Custom Processing Services, Inc.’s Post

All-in-one milling platforms: How to reduce your machinery footprint   Often, many different machines are needed to complete a single pharmaceutical milling process. What if you could reduce that number, streamline operations and improve efficiency?  https://lnkd.in/eeJdcNME

𝗔𝗻 𝗲𝘅𝗽𝗲𝗿𝗶𝗺𝗲𝗻𝘁𝗮𝗹 𝘀𝘁𝘂𝗱𝘆 𝗼𝗻 𝗳𝗹𝗼𝘄 𝗯𝗲𝗵𝗮𝘃𝗶𝗼𝘂𝗿 𝗶𝗻 𝘀𝘂𝗰𝘁𝗶𝗼𝗻 𝗳𝗶𝗹𝗹𝗶𝗻𝗴 𝗼𝗳 𝗽𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹 𝗽𝗼𝘄𝗱𝗲𝗿𝘀 Die filling is a crucial step in the pharmaceutical tablet manufacturing process. For industrial-scale production using rotary presses, suction filling is typically employed due to its significant efficiency advantages over gravity filling. Despite its widespread use, our understanding of the suction filling process remains limited. Specifically, there is insufficient comprehension of how filling performance is influenced by factors such as suction velocity, filling velocity, and the properties of the powder materials. Building on our previous research, this study aims to further investigate the effects of powder properties and process parameters (e.g., filling velocity, suction velocity, fill depth) on suction filling behaviour.

In pharmaceutical analysis precision and efficiency are vital. discover the benefits solid phase microextraction (SPME) has to offer in form of low detection limits, automation and more. Expert Gyorgy Vas, owner of Vas Analytical, explains. This article is featured in our May 2024 publication, Pharmaceutical Purity and Precision. Explore the full issue here -- https://lnkd.in/gknDWte3 #SPME #pharma #sampleprep https://lnkd.in/eYxF3mM3

Discover how recent innovations in biopharmaceutical hose technology, from advanced materials to smart monitoring, enhance manufacturing efficiency, reduce downtime, and ensure product integrity. https://lnkd.in/gxJK7vgv #biopharma #pharmaceutical #lifescience #bioprocessing #Liquidyneusa #pharma #biotech #pharmaceuticalindustry #biotechnology #biomanufacturing #bioprocessing #pharmaindustry #pharmaceuticalmanufacturing #pharmanews #processengineer #processengineering #processengineers

Discover how recent innovations in biopharmaceutical hose technology, from advanced materials to smart monitoring, enhance manufacturing efficiency, reduce downtime, and ensure product integrity. https://lnkd.in/gxJK7vgv #biopharma #pharmaceutical #lifescience #bioprocessing #Liquidyneusa #pharma #biotech #pharmaceuticalindustry #biotechnology #biomanufacturing #bioprocessing #pharmaindustry #pharmaceuticalmanufacturing #pharmanews #processengineer #processengineering #processengineers

Enhancing Pharmaceutical Drying Efficiency: The Vacuum Tray Dryer Dryer for pharmaceutical operates on the principle of removing moisture from materials under reduced pressure, facilitating faster drying while preserving product integrity. Click here: https://lnkd.in/gapqbSMj #machining #cncmachining #instamachinist #machinist #manufacturing #cncmilling #engineering #machineshop #millingmachine #cncporn #cncmill 

Discover how recent innovations in biopharmaceutical hose technology, from advanced materials to smart monitoring, enhance manufacturing efficiency, reduce downtime, and ensure product integrity. https://lnkd.in/gxJK7vgv #biopharma #pharmaceutical #lifescience #bioprocessing #Liquidyneusa #pharma #biotech #pharmaceuticalindustry #biotechnology #biomanufacturing #bioprocessing #pharmaindustry #pharmaceuticalmanufacturing #pharmanews #processengineer #processengineering #processengineers

𝗢𝗽𝘁𝗶𝗺𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝘄𝗲𝘁 𝗴𝗿𝗮𝗻𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝗽𝗿𝗼𝗰𝗲𝘀𝘀 𝗳𝗼𝗿 𝗺𝗮𝗻𝘂𝗳𝗮𝗰𝘁𝘂𝗿𝗶𝗻𝗴 𝗥𝗶𝘃𝗮𝗿𝗼𝘅𝗯𝗮𝗻 𝗴𝗲𝗻𝗲𝗿𝗶𝗰 𝗶𝗺𝗺𝗲𝗱𝗶𝗮𝘁𝗲-𝗿𝗲𝗹𝗲𝗮𝘀𝗲 𝘁𝗮𝗯𝗹𝗲𝘁𝘀 𝘂𝘀𝗶𝗻𝗴 𝗣𝗕𝗣𝗞 𝗺𝗼𝗱𝗲𝗹𝗶𝗻𝗴 𝗮𝗻𝗱 𝘀𝗶𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻𝘀 Granulation is the critical process for the pharmaceutical development of poorly water-soluble drug products. Poorly formulated products have challenges in dissolution and bioequivalence studies. Rivaroxaban (RXB) is a poorly soluble drug and has 66% fasting bioavailability at a high strength of 20 mg. Learn more here: https://lnkd.in/eNKrsz9w #excipients

𝗔 𝘀𝘆𝘀𝘁𝗲𝗺𝗮𝘁𝗶𝗰 𝗰𝗼𝗺𝗽𝗮𝗿𝗶𝘀𝗼𝗻 𝗼𝗳 𝗳𝗼𝘂𝗿 𝗽𝗵𝗮𝗿𝗺𝗮𝗰𝗼𝗽𝗼𝗲𝗶𝗮𝗹 𝗺𝗲𝘁𝗵𝗼𝗱𝘀 𝗳𝗼𝗿 𝗺𝗲𝗮𝘀𝘂𝗿𝗶𝗻𝗴 𝗽𝗼𝘄𝗱𝗲𝗿 𝗳𝗹𝗼𝘄𝗮𝗯𝗶𝗹𝗶𝘁𝘆 Powder flow is one of the crucial factors affecting several pharmaceutical manufacturing processes. Problems due to insufficient powder flow reduce production process efficiency and cause suboptimum product quality. The U.S. Pharmacopoeia has specified four methods to evaluate the flowability of pharmaceutical powders, including angle of repose (AoR), compressibility index (CI) and Hausner ratio (HR), Flow through an orifice, and shear cell. Comparison within and between those methods with 21 powders (covering a wide range of flowability) was performed in this study. Strong correlation was observed between fixed base cone AoR, and fixed height cone AoR (R2 = 0.939). CI and HR values calculated from a tapped density tester (meeting USP standards), manual tapping, and Geopyc® correlated strongly (R2 > 0.9). AoR, CI/HR, minimum diameter for flowing through an orifice (dmin), and shear cell results generally correlate strongly for materials with flowability worse than Avicel® PH102. Both shear cell and CI/HR methods can reliably distinguish powders exhibiting poor flow. For materials with good flow, the ability to distinguish powders follows the order of AoR ≈ CI/HR > shear cell > dmin. The systematic comparison of the four common methods provides useful information to guide the selection of methods for future powder flow characterization. Given the limitations observed in all four methods, we recommend that multiple techniques should be used, when possible, to more holistically characterize the flowability of a wide range of powders. Read more here: https://lnkd.in/em-J4Fn7 #powderflow #excipients #pharmaceuticals IFF MEGGLE Excipients DFE Pharma

⏺ Complete Guide of " 𝐏𝐡𝐚𝐫𝐦𝐚𝐜𝐞𝐮𝐭𝐢𝐜𝐚𝐥 𝐏𝐫𝐨𝐜𝐞𝐬𝐬𝐢𝐧𝐠 𝐄𝐪𝐮𝐢𝐩𝐦𝐞𝐧𝐭: "- [ Get Glimpse Insights ] pharmaceutical processing equipment market segment is divided into oral, parenteral,#topical, and other modes of delivery. hashtag#Oralformulations is the most preferred mode of delivery, owing to its ease in consumption, convenience, safety, and cost-effectiveness ✅ 𝐂𝐥𝐢𝐜𝐤 𝐡𝐞𝐫𝐞 𝐟𝐨𝐫 𝐏𝐃𝐅 >> https://lnkd.in/dQ_TvnP8 #Pharmaceuticalprocessing includes a range of unit operations such as blending, milling, granulation, #tabletpressing, coating, and filling, depending on the mode of delivery. With the growing adoption of continuous manufacturing and the rising number of novel therapies in clinical development, #pharmaceuticalequipment is becoming a central inflection point for developing new therapies. 𝐌𝐨𝐝𝐞 𝐨𝐟 𝐃𝐞𝐥𝐢𝐯𝐞𝐫𝐲 ➮Oral Formulations ➮Parenteral formulations ➮Topical Formulation 𝐊𝐞𝐲 𝐂𝐨𝐦𝐩𝐚𝐧𝐢𝐞𝐬: GEA Group Sainty Syntegon Freund ACIC Pharmaceuticals Inc. Fette Compacting IDEX Corporation Kevin Process Technologies KORSCH AG MARCHESINI GROUP INDIA PRIVATE LIMITED #pharmaceuticalequipment #oral #parenteral #topical #healthcare #tabletpressing #coating #filling #SIP #CIP #ProcessSystems #Agitators #Homogenizers #ColloidMills #PharmaceuticalProcessingEquipmentMarket #PharmaceuticalProcessingEquipment #PharmaceuticalEquipment #PharmaceuticalPackagingEquipment #ProcessingEquipment