Pushpendra Singh’s Post

We have developed a new method which can be used to estimate the risk of sudden cardiac death! The recent study was published in JACC: Clinical Electrophysiology (https://lnkd.in/dZXvKnqy). The first symptom of an underlying heart disease is often a sudden cardiac death. However, if the risk factors are detected in time, the preventation of the lethal cardiac arrest is often possible. We can estimate the risk factor with any devices measuring heart rate and give a significantly better estimate of the risk than the conventional cardiorespiratory fitness tests! 🫀 🇬🇧 https://lnkd.in/dusnUR3n 🇫🇮 https://lnkd.in/dXj2auPV

👥 13,846 patients analyzed across 4 major heart failure trials: - #RALES (Spironolactone) - #EMPHASIS-HF (Eplerenone) - #TOPCAT (Spironolactone) - #FINEARTS-HF (Finerenone, our brand: Fineron) 📊 Key Findings: 🔹 MRAs reduced the risk of cardiovascular (CV) death or heart failure (HF) hospitalization by 23% (HR 0.77, 95% CI 0.72–0.83). 🔹 Greater efficacy in HFrEF: 34% reduction in CV death or HF hospitalization (HR 0.66). 🔹 Moderate benefit in HFmrEF/HFpEF: 13% reduction in risk (HR 0.87). 🔹 All-cause death reduced in HFrEF (HR 0.73), but not in HFmrEF/HFpEF. 📍 Steroidal MRAs reduce CV death or HF hospitalization in #HFrEF, while non-steroidal MRAs like #Fineron (Finerenone) show significant benefits for #HFmrEF and #HFpEF patients. 🏆 #HeartFailure #CardioRenal #Nephrology #CVOutcomes #Fineron https://t.co/M0bmQxnYC2

A groundbreaking study, co-led by experts at the University of Arizona College of Medicine – Tucson's Sarver Heart Center and published in Circulation, has unveiled a remarkable discovery: some artificial heart patients can regenerate heart muscle. Why is this significant? 1️⃣ It demonstrates the heart’s natural regenerative potential, challenging previous beliefs. 2️⃣ The findings pave the way for therapies that could stimulate muscle regeneration, potentially reducing reliance on transplants or mechanical devices. 3️⃣ This breakthrough offers hope for enhancing outcomes and quality of life for millions of heart failure patients worldwide. Discover more about this exciting development. #Cardiology #MedicalResearch #HeartHealth #Innovation

I found this article from Mayo Clinic very insightful. The research findings indicating a correlation between prolonged bed rest and cardiovascular and neuromuscular deconditioning are quite significant. Dr. Scarisbrick's summary explains how elevated levels of serum markers linked to neural injury and inflammation are associated with declines in neural reflex control. This, in turn, contributes to cardiovascular and postural deconditioning, especially in older adults. Understanding these mechanisms helps us better comprehend the effects of bed rest on both cardiovascular health and neurodegeneration, particularly in older adults. This new perspective opens up opportunities for developing improved exercise and biotherapeutic interventions. As physiotherapists, it underscores the importance of tailored rehabilitation programs aimed at cardiovascular function, maintaining neural reflex control, and preventing the adverse effects of bed rest on overall health and well-being. Did any healthcare professionals, encountered the effects of prolonged bed rest in your patients? Read the full article here: https://lnkd.in/gEriXMvB #Physiotherapy #CardiovascularHealth #NeuromuscularDeconditioning #BedRestEffects #MayoClinic #HealthResearch #insights

Exciting developments in heart failure research! 💡 A recent study published in Cardiovascular Research investigates sex-specific responses to heart failure treatment, shedding light on why therapies may differ for men and women with HFpEF. 🫀 Using mouse models, researchers uncover unique characteristics of HFpEF in males and females, offering valuable insights into potential treatment avenues. Complementing this, a multicenter observational study highlights sex-related differences in clinical outcomes among HFpEF patients. https://lnkd.in/ed7FHsGf #HeartFailure #HFpEF #GenderHealth #HealthcareInnovation #MedicalStudies #Publichealthsciences

"The accuracy of hippocampal volumetry and glucose metabolism for the diagnosis of patients with suspected Alzheimer's disease, using automatic quantitative clinical tools", editado para Medicine® em 2019: https://lnkd.in/d7w2t-_s #clínicaelysian #elysianclinic #elysianclínicamédicaneurologia

Alzheimer’s Brain Shrinkage Follows No Single Pattern A new study finds that brain shrinkage in Alzheimer’s patients does not follow a uniform pattern. Researchers examined thousands of brain scans and found that individuals showed varied shrinkage patterns over time. Those with faster shrinkage in specific brain regions were more likely to develop Alzheimer’s. This personalized approach to brain mapping may lead to tailored treatments based on individual brain changes. Key Facts: 1. Alzheimer’s patients show highly varied patterns of brain shrinkage. 2. Faster accumulation of outlier brain regions is linked to poorer memory. 3. Personalized brain maps could help predict disease progression and aid in treatment. Source: https://lnkd.in/g2iEWRa6

🧠 Another study highlights changes in cerebral blood flow (CBF) in patients with Alzheimer's disease as an early significant parameter in disease progression! 🔬 Study Design: A meta-analysis of data from MEDLINE and Scopus, focusing on investigations from January 2011 to November 2021. The studies compared cerebrovascular hemodynamics between Alzheimer’s disease patients and age-matched healthy controls using TCD. 💡 Key findings: 🕐 The significant decrease in CBF velocity in Alzheimer’s patients, implying potential utility in early diagnostic contexts (MD: -7.80 cm/s, 95%CI: -10.78 to -5.13, p < 0.0001, I² = 71.0%); 🕑 Increased pulsatility index points towards higher vascular resistance in Alzheimer's patients, which could be indicative of cerebrovascular aging or disease progression (MD: 0.16, 95%CI: 0.07 to 0.25, p < 0.0001, I²: 84.5%); 🕒 The reduced breath-holding index reflects decreased cerebrovascular reactivity, reinforcing the potential of TCD as a diagnostic tool to assess cerebral hemodynamics in Alzheimer's (MD: -1.72, 95%CI: -2.53 to -0.91, p < 0.001, I²: 85.4%). Check out here: https://lnkd.in/dYDgafrb #AlzheimersResearch #CerebralBloodFlow #TranscranialDoppler #Geriatrics

#Alzheimer #brainendothelialcell Thinking outside the black box: are the brain endothelial cells the new main target in Alzheimer’s disease? https://lnkd.in/gBMekb-2 The blood-brain barrier is the interface through which the brain interacts with the milieu and consists mainly of a sophisticated network of brain endothelial cells that forms blood vessels and selectively moves molecules inside and outside the brain through multiple mechanisms of transport.  Although brain endothelial cell function is crucial for brain homeostasis, their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia, astroglia, neurons, or even molecules such as amyloid beta, Tau, or alpha-synuclein.  Alzheimer’s disease is the most common neurodegenerative disease, and brain endothelial cell dysfunction has been reported by several groups.  However, its impairment has barely been considered as a potential therapeutic target.  Here we review the most recent advances in the relationship between Alzheimer’s disease and brain endothelial cells commitment and analyze the possible mechanisms through which their alterations contribute to this neurodegenerative disease, highlighting their inflammatory phenotype and the possibility of an impaired secretory pattern of brain endothelial cells that could contribute to the progression of this ailment.  Finally, we discuss why shall brain endothelial cells be appreciated as a therapeutic target instead of solely an obstacle for delivering treatments to the injured brain in Alzheimer’s disease.

📃Scientific paper: Aging-Associated Thyroid Dysfunction Contributes to Oxidative Stress and Worsened Functional Outcomes Following Traumatic Brain Injury Ref.: MDPI, 2023 Continued on ES/IODE ➡️ https://etcse.fr/tg3m ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. This post is part of our daily initiative to curate and share scientific studies, with full respect for copyright.