CHANDRAJEET DHARA’s Post

Great tools to study immuneresponse!

Explore our human M1/M2 macrophage polarization in vitro assay. A well-defined in vitro model to test the effect of drug-candidates on the M1/M2 balance!

We will be exhibiting at the Nanomedicine and Drug Delivery Symposium in Orlando, Sept. 13-15, 2024. The annual event serves as an important gathering for researchers developing next-generation delivery vehicles — targeted, responsive, biodegradable nanomaterials to make diagnostics more sensitive and drugs more effective. PreciGenome's NanoGenerator will be on display over the course of the three days. These high-performance instruments for nanoparticle synthesis such as lipid nanoparticles, liposomes, PLGA, etc. are widely used for drug delivery, gene therapy, LNP formulation, manufacturing, etc. Check out my blog post https://wix.to/ExXztCp Visit our website for more information about NanoGenerator LNP synthesis systems. #nanoDDS #drugdelivery #lipidnanoparticles #nanoparticles #drugdiscovery #mrna #formulation #cdmo #cro #pharmaceuticals #therapeutics #PCR #microfluidics #droplet

Check out our new PPI inhibitor screen

The article “3-Alkoxy-1-Benzyl-5-Nitroindazole Derivatives Are Potent Antileishmanial Compounds" has now been published in International Journal of Molecular Sciences MDPI as part of the special issue, “Advances in Therapeutics against Eukaryotic Pathogens” (https://lnkd.in/gFJt2WM4), by Mollineda-Diogo, N. and colleagues. #TherapeuticDrugDiscovery #Leishmaniasis #NTDs Link to the Article: https://lnkd.in/e7ZkRnBQ

A snippet from the last issue! 🙌 Better modifications for nucleotides: Modified nucleotides are increasingly used in biotech and therapeutics (the Covid vaccine anyone?). But making them is not easy: so, this study presents a new method for synthesizing chemically modified oligonucleotides using template-dependent DNA ligation with T3 DNA ligase. It offers improved scalability and flexibility, producing oligonucleotides of varying lengths (20–120 nucleotides) and tolerating diverse modifications. #synbio #molecularbiology #drugdelivery Read and subscribe at the link in bio!

At #Sannova, we understand the pivotal role that sensitivity and selectivity play in the successful development of #OligonucleotideTherapeutics. Accurate detection and quantification of #ASOs, siRNAs and miRNAs at low concentrations are essential for assessing efficacy and toxicity, particularly during PK and TK testing.  Our newest whitepaper delves deeper into this topic, highlighting the importance of bioanalytical and chemical manufacturing control in Oligonucleotide Therapeutic Development and #BioanalyticalExcellence. Download it now for expert insights to drive your research forward.

Dr. Gursharan Singh and his Ph.D. scholar, Ms. Anindita Sharma, have made a contribution to scientific literature with their review article titled "Antifungal Peptides: Therapeutic Potential and Challenges Before Their Commercial Success" Published in the prestigious International Journal of Biological Macromolecules (Impact Factor: 7.7, Q1 Category), this work highlights groundbreaking insights into antifungal therapeutics. #mls #ResearchExcellence #ScientificBreakthrough #AntifungalResearch #AcademicSuccess #ProudMoment #lpu #thinkbig

Antibody Glycan Quality Predicted from CHO Cell Culture Media Markers and Machine Learning N-glycosylaion can have a profound effect on the quality of mAb therapeutics. In biomanufacturing, one of the ways to influence N-glycosylation patterns is by altering the media used to grow mAb cell expression systems. Here, we explore the potential of machine learning (ML) to forecast the abundances of N-glycan types based on variables related to the growth media. https://lnkd.in/gD9W_wrx #aspenalert #biotech #bioprocess

Check out this excellent (short) review of covalent molecule discovery!