CellSave Arabia’s Post

An interesting study coming out of Thailand. Cannabidiol suppresses proliferation and induces cell death, autophagy and senescence in human cholangiocarcinoma cells via the PI3K/AKT/mTOR pathway while this is a bit thicker in context. It is apparent after running various models the team was able to deduce the likelihood of cbd to kill off select cells and promote new cell development.  https://lnkd.in/dfjMDzzu

Enterococcus may worsen colitis by activating specific adrenergic receptors via its metabolite Tyramine. [Mouse][preclinical research][interventional] NOTES: - α2A-adrenergic receptor (#ADRA2A) as a highly expressed #GPCR in intestinal stem cells (ISCs). - #Tyramine, primarily produced by #Enterococcus via #Tyrosine_decarboxylase (tyrDC), serves as a microbial ligand for ADRA2A. - Enterococcus-derived Tyramine suppresses ISC proliferation, thereby impairing epithelial regeneration and exacerbating DSS-induced #Colitis through ADRA2A. - blocking the axis with an ADRA2A antagonist, #yohimbine, disrupts Tyramine-mediated suppression on ISCs and alleviates Colitis. https://lnkd.in/e7Jf8TQq

Recently, I participated in clinical research training for a phase III study of givinostat in polycythemia vera (PV). Givinostat represents an innovative approach to PV treatment, differing from standard therapies like hydroxycarbamide. It targets cell proliferation by inhibiting cells with the JAK2 V617F mutation, prevalent in PV patients. Early phase trials have shown givinostat's effectiveness, even in patients unresponsive to hydroxycarbamide, highlighting its potential as an alternative or supplementary treatment for PV. Looking forward to the advancements this could bring to the CMPN patients! #ClinicalTrials #Research #PolycythemiaVera #Givinostat

Product Citation: StressMarq's Anti #Beclin-1 Antibody (SPC-600) was used in a new study examining mitochondrial #DNA deletions & cellular responses in the presence of oxidative phosphorylation complexes. SPC-600 🔎 https://bit.ly/3xkwZsp Paper 📖 https://bit.ly/4aiu1mI

Happy to share our latest collaboration paper in Cell Death & Differentitaion! The study by Anahita Ofoghi from Alexander Bartelt‘s lab provides new insights into ferroptosis and reveals how the DDI2-NFE2L1 pathway within the ubiquitin-proteasome system is crucial in regulating this process. #CellDeath #ferroptosis #ubiquitin #proteomics #ubiquitomics

We're thrilled to announce our presence at the #EBMT European CAR T-cell meeting in Valencia, Spain on 15 -17 February 2024 – Our partners from the Banc de Sang i Teixits will be presenting original research on "Factors Affecting CD3+ Collection Efficiency in Nonmobilized Donors for the Manufacture of Commercial Chimeric Antigen Receptor T Cells." Join us for this insightful poster presentation. In the meantime, dive into the Quintessential Role of Apheresis in Gene-modified T-cell Therapy. Leukapheresis, the removal of white blood cells, is a vital step in production, and we'll explore its efficiency influenced by factors like patient disease state, treatment protocol, age, peripheral blood counts including CD3+, product cell counts, apheresis- and device/alarms - parameters. Read more here: https://bit.ly/3OFi8hT #GeneTherapy #TCellTherapy #Apheresis #MedicalInnovation#CAR-T#CD3 #CE2 #MedicalResearch #HealthcareScience #Transplant #EBMT24 #CellularTherapy #CART24 The EBMT

🥼 🔬 🧪 Paper of the Day ❗ ❗ ❗ Activating the NFE2L1-ubiquitin-proteasome system         by DDI2 protects from ferroptosis A Paper of the Day deals with a study published in Cell Death & Differentiation sheds light on the complex interplay between ferroptosis, a type of cell death, and the NFE2L1-ubiquitin-proteasome system. The researchers found that ferroptosis can lead to the activation of NFE2L1, a transcription factor involved in regulating the proteasome, a cellular machinery responsible for protein degradation. This feedback loop helps cells cope with oxidative stress and prevent further damage. The study also identifies DD12, an aspartyl protease, as a key regulator of this process. DD12 is responsible for cleaving NFE2L1, which is essential for its activation. Disrupting the DD12-NFE2L1 pathway sensitizes cells to ferroptosis, suggesting that targeting this pathway could be a potential therapeutic strategy. #cancer #cancerresearch #drugdiscovery #therapeuticstrategies #molecularbiology #cellularphysiology #lifeandscience #researchupdate #scienceoninstagram #ferroptosis #celldeath #NFE2L1 #ubiquitinproteasome #oxidativestress #proteasome #cellbiology #biochemistry #Scienceoflives #health #worldhealthorganization #Researcharticle #Openaccess #SOL #Scienceoflives #Scienceoflife #Biologicalprocess link to today's paper - https://lnkd.in/g3pBmr2U Date: 15/10/2024 For more, click the link below https://lnkd.in/gmJuz4eC

Check out Today's Paper of the Day!!!! #cancer #cancerresearch #drugdiscovery #therapeuticstrategies #molecularbiology #cellularphysiology #lifeandscience #researchupdate #scienceoninstagram #ferroptosis #celldeath #NFE2L1 #ubiquitinproteasome #oxidativestress #proteasome #cellbiology #biochemistry #Scienceoflives #health #worldhealthorganization #Researcharticle #Openaccess #SOL #Scienceoflives #Scienceoflife #Biologicalprocess

The formation of new blood vessels through angiogenesis is a complex and multi-step process. But what are the key events, and how is each step regulated? In our latest blog on in vitro angiogenesis, we explore the critical steps of blood vessel formation, from endothelial cell activation and proliferation to migration and tube formation. Explore the key events in angiogenesis, read our blog post: https://hubs.li/Q02zXf570

Lipoprotein a directed therapies 📌Zerlasiran: the new kid on the block: Short Interfering RNA Targeting Lipoprotein(a) 📌Phase 1 randomized study 📌4-8 week subcutaneous doses 📌Sustained ⬇️ lipoprotein(a) concentrations 📌No safety concerns 📌Further trial phases on their way Other drugs that reduce Lp(a) levels: PCSK9i (alirocumab, evolocumab) Inclisiran Olparisan Pelacarsen Recaticimab SLN360 Muvalaplin Bempedoic acid Lepodisiran #ACC24 #lipidology #cardiovascularrisk #riskprofile #residualrisk #physicalexercise #exerciseprescription #icosapentodeetilo #ethylicosapent #oceandose #smallRNA #rnatherapies #crisp #lbct #i+d+i #reguklatorymedicine #FDA #EMEA #AEMs #kol #keynotespeaker