Jaron Gladstone’s Post

Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells 🧬🧪🧫 https://lnkd.in/gWYsUq6H

#TechnologyTuesday 𝐓𝐑𝐒𝐛𝐚𝐢𝐭 – 𝐑𝐍𝐀-𝐦𝐢𝐦𝐢𝐜𝐫𝐲 𝐨𝐟 𝐯𝐢𝐫𝐚𝐥 𝐭𝐫𝐚𝐧𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐨𝐫 𝐚𝐬 𝐚𝐧𝐭𝐢𝐯𝐢𝐫𝐚𝐥 𝐝𝐫𝐮𝐠 The lack of a universal agent against the entire family of #nidovirales, including SARS-CoV-2, poses a major #challenge in the development of effective #treatments for #viral #infections. 💡 The #TRSbait technology invented at Helmholtz-Zentrum für Infektionsforschung (HZI) offers a promising solution, utilizing an #RNA #oligonucleotide in high abundance as a bait for the highly conserved TRS-binding site of the RNA-dependent RNA polymerase (#RdRp). By saturating the RdRp-TRS-binding site, #TRSbait effectively prevents viral TRS from binding, leading to a #reduction or even #inhibition of viral transcription. 👨🔬 Inventors: Luka Cicin-Sain & Ulfert Rand 🔎 Learn more about this #new #technology on our website: https://lnkd.in/e28jivrQ #Antiviral #UniversalAgent #RNAtechnology #Virology #SARSCoV2

Aberrant non-canonical NF-κB signalling reprograms the epigenome landscape to drive oncogenic transcriptomes in multiple myeloma The downstream molecular mechanisms following the activation of the NF-κB pathway in multiple myeloma (MM) remain to be characterised. Here, it is shown that aberrant non-canonical NF-κB signalling causes epigenomic reprogramming leading to transcriptional changes that favour MM progression. https://lnkd.in/gUi3bYYP

molecular mechanisms of estrogen receptor deregulation via synthetic estrogen and antiestrogen treatment, helped to reveal the omnipotent curing capacity of endogenous estrogens via balanced liganded and unliganded activation of estrgen receptors.

MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB https://lnkd.in/gqnpt6Va

Amygdalin (vitamin B17) as a Promising Anticancer Agent: Molecular Mechanisms and Future Perspectives for the Development of New Nanoformulations for Its Delivery.

Transposon exonization, the inclusion of transposable element sequences in mRNA, generates a decoy receptor isoform of IFNAR2 that inhibits interferon signaling, revealing a primate-specific mechanism for immune regulation. #epigenetics https://lnkd.in/gb7E6GhZ

As a cell culture media fanatic, its great to see how one (normal) raw material in a cell culture media can make your cell therapeutic, in this case, CAR-T, more effective and persistent. #galactose #cellculturemedia #CART #persistent https://lnkd.in/gC7nUWMP

CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8+ T cell formation https://lnkd.in/g3vm-cVe

Recognition of the molecular mechanisms of estrogen receptor deregulation via synthetic estrogen and antiestrogen treatment, helped to reveal the omnipotent curing capacity of endogenous estrogens via balanced liganded and unliganded activation of estrgen receptors.