CarboHyde’s Post

✅ In their recent publication, Eduardo F. Mizobuchi and Antonio Burtoloso showcase a new method for synthesis of 1,3-dicarbonyl sulfoxonium ylides. 🔬 Their acylation reaction is carried out under mild conditions using inexpensive and bench-stable N-hydroxyphthalimide esters as acylating agents. 🧪 The reactions proceed via a non-radical, transition-metal-free pathway, and the corresponding products are obtained in yields of up to 85%. 👀 Read more here: https://lnkd.in/eCv4AU_M

This paper reports an N-1 selective Pd-catalyzed cross-coupling of dihydrouracil with aryl halides to provide access to relevant scaffolds in a single step

Synthesis of Sulfonyl amidines under mild conditions ... Eur. J. Org. Chem., Early View https://lnkd.in/g54wEm9M

Happy to share our latest results, now published in the Org. Biomol. Chem! Congratulations to the team. We disclosed the strategies of an efficient Cu(OTf )2-catalyzed [3 + 2] cycloaddition of indole-3- acrylate with p-benzoquinone has been developed to construct two distinct indole-tethered benzofuran scaffolds, offering the first-ever selective access to these scaffolds. Moreover, the [4 + 2] cycloaddition reaction of indole-3-acrylate with vinyl ketone derivatives was used to synthesize carbazoles in a one-pot manner. #indole #cycloaddition #organicchemistery https://lnkd.in/gWsp9yaA

Our total synthesis of lappaceolides A and B is now on ChemRXiv as a preprint (https://lnkd.in/eT7fvtDa). A biomimetic vinylogous-Michael–oxa-Michael domino dimerization reaction constructs both the natural products in a single step from siphonodin! While it looks simple when you see it written out, the domino reaction required intense optimization to arrive at the said reaction conditions.

Alkyl- and Acyl-Derivatives of Copsinine and Pseudocopsinine and Their Crystal Structures https://lnkd.in/dnbC2JMd

After a long way I really happy to share my latest paper in Angew. Chem. Int. Ed. In this contribution we found out how Ene-Reductases are able to reduce alkynes to the corresponding alkenes with high selectivity. Also this methodology offers a safety improvement over traditional methods based on high hydrogen pressures or harsh conditions. https://lnkd.in/d2dPe5pP

It is my pleasure to share with you my new paper entitled: "Temperature Dependence of the Polar and Lewis Acid–Base Properties of Poly Methyl Methacrylate Adsorbed on Silica via Inverse Gas Chromatography". https://lnkd.in/e6UTgrkP

Stunning work from Ben Cravatt's lab with Bruno Melillo & Stuart Schreiber in the Journal of the American Chemical Society on the proteomic discovery of stereochemically defined spirocyclic azetidine acrylamides as #covalent degraders of the ERCC3 helicase! Beautiful structures, and a fascinating mechanism of action! https://lnkd.in/gC8xajQV An interesting note: these spirocyclic azetidine acrylamides are significantly less reactive than the Cravatt lab's previously reported monocyclic azetidine acrylamide stereoprobes. This could represent a broadly useful strategy for medicinal chemists looking to attenuate the disproportionately high electrophilicity of azetidine acrylamides arising from their distorted nonplanar hybridization and reduced amide character. https://lnkd.in/g7kzt_qQ

🚨 Excited to share our latest work! 🚨 🔬 Preprint Alert: Total Synthesis of Cafestol from ent-Kaurenoic Acid is now live! This project highlights a novel synthetic route to cafestol, a bioactive diterpene found in coffee. ✨ Key Highlights: 🔹 Developed a unique one-pot oxa-Michael Wittig annulation to construct the furan ring. 🔹 Efficient 19-step total synthesis starting from stevioside, a natural sweetener, and 14 steps from ent-kaurenoic acid. 🔹 Innovative approach offers potential for analog synthesis and biological studies. 📄 Read the full preprint here: https://lnkd.in/gCC5imTJ Supp. Info.:https://lnkd.in/gxWqtqFn #OrganicChemistry #NaturalProducts #TotalSynthesis #DrugDiscovery #SyntheticChemistry