CIMB MDPI’s Post

Brittany Allen-Petersen's journey into cancer biology is deeply personal, rooted in the profound loss of her friend Sean Robins to Ewing sarcoma—a tragedy that ignited her unwavering commitment to understanding and combating this relentless disease. Ewing sarcoma is a type of tumor that forms from a certain kind of cell in bone or soft tissue. As an assistant professor of biological sciences at Purdue University's College of Science, Allen-Petersen's research delves into the intricate mechanisms underpinning cancer progression, with a focus on unraveling the mysteries of protein phosphatases. Read more about her research in the full article: bit.ly/3TBpyVa #Purdue #Science #Research #Biology #Cancer #CancerResearch #MyGiantLeap #TheNextGiantLeap

If prostate cancer is your area of expertise, check out this new study using Particle Metrix GmbH NTA technology to characterize #EVs. #ProstateCancer #Metastasis #CancerResearch #ExtracellularVesicles #Exosomes #NanoparticleTracking #NTA #ZetaView

Olfactory neuroblastoma (#ONB) mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer:- •The olfactory epithelium undergoes neuronal regeneration from basal stem cells and is susceptible to olfactory neuroblastoma (ONB), a rare tumor of unclear origins. •Employing alterations in Rb1/Trp53/Myc (RPM), we establish a genetically engineered mouse model of high-grade metastatic ONB exhibiting a NEUROD1+ immature neuronal phenotype. •We demonstrate that globose basal cells (GBCs) are a permissive cell of origin for ONB and that ONBs exhibit cell fate heterogeneity that mimics normal GBC developmental trajectories. •ASCL1 loss in RPM ONB leads to emergence of non-neuronal histopathologies, including a POU2F3+ microvillar-like state. •Similar to small-cell lung cancer (SCLC), mouse and human ONBs exhibit mutually exclusive NEUROD1 and POU2F3-like states, an immune-cold tumor microenvironment, intratumoral cell fate heterogeneity comprising neuronal and non-neuronal lineages, and cell fate plasticity—evidenced by barcode-based lineage tracing and single-cell transcriptomics. •Collectively, our findings highlight conserved similarities between ONB and neuroendocrine tumors with significant implications for ONB classification and treatment. #highlights :- •Rb1/Trp53/Myc alterations promote high-grade metastatic NEUROD1+ ONB. •Mouse and human ONBs exhibit transcriptional similarity to neuroendocrine tumors. •ONB harbors intratumoral cell fate heterogeneity and lineage plasticity. •ASCL1 suppresses non-neuronal lineages including POU2F3+ microvillar-like states.

‘Chromosomal chaos promotes therapy resistance in leukemia cells and opens up new treatment approaches’ – Scientists from the DKFZ German Cancer Research Center, HI-STEM gGmbH: The Heidelberg Institute for Stem Cell Technology and Experimental Medicine, and European Molecular Biology Laboratory (EMBL) discover genetic and non-genetic factors determine the functional heterogeneity of blood cancer cells and reveal new therapeutic targets: https://lnkd.in/gG2yE93x Paper: https://lnkd.in/gpuTxM_s #stemcell #stemcellscience #medicalresearch

"New research by a team of Indiana University School of Medicine scientists and their collaborators has uncovered a novel vulnerability in prostate cancer animal models that starves prostate tumors of critical nutrients and stunts their growth, which could lead to the development of new treatments for the deadly disease. Led by IU School of Medicine's Kirk Staschke, Ph.D., assistant research professor of biochemistry and molecular biology, and Ronald C. Wek, Ph.D., Showalter Professor of Biochemistry, the study was recently published in Science Signaling. Prostate cancer is a leading cause of cancer deaths in American men. Current treatments target the hormone testosterone, which prostate cancer cells need to grow. Unfortunately, prostate tumors frequently become resistant to these treatments, leaving doctors with few options to stop the disease." #prostatecancer #cancer #oncology

Scientists at VCU Massey Comprehensive Cancer Center have identified a new genetic code that recruits and deploys tumor cells to invade healthy organs and overpower normal cells. This discovery could unveil a new understanding of the origins of cancer within the body, as well as offer groundbreaking insight into new treatment strategies. VCU Health #VCUHealth #VCUMassey #MasseyMonday #MCVCampus Virginia Commonwealth University School of Medicine #VCUResearch

#CMHFLaureate Dr. Marco Marra and his team of researchers will be funded by The Terry Fox Research Institute and Marathon of Hope Cancer Centres Network for a new project aiming to improve early detection of hereditary cancers through advanced DNA sequencing.👏 https://ow.ly/rLiI50UcICW Faculty of Medicine at the University of British Columbia

Immune cells are a very important area of study for cancer researchers because understanding how they do (or do not) function against cancer is critical for developing therapies. Wistar’s Qing Chen, M.D., Ph.D., has confirmed that measuring the gene Tmem119 will allow her lab to better understand how microglia function in cases of brain metastasis. “This is an exciting confirmation that we can indeed identify and quantify activated microglia in cases of metastasis to the brain,” said Dr. Chen. “It’s a crucial first step in working to understand how these immune cells interact with cancer, and we look forward to future mechanistic studies of these cases.” Read our full story here: https://lnkd.in/eEtWxFpd #canccer #research #biomarker #metastasis #braincancer

Our study on disentangling complex amplicons in Esophageal adenocarcinoma is now online! We combined short reads, Oxford Nanopore Technologies long reads and scDNA-seq to understand the mechanisms behind these complex amplicons. Using both patient tumours and patient derived organoids, we find amplicon hotspots, assembled complex amplicons and tracked clonal shifts in clones with #ecDNA. It's only the start and we can use long reads + single cell technologies to understand how these amplicons play a role in cancer evolution! Rebecca Fitzgerald Karol Nowicki-Osuch Early Cancer Institute, University of Cambridge Cancer Research UK (CRUK) https://lnkd.in/dYeFKH8E https://lnkd.in/dhZfHP9u

Lung adenocarcinoma is the leading cause of cancer death worldwide. Two studies led by Carla Kim, PhD, in our Stem Cell Program offer insight into its early origins. Using single-cell RNAseq and mouse alveolar organoids, her team showed that mutations in the KRAS oncogene transform alveolar progenitor cells to a more plastic state. This change, needed for lung repair, is co-opted by the cancer. Now, Kim’s team is using human airway and alveolar organoids, made from bronchoalveolar lavage samples, to see if there are similar changes before lung tumors are detectable. 👉 http://ms.spr.ly/6048YiSK6