PreciGenome’s Post

Great tools to study immuneresponse!

Explore our human M1/M2 macrophage polarization in vitro assay. A well-defined in vitro model to test the effect of drug-candidates on the M1/M2 balance!

Don't miss your chance to attend Technical Session Vll on Friday, July 12, from 8:00-10:00am CET. This session provides a great opportunity for attendees to gain understanding of siRNA nanocarriers to reach undruggable oncoproteins such as KRAS, MSC-derived EVs (MSC-EVs) to treat liver fibrosis, exploiting the protein corona for plasma proteome profiling in diagnostics, advances in controlled transdermal delivery of antitubercular drugs, and the use of fucoidan, a natural polysaccharide, to engineer anti-tumor fucoidan-based nanoparticles. Speaker Highlight: Deborah Bitterfield, PdD Roberta Cavalli, PhD Dong Yun Lee, PhD Hélder A. Santos, DSc Yoon Yeo, PhD Full Schedule: https://ow.ly/9pFj50SrLO1 #CRS2024 #deliveryscience #pharma #drugdelivery #scientist #scienceandtechnology #researchandevelopment

Introducing our latest Advances in Bioanalysis Feature! Explore tailored solutions for cost-effective and timely bioanalysis, learn more about drug development optimization and bioanalysis trends, find out how context of use (COU) influences cell counting in cell therapy manufacturing, and discover how immunoassays drive bioanalysis advancements. #bioanalysis #drugdevelopment

How can we identify previously undiscovered druggable protein pockets to design novel small molecule drugs? Michael Crackower, Chief Scientific Officer at Ventus Therapeutics, and Jason Burch believe the secret lies with water. Ventus' ReSOLVE platform incorporates dynamic water modeling into molecular dynamics simulations empowering their expert drug hunters to find new targets and design better small molecule drugs. The approach has led to a rare accomplishment - 3 clinical trials initiated within one year. Recently, Mike and Jason joined Vineeta Agarwala, MD PhD, a16z general partner, to discuss how this technology works and its potential impact in our industry. Listen on Raising Health: https://lnkd.in/dR5t7fP2

Greetings Connections! Interesting to share my molecular docking experiences with you all! I am performing rigid docking for different oncoproteins with some of the FDA-approved chemotherapeutic drugs as my receptor and ligand. Here, I have performed molecular docking of the PALB2/BRCA2 complex with Abemaciclib drug and analyzed it on Discovery Studio and we can visualize the receptor-ligand interactions on a 2D diagram. I am overwhelmed to share my learnings with you all! Thanks & Regards. #bioinformatics #moleculardocking #oncoproteins #cancergenetics #computationalbiology

Check out this insightful editorial feature from SelectScience®, where Annika Carlsson, Director of Bioanalysis and Services at Mercodia, sheds light on how Mercodia's cost-effective bioanalytical solutions are shaping drug development success ✨ https://lnkd.in/gAuBr4zm #Bioanalysis #DrugDevelopement #Mercodia

Interesting feature from SelectScience® on advances in #Bioanalysis with expert insights into how bioanalytical breakthroughs redefine and optimize #DrugDevelopement.

Introducing our latest Advances in Bioanalysis Feature! Explore tailored solutions for cost-effective and timely bioanalysis, learn more about drug development optimization and bioanalysis trends, find out how context of use (COU) influences cell counting in cell therapy manufacturing, and discover how immunoassays drive bioanalysis advancements. #bioanalysis #drugdevelopment

“Synthesis and Preclinical Evaluation of PSMA-Targeted 111In-Radioconjugates Containing a Mitochondria-Tropic Triphenylphosphonium Carrier.” A new article was published in the scientific journal. “Molecular Pharmaceutics”   This article has as co-authors the researchers Joana F. Santos, Maria T. Braz, Paula Raposinho, Filipa Mendes, Célia Fernandes and António Paulo of C2TN - Centro de Ciências e Tecnologias Nucleares of Instituto Superior Técnico! For more information about this article, please check this link:   https://lnkd.in/gUwrsYd3   #disseminação #ciência #novoartigo #c2tn #dual-targeting #PSMA #mitochondria #radiopharmaceuticals #Augerelectronemitters #cancertheranostics