Bowman Bagley’s Post

Probing the anti-fibrotic effect of umbilical cord mesenchymal stem cell-derived exosomes: Mengling Song, Rong Hu and collaborators at Ningxia Medical University investigated the impact of umbilical cord mesenchymal stem cell-derived exosomes (UCMSC-exo) on endometrial fibrosis and explored the potential involvement of the miR-140-3p/FOXP1/Smad axis in the anti-fibrotic properties of UCMSC-exo https://lnkd.in/e4FYQbYd They observed that the ability of UCMSC-exo to combat fibrosis in human endometrial stromal cells was partially mediated by the miR-140-3p/FOXP1/Smad axis. An article also authored by @Lijun Ma, Yongzhao Zhu and @Huimin Gao #extracellularvesicles #exosomes #biomarkers #stemcells #flowcytometry #Vesiculab

Enhancing spinal cord repair with bioengineered exosomes from induced pluripotent stem cells: in their latest article, Azar Abbas at SHENZHEN INSTITUTE OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES, Kun Zeng at Jinan University and collaborators aimed to develop engineered exosomes derived from induced pluripotent stem cells (iPSCs-Exo) capable of targeting and supporting neurons, and to evaluate their therapeutic potential in promoting spinal cord injury recovery. In vivo biodistribution of the engineered iPSC-Exo was tracked using a live imaging system, and results showed that miRNA-loaded iPSC-Exo significantly enhanced recovery https://lnkd.in/evbSbWpv Comprehensive safety assessments, including Hematoxylin and Eosin staining of major organs, showed no signs of systemic toxicity, with normal organ histology and biochemical profiles following iPSC-Exo administration. An article co-authored by Xiaosheng Huang, Aftab Ullah, Lishi Luo, Wenqun Xi and Yuanjiao Qiao #extracellularvesicles #exosomes #stemcells #bioengineering #miRNA #Vesiculab

WEBINAR: Advances in iPSC Workflows to Build Better Models and Therapies Join us at our upcoming webinar to explore innovations in stem cell workflows and 3D disease models! Learn about iPSC characterization, suspension culture, and advanced differentiation techniques. Plus, discover how to leverage novel protocols for neural, cardiac, and hemopoietic organoid models. ##gibco ##ipsc ##ipscresearch #workflow

Join us at our upcoming webinar to explore innovations in stem cell workflows and 3D disease models! Learn about iPSC characterization, suspension culture, and advanced differentiation techniques. Plus, discover how to leverage novel protocols for neural, cardiac, and hemopoietic organoid models. #thermofisheremp

Join us at our upcoming webinar to explore innovations in stem cell workflows and 3D disease models! Learn about iPSC characterization, suspension culture, and advanced differentiation techniques. Plus, discover how to leverage novel protocols for neural, cardiac, and hemopoietic organoid models. #thermofisheremp

It's the last day to learn how to increase stem cell reprogramming and differentiation efficiency and homogeneity at #SfN2024! Stop by booth 1305 to pick up your copy of the scientific poster "Accelerating the Use of Patient-Derived hiPSC Neuronal Models by Increasing Efficiency of Reprogramming and Differentiation Using CellRaft Technology." https://hubs.la/Q02RSd4L0 #stemcells #diseasemodels #biomedical

Ah, Mesenchymal Stem Cells (MSCs)—the true polymaths of the cell world. They can morph into various cell types, calm the immune system, heal wounds, and support blood and vessel formation. Quite the show-offs, really.   Enter Atelerix with its innovation: CytoStor. This clever tech lets MSCs be stored at room temperature—no freezing fuss—and keeps them in tip-top shape. With CytoStor, your MSCs retain: Viability Differentiation talent Wound-healing prowess Blood and vessel support skills Intrigued? Want to see it in action? Get in touch or request a sample. Your MSCs deserve it.

We are looking forward to the next event of the 2024 REGENHU webinar series! 📅 Date: Apr 23 🕚 Time: 10:00 EDT / 16:00 CET 👉 Register here: https://lnkd.in/d8kcRvKp Dr. Ruchi Sharma, Senior Staff Scientist at the National Eye Institute (NEI) of The National Institutes of Health and supervisor of the 3D bioprinting research activities in the Ocular and Stem Cell Translational Research Section directed by Dr. Kapil Bharti, will give a talk titled "3D-Bioprinted Vascularized Eye Tissue for Patient-Specific In-Vitro Models". During her talk, Dr. Sharma will present an overview of the research activities performed by her group to engineer in-vitro models of age-related macular degeneration by combining IPSCs-derived, tissue-specific cell types through 3D bioprinting. Don’t miss out on this opportunity to learn more about the huge potential of 3D bioprinting for the development of physiologically relevant in-vitro models of healthy and diseased tissues for drug testing and novel patient-specific therapies. #Bioprinting #Biofabrication #InVitroModels #DiseaseModels  #PersonalizedMedicine #DrugDiscovery  #EyeTissue #Retina #MacularDegeneration #Vascularization

Join us at our upcoming webinar to explore innovations in stem cell workflows and 3D disease models! Learn about iPSC characterization, suspension culture, and advanced differentiation techniques. Plus, discover how to leverage novel protocols for neural, cardiac, and hemopoietic organoid models. #thermofisheremp

Join us at our upcoming webinar to explore innovations in stem cell workflows and 3D disease models! Learn about iPSC characterization, suspension culture, and advanced differentiation techniques. Plus, discover how to leverage novel protocols for neural, cardiac, and hemopoietic organoid models. #thermofisheremp