed for minimal reliance on specialized tools. It operates at 39-42℃ constant temperature with low aerosol contamination risks and supports versatile reagent formats such as lyophilized powders and microspheres, which can be stored and transported more conveniently. Results can be presented through multiple formats, including agarose gel electrophoresis, fluorescence, or even simple test strips, with visualized results on portable devices, making it adaptable for various field conditions and laboratory needs. #AmpFuture #MIRA #EarlyDetection #MolecularDiagnostics #HealthInnovation

Prof. Hana Bisker Gili has developed a fluorometric method utilizing near-infrared (NIR) fluorescent SWCNT probes functionalized with myristoylcholine (MC), allowing real-time monitoring of cholinesterase (CHE) activity in blood plasma. The fluorescence of SWCNTs decreases upon CHE hydrolysis of MC, serving as optical sensors for enzyme activity in the NIR range. This approach offers advantages over UV-visible methods due to NIR's biological transparency and the background-free monitoring capabilities of SWCNTs. To learn more about this technology and its potential applications, please contact Noam Greenspoon, VP of Business Development in Physical Sciences at Ramot: noam.greenspoon@ramot.org #innovation #realtimemonitoring #plasma #enzymeactivity #research #researchinnovation

VWR Nano spectroscopy

The light in the dark: what you can see from single cells in turbid or opaque media Single-cell analysis is predominantly performed with instruments based on optical methods. Turbidity, opacity, and the occurrence of autofluorescence from the media under investigation can have a detrimental effect on the measurement result or even completely prevent a measurement. Obviously, you can’t see in the dark.   Impedance Flow Cytometry (IFC) proves to be the alternative in this case.  IFC measures electrical cell properties and is not based on optical methods. The presence of turbidity, opacity, or autofluorescence therefore has no impact on the measurement.   Typical applications are: - Turbid solutions: highly concentrated cell suspensions in fermentation - Opaque media: determination of somatic cells in milk or bacterial contaminations in emulsions - Auto-fluorescent media: measurement of microalgae producing metabolites like lipids   Interested in how it works with cell analysis in turbid, opaque, or auto-fluorescent media? More information you can find here: https://lnkd.in/esv6767J      #flowcytometry #cellanalysis #algae #emulsion

🔬Cell Free Riboswitches Engineering and Applications | Webinar Recording🔬 We are excited to announce that the webinar from last October is now available for viewing. This insightful session is accessible to all interested viewers! [Description] Cell-free systems aim to capture some properties and functions of living cells without using living cells. By building cell-free systems such as artificial cells and cell-free metabolic pathways, one can try to understand how cells work and/or exploit unique functions of cells without complexities associated with using living cells. In this webinar, we describe cell-free “riboswitches” as molecular devices that enable cell-free systems to sense chemical signals and respond by regulating protein production. Watch this webinar to learn about cell-free riboswitches, their development using microfluid droplet sorting and their role in intercellular communication. Speaker:  Yohei Yokobayashi, PhD, Professor, Nucleic Acid Chemistry and Engineering Unit, Okinawa Institute of Science and Technology Go to webinar page (Registration required): https://lnkd.in/ggWB7sxm #GeneticEngineering #CellSignaling #Genomics #RNA #Proteomics #Cells #mRNA