CellCelector - Single Cell, Colony or Organoid Selection and Retrieval’s Post

It gives me immense joy to share the news of our recent publication: Selective Segregation of Thermo-Responsive Microgels via Microfluidic Technology. This paper is especially dear to me as it was one of my last projects during my PhD, which is now brought to fruition by my colleagues/dearest friends. I thank them deeply for their continued support and faith in this work. Shout out to Marek Bekir and Daniela Vasquez! The paper talks about an elegant solution of selectively segregating similar sized microgels of different charges using a combined effect of pressure-driven microfluidic flow and precise temperature control. Read more about how thermo-responsive mirogels undergo a volume phase transition change during heating, causing them to shrink and correspondingly changing their drift along a pressure driven shear flow, allowing for their selective control and segregation: https://lnkd.in/eSB6-qCi

Foam Mitigation in Bioreactors Using Ultrasound A U.S. Patent for "Foam Mitigation in Bioreactors Using Ultrasound" was awarded to Sartorius on June 4th, 2024. The present invention is a bioreactor with at least one coupling element provided on the casing for coupling with a foam mitigation device for mitigation of foam built-up in the interior space of the bioreactor during use of the bioreactor for culturing of microorganisms or cells; wherein the coupling element is configured to allow ultrasonic waves generated by the foam mitigation device act upon foam built-up in the interior space of the bioreactor. https://lnkd.in/gGp_U_8P #aspenalert #biotech #bioprocess

The world of single-cell analysis is revolutionizing our understanding of complex biological processes. However, isolating and manipulating individual cells can be a tedious and error-prone task. Enter the Tecan UNO Single Cell Dispenser, a game-changer for researchers seeking a high-throughput, precise, and gentle solution for their single-cell workflows. The UNO leverages microfluidics technology to deliver controlled, single-cell dispensing into various well plates. This eliminates the time-consuming and potentially damaging process of manual cell isolation. The beauty lies in its versatility. The UNO offers a range of cassette options, accommodating a broad spectrum of cell types and sizes. Whether your research involves surfactant-free or surfactant-requiring environments, the UNO has you covered. Crucially, the gentle dispensing process ensures high cell viability (>90% with C1a Cassettes), preserving the health of your precious cells for downstream experiments. Explore how the Tecan UNO can elevate your single-cell workflows and visit this article, https://lnkd.in/dq_dmGAB, to learn more! #Tecan #SingleCell #Science #Research #Innovation

Small Forces, Big Impact! 🔬 Introducing NANBIOSIS Unit 12 services (part 5):💧 #SurfaceTension At NANBIOSIS Unit 12, we measure surface and interfacial tension to study how molecules interact at liquid interfaces. Using advanced tools like the Sigma 701 tensiometer, we unlock insights for industries like healthcare, nanotech, and more. From analyzing pure liquids to complex solutions, this helps design innovative materials and solutions. ✨ Explore how science bridges microforces and macroscopic breakthroughs! 🔗 Surface and interfacial tensiometry service: https://lnkd.in/dD6GdRn3 🔗 Surface hydrophobicity characterization service: https://lnkd.in/duYpvquN Also available in our YouTube channel! https://lnkd.in/dSEvX8vi #NanbiosisExpertise #CEBS #CEBiomedS

🔬 Exciting News! Our latest collaboration with ZELLMECHANIK DRESDEN is revolutionizing droplet analysis in microfluidics. By combining our Fluidic 537 (or any other droplet generator design) with ZELLMECHANIK DRESDEN's advanced DeCellerator device and RecoTeem software, we're enabling real-time monitoring of droplet parameters like never before. 💧💧💧 Plus, with the integration of FLUIGENT Deutschland GmbH pump systems, a feedback loop can be incorporated for dynamic control. Learn more about this technology: https://lnkd.in/eDQsHYRU Here are just a few other application possibilities: 1️⃣ Quality assurance: Ensure consistency by monitoring droplet variations. 2️⃣ Chemical Synthesis and Pharma: Optimize reaction conditions in real-time by tracking rapid mixing and reaction processes. 3️⃣ Sorting and Analysis: Utilize high-speed imaging for rapid cell sorting and characterization. 4️⃣ Bubble Flow Regulation: Gain insights into bubble dynamics for improved flow regulation and oxygen transfer. 5️⃣ Lab Automation: Enhance fluid transport optimization for advanced lab automation and diagnostics. 6️⃣ High-Throughput Screening: Accelerate drug discovery with high-throughput screening applications. Contact us for more information: inquiries@microfluidic-ChipShop.com. #Microfluidics #DropletAnalysis #Innovation #LabonaChip

Check out our recent installation of Dolomite's cutting-edge Telos system for high-throughput production of microdroplets, microparticles, or emulsions. Equipped with 10 microfluidic chips powering up to 70 channels, it truly is in a league of its own. Transitioning from the finely-tuned, precise droplet generation of Dolomite's single-channel systems to large-scale manufacturing, the Telos system transforms workflows for research up to production. It's the preferred tool for driving advancements in drug discovery, encapsulation, particle synthesis, material science, biological research, and diagnostics development. Intrigued? Explore further on https://lnkd.in/eZseiqnq #microfluidics #particles #emulsions #drugdiscovery #encapsulation #materialsscience

Featured on the inside front cover of issue 15 of #NanoscaleAdvances! 'Bio-inspired synthesis of N-doped TiO2/C nanocrystals using jellyfish mucus with high visible-light photocatalytic efficiency' by Song Feng, Lingchen Liu, Jianing Lin, Bin Zhang et al. Check out the full article here ⬇ https://lnkd.in/edQm-h3i

Happy to share our latest publication led by our PhD student James Johnston and Hyunsu Jeon at ND Chemical and Biomolecular Engineering in Biomaterials Science – recognized as an Emerging Investigator article! Small extracellular vesicles (sEVs) are emerging as nanocarriers in drug delivery, but scaling their production for clinical applications remains a challenge. In our new work, we tackle this problem with a novel 3D culture platform that significantly boosts sEV production. 💡 Key innovation: We developed a piezoelectric nanofibrous scaffold (PES), coupled with acoustic stimulation, to mimic a natural 3D microenvironment. This platform led to a 15.7-fold increase in sEV production per cell, with particle size and protein composition consistent with standard methods. 🔬 How it works: 3D cell culture + acoustic stimulation synergize to activate key pathways involved in sEV production. Cell morphology shifts in 3D lead to cytoskeleton redistribution and enhanced intracellular vesicle trafficking. Many thanks to our collaborators who contributed to this work, and to Biomaterials Science for recognizing us with the Emerging Investigator honor. Read more: https://lnkd.in/ghXcMr2v #DrugDelivery #Biomaterials #ExtracellularVesicles #3DCellCulture #EmergingInvestigator #ScientificInnovation #Biotech #BiomedicalScience

𝐌𝐚𝐬𝐭𝐞𝐫𝐢𝐧𝐠 𝐂𝐨𝐦𝐩𝐥𝐞𝐱 𝐏𝐚𝐭𝐭𝐞𝐫𝐧𝐬: Custom Liquid Dispensing on Biochips Our pipetting system demonstrates how complex and custom structures can be mapped on biochips – with pinpoint accuracy. Regardless of the required shape or pattern, our pipette precisely follows the desired structures, dispensing defined volumes every time. This technology allows for the exact application of specific volumes, enabling even arbitrary designs on biochips. It offers a clear advantage for applications where reliability and reproducibility in liquid handling are critical. Discover how our solution opens up new possibilities for microfluidics and biochip research! #microdrop #LifeSciences #Biochips #CustomDispensing #Efficiency #Microfluidics

Today is National Metric Day! Every year on 10/10, the metric system is celebrated for being the measurement system based on powers of 10. It's the most used measurement system in the world, with just a few holdouts using the Imperial system. Even in the Imperial United States, the metric system is predominant in the fields of science, technology, energy, healthcare, and pharmaceuticals, among others. #WhySoImperial You can observe the metric system today by measuring in meters, drinking in liters, and weighing in kilograms... and behold the power of 10! #NationalMetricDay #MASTest #MaterialsTesting Image description: A grayscale micrograph taken using a scanning electron microscope, showing more than 70 spherical particles that each measure about 1 micrometer.