Boston Micro Fabrication - BMF’s Post

#Review 3D and 4D Printing in the Fight against Breast Cancer by Sofia Moroni, Luca Casettari  and Dimitrios A. Lamprou https://lnkd.in/e3zgCdNE MDPI Queen's University Belfast University of Urbino #3Dprinting #4Dprinting #additivemanufacturing #drugdelivery #breastcancer #openaccess #Abstract Breast cancer is the second most common cancer worldwide, characterized by a high incidence and mortality rate. Despite the advances achieved in cancer management, improvements in the quality of life of breast cancer survivors are urgent. Moreover, considering the heterogeneity that characterizes tumors and patients, focusing on individuality is fundamental. In this context, 3D printing (3DP) and 4D printing (4DP) techniques allow for a patient-centered approach. At present, 3DP applications against breast cancer are focused on three main aspects: treatment, tissue regeneration, and recovery of the physical appearance. Scaffolds, drug-loaded implants, and prosthetics have been successfully manufactured; however, some challenges must be overcome to shift to clinical practice. The introduction of the fourth dimension has led to an increase in the degree of complexity and customization possibilities. However, 4DP is still in the early stages; thus, research is needed to prove its feasibility in healthcare applications. This review article provides an overview of current approaches for breast cancer management, including standard treatments and breast reconstruction strategies. The benefits and limitations of 3DP and 4DP technologies are discussed, as well as their application in the fight against breast cancer. Future perspectives and challenges are outlined to encourage and promote AM technologies in real-world practice.

🧬 3D-Printed Bone Models: A Breakthrough in Cancer Research Innovation meets ethics! Low-cost 3D-printed bone models made from PLGA and hydroxyapatite are mimicking natural bone tissue, providing researchers with a controlled environment to study cancer cell behavior. Why It Matters: 📉 Cost-Effective: Reduces research expenses. 🐾 Ethical Alternative: Minimizes reliance on animal testing. 🧪 Advancing Science: Enables better understanding of breast cancer metastasis. This breakthrough highlights how technology is driving smarter, more sustainable approaches to healthcare research. More here 👉 https://buff.ly/4gkIvVg Let’s discuss: How do you see 3D printing transforming the future of medicine? ⬇️ #CancerResearch #3DPrinting #Deeptech #Innovation #Healthcare #EthicalResearch #Biotech #FutureOfMedicine

It's a big late, but I'm thrilled to belong to popular cited article throughout 2023 from SLAS technology. #SLASTECHNOLOGY The article provides a concise overview of the smart material mechanism in 4D printing and its promising role in cancer therapeutics. Huge thanks again to Ali Zolfagharian, Wiwat Nuansing, coauthors, and contributors for their support! Check it out here: https://lnkd.in/gh6ge4uv #4dprinting #cancer #3dprinting #additivemanufacturing

🌟 New research highlight 🌟 Title: Biofabrication and Monitoring of a 3D Printed Skin Model for Melanoma Authors: Vazquez-Aristizabal, P; Henriksen-Lacey, M; Garcia-Astrain, C; Jimenez de Aberasturi, D; Langer, J; Epelde, C; Litti, L; Liz-Marzan, LM; Izeta, A Journal: Adv. Healthcare Mat. 2024. DOI: 10.1002/adhm.202401136 There is an unmet need for in vitro cancer models that emulate the complexity of human tissues. 3D-printed solid tumor micromodels based on decellularized extracellular matrices (dECMs) recreate the biomolecule-rich matrix of native tissue. Herein a 3D in vitro metastatic melanoma model that is amenable for drug screening purposes and recapitulates features of both the tumor and the skin microenvironment is described. Epidermal, basement membrane, and dermal biocompatible inks are prepared by means of combined chemical, mechanical, and enzymatic processes. Bioink printability is confirmed by rheological assessment and bioprinting, and bioinks are subsequently combined with melanoma cells and dermal fibroblasts to build complex 3D melanoma models. Cells are tracked by confocal microscopy and surface-enhanced Raman spectroscopy (SERS) mapping. Printed dECMs and cell tracking allow modeling of the initial steps of metastatic disease, and may be used to better understand melanoma cell behavior and response to drugs. More info 👉 https://lnkd.in/dEmm5Vut #3Dbioprinting #melanoma #biofabrication #SERS Centro de Investigación Biomédica en Red CIBER Wiley

Don’t miss this upcoming event if you want to learn about how to transform #cancer care through #innovation in pediatrics. 👏 This event brings together surgeons, biomedical engineers, and 3D printing experts to explore the latest in oncology surgery, including 3D surgical planning, tissue printing, 3D printing technology, and virtual reality. 💯 1⃣ Organized by: 3DSurgHELP & funded by Plan Complementario de Biotecnología Aplicada a la Salud. 2⃣ Co-financed by the Spanish Ministry of Science, Innovation and Universities with funds from the European Union NextGenerationEU, from the Recovery, Transformation and Resilience Plan. 📅 November 14th 🕑 9 h 📍 CIM UPC 🔗 Register now! Limited places: https://lnkd.in/dj-mtsCD #PERTE_Salud Plan de Recuperación, Transformación y Resiliencia Ministerio de Ciencia, Innovación y Universidades #PlanDeRecuperación #NextGenerationEU

🌟 𝗥𝗲𝗽𝗹𝗶𝗾𝘂𝗲 𝗵𝗲𝗹𝗽𝘀 𝗺𝗼𝘃𝗶𝗻𝗴 𝗰𝗮𝗻𝗰𝗲𝗿 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵!🌟   We’re proud to support the Kolibri Project of the Childhood Cancer Center at Universitätsmedizin Mainz by sponsoring custom 𝟯𝗗 𝗽𝗿𝗶𝗻𝘁𝗲𝗱 𝘀𝗲𝗻𝘀𝗼𝗿 𝗵𝗼𝗹𝗱𝗲𝗿𝘀. 🚀   The Kolibri Project is dedicated to research and promote exercise therapy in order to empower young patients in their fight against cancer.   We have designed the 3D printed holders specifically for young patients, enhancing comfort and ensuring precise tracking during the exercise.   𝗞𝗲𝘆 𝗛𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀: ❇ 𝗖𝘂𝘀𝘁𝗼𝗺 𝗗𝗲𝘀𝗶𝗴𝗻 Durable, comfortable, and easy to disinfect ❇ 𝗖𝗵𝗶𝗹𝗱-𝗙𝗿𝗶𝗲𝗻𝗱𝗹𝘆 𝗖𝗼𝗹𝗼𝗿𝘀 Several colors to make therapy more engaging ❇ 𝗘𝗻𝗵𝗮𝗻𝗰𝗲𝗱 𝗗𝗮𝘁𝗮 𝗖𝗼𝗹𝗹𝗲𝗰𝘁𝗶𝗼𝗻 Improved compliance, longer wear times, and better return rates for measurements   In addition, we’re thrilled to have contributed 3D printed medals for the FORTEe project, providing extra motivation and recognition for the young patients.    This EU-wide initiative, involving 16 partners from eight countries, focuses on enabling and motivating exercise for children and adolescents with cancer.   As Elias Dreismickenbecker, a research associate at the Childhood Cancer Center Mainz, concludes:    “This is an especially challenging time for the children. Exercise and motivation can play a crucial role in their well-being and quality of life. That’s why I’m particularly glad that the introduction of the medals provides an additional boost of motivation for the kids.”   Read more about the project here 👉 https://lnkd.in/e-3dThqG   #3DPrinting #HealthTech #FORTEe #Innovation #EFHAM2024

Raising Awareness for Sarcoma: Our Commitment at 3D-Side 🎗️ This July, at 3D-Side, we stand together in support of Sarcoma Awareness Month, an important time to bring attention to this often overlooked cancer. As experts in computer-assisted surgical planning, our goal is to make a meaningful impact in sarcoma treatment. Sarcoma presents unique challenges in oncology. Therefore, we focus on personalized solutions aimed at enhancing surgical precision. Through advanced modeling and our expertise in 3D printing, we provide valuable support to medical teams, striving to optimize outcomes for patients. Beyond technical expertise, we collaborate closely with healthcare professionals and organizations to promote research, raise awareness, and support patients throughout their healthcare journey. Together, we aim to push boundaries and improve the quality of life for those affected by sarcoma. Join us in raising awareness for Sarcoma Awareness Month. Together, let's amplify our voices to support those in need and continue progressing towards more personalized care. #SarcomaAwareness #3DSide #QualityCare

3D Nanostructures for Tissue Engineering, Cancer Therapy, and Gene Delivery The self-assembling is a spontaneous progression through which objects of nanophase/molecules materialize into prepared collections. Several biomolecules can interact and assemble into highly structured supramolecular structures, for instance, proteins and peptides, with fibrous scaffolds, helical ribbons, and many other functionalities. Various self-assembly systems have been established, from copolymers in blocks to three-dimensional (3D) cell culture scaffolds. Another advantage of self- assembly is its ability to manage a large variety of materials, including metals, oxides, inorganic salts, polymers, semiconductors, and various organic semiconductors. The most basic self-assembly of 3D nanomaterials is three primary forms of nanostructured carbon-based materials that perform a critical role in the progress of modern nanotechnologies, such as carbon nanotubes (CNTs), graphene, and fullerene. This review summarized important information on the 3D self-assembly nanostructure, such as peptide hydrogel, graphene, carbon nanotubes (CNTs), and fullerene for application in gene delivery, cancer therapy, and tissue engineering. https://lnkd.in/d-yD3rQ

Facile and rapid fabrication of a novel 3D-printable, visible light-crosslinkable and bioactive polythiourethane for large-to-massive rotator cuff tendon repair. Facile and rapid 3D fabrication of strong, bioactive materials can address challenges that impede the repair of large-to-massive rotator cuff tears, including personalized grafts, limited mechanical support, and inadequate tissue regeneration. Herein, a facile and rapid methodology that generates visible light-crosslinkable polythiourethane (PHT) pre-polymer resin (∼30 min at room temperature), yielding 3D-printable scaffolds with tendon-like mechanical attributes capable of delivering tenogenic bioactive factors, was developed. Ex vivo characterization confirmed successful fabrication, robust human supraspinatus tendon (SST)-like tensile properties (strength: 23 MPa, modulus: 459 MPa, at least 10,000 physiological loading cycles without failure), excellent suture retention (8.62-fold lower than acellular dermal matrix (ADM)-based clinical graft), slow degradation, and controlled release of fibroblast growth factor-2 (FGF-2) and transforming growth factor-β3 (TGF-β3). In vitro studies showed cytocompatibility and growth factor-mediated tenogenic-like differentiation of mesenchymal stem cells. In vivo studies demonstrated biocompatibility (3-week mouse subcutaneous implantation) and the ability of growth factor-containing scaffolds to notably regenerate at least 1 cm of tendon with native-like biomechanical attributes as uninjured shoulder (8-week large-to-massive 1cm gap rabbit rotator cuff injury). This study demonstrates the use of a 3D-printable, strong, and bioactive material to provide mechanical support and pro-regenerative cues for challenging injuries such as large-to-massive rotator cuff tears. https://lnkd.in/gcN8Hx9c