PharmaExcipients.com’s Post

An experimental study on flow behaviour in suction filling of pharmaceutical powders

All-in-one milling platforms: How to reduce your machinery footprint   Often, many different machines are needed to complete a single pharmaceutical milling process. What if you could reduce that number, streamline operations and improve efficiency?  https://lnkd.in/eeJdcNME

Jet Milling is a cutting-edge technology that has revolutionized the way pharmaceutical particle size reduction is achieved. In this post, we'll delve into five fundamental ways in which Jet Milling enhances the process, leading to more precise and effective results.🔬💊 #ParticleSize

𝗔 𝘀𝘆𝘀𝘁𝗲𝗺𝗮𝘁𝗶𝗰 𝗰𝗼𝗺𝗽𝗮𝗿𝗶𝘀𝗼𝗻 𝗼𝗳 𝗳𝗼𝘂𝗿 𝗽𝗵𝗮𝗿𝗺𝗮𝗰𝗼𝗽𝗼𝗲𝗶𝗮𝗹 𝗺𝗲𝘁𝗵𝗼𝗱𝘀 𝗳𝗼𝗿 𝗺𝗲𝗮𝘀𝘂𝗿𝗶𝗻𝗴 𝗽𝗼𝘄𝗱𝗲𝗿 𝗳𝗹𝗼𝘄𝗮𝗯𝗶𝗹𝗶𝘁𝘆 Powder flow is one of the crucial factors affecting several pharmaceutical manufacturing processes. Problems due to insufficient powder flow reduce production process efficiency and cause suboptimum product quality. The U.S. Pharmacopoeia has specified four methods to evaluate the flowability of pharmaceutical powders, including angle of repose (AoR), compressibility index (CI) and Hausner ratio (HR), Flow through an orifice, and shear cell. Comparison within and between those methods with 21 powders (covering a wide range of flowability) was performed in this study. Strong correlation was observed between fixed base cone AoR, and fixed height cone AoR (R2 = 0.939). CI and HR values calculated from a tapped density tester (meeting USP standards), manual tapping, and Geopyc® correlated strongly (R2 > 0.9). AoR, CI/HR, minimum diameter for flowing through an orifice (dmin), and shear cell results generally correlate strongly for materials with flowability worse than Avicel® PH102. Both shear cell and CI/HR methods can reliably distinguish powders exhibiting poor flow. For materials with good flow, the ability to distinguish powders follows the order of AoR ≈ CI/HR > shear cell > dmin. The systematic comparison of the four common methods provides useful information to guide the selection of methods for future powder flow characterization. Given the limitations observed in all four methods, we recommend that multiple techniques should be used, when possible, to more holistically characterize the flowability of a wide range of powders. Read more here: https://lnkd.in/em-J4Fn7 #powderflow #excipients #pharmaceuticals IFF MEGGLE Excipients DFE Pharma

𝗔𝗻𝗮𝗹𝘆𝘀𝗶𝘀 𝗼𝗳 𝗣𝗼𝘄𝗱𝗲𝗿 𝗣𝗿𝗼𝗽𝗲𝗿𝘁𝗶𝗲𝘀 𝗼𝗳 𝗣𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹 𝗘𝘅𝗰𝗶𝗽𝗶𝗲𝗻𝘁𝘀 𝗨𝘀𝗶𝗻𝗴 𝗮 𝗖𝗼𝗻𝘀𝘁𝗮𝗻𝘁-𝗩𝗼𝗹𝘂𝗺𝗲 𝗦𝗵𝗲𝗮𝗿 𝗧𝗲𝘀𝘁𝗲𝗿 Powders used in pharmaceuticals require good flowability. The angle of repose and compressibility index are often used to measure the flowability of pharmaceutical powders. However, confirming the relationship between external forces and flowability for smooth powder handling is necessary. Therefore, we measured pharmaceutical excipient powder using a lower cell direct movable constant-volume shear tester and evaluated the powder’s physical properties. In this study, we utilized microcrystalline cellulose, widely used as a pharmaceutical excipient and developed in many grades with different physical properties such as particle shape. We measured the shear parameters that describe the characteristic friction and cohesion properties of each microcrystalline cellulose grade. We found that the relative compression ratio (RCR) correlated with the angle of repose. Differences in the shape of the powder yield locus were observed among the grades, and the ratio of the upward convex area of the powder yield locus curve (APC) was defined as the value that quantified these differences. The study used various grades of #Ceolus #microcrystallinecellulose by Asahi Kasei

Discover the cutting-edge advantages of combining lipids and polymers in extrusion processes! Learn more about how these advancements are shaping pharmaceutical manufacturing by checking out the #PBPWorldMeeting poster from Gattefossé Pharmaceuticals and Thermo Fisher Scientific. #pharmaceutical #excipients #innovation #extrusion

𝗖𝗼𝗺𝗽𝗿𝗲𝗵𝗲𝗻𝘀𝗶𝘃𝗲 𝗥𝗲𝘃𝗶𝗲𝘄 𝗼𝗳 𝗠𝗼𝗱𝗲𝗿𝗻 𝗧𝗲𝗰𝗵𝗻𝗶𝗾𝘂𝗲𝘀 𝗼𝗳 𝗚𝗿𝗮𝗻𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝗶𝗻 𝗣𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹 𝗦𝗼𝗹𝗶𝗱 𝗗𝗼𝘀𝗮𝗴𝗲 𝗙𝗼𝗿𝗺𝘀 This comprehensive review explores modern granulation techniques in pharmaceutical dosage forms along with conventional methods, focusing on dry granulation and wet granulation. Dry granulation techniques, including slugging, roller compaction, and pneumatic dry granulation, are dissected with thorough analyses of their processing methods, advantages, disadvantages, and diverse applications. The article delves into eleven wet granulation techniques, offering insights into high-shear granulation, low-shear granulation, fluidized bed granulation, reverse wet granulation, steam granulation, moisture-activated dry granulation, melt granulation, freeze-dry granulation, foam granulation, thermal adhesion, and twin screw wet granulation. Each method is scrutinized, providing a comprehensive understanding of its processing steps, merits, drawbacks, and practical applications in pharmaceutical manufacturing. #pharmaceutical #granulation

Imagine being able to simplify your pharmaceutical milling process by reducing the number of machines needed. With Frewitt innovative solutions, you can streamline operations and improve efficiency like never before. #pharmaceuticalindustry #innovation #efficiency #milling #api #druminverter #savingcosts #sizereductionexperts #pinmill #swissmade

𝗧𝗵𝗲 𝗲𝗳𝗳𝗲𝗰𝘁 𝗼𝗳 𝗴𝗹𝗶𝗱𝗮𝗻𝘁 𝗼𝗻 𝘁𝗵𝗲 𝘁𝗮𝗯𝗹𝗲𝘁𝘁𝗶𝗻𝗴 𝗯𝗲𝗵𝗮𝘃𝗶𝗼𝗿 𝗼𝗳 𝗰𝗼𝗺𝗺𝗼𝗻 𝗽𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹 𝗲𝘅𝗰𝗶𝗽𝗶𝗲𝗻𝘁𝘀 Glidant used for the purpose of powder flowability enhancement is well known within the pharmaceutical industry to improve tablet manufacturing. Despite the widespread use of glidant for this purpose, the effect of glidant on the effect of tableting behavior is not well studied. To address this deficiency, the effect on glidant on the tabletting behavior of seven common excipients was investigated. Tabletability, compressibility, compactability, and tablet expansion were studied. It was shown that glidant increased the tabletability for excipients known to exhibit plastic behavior. Based on compressibility and compactability, it was inferred that an increase in total bonding strength due to the presence of glidant was responsible for the improvement in tabletability. Results suggest this may be due to an increase in inter-particle bonding area. Conversely, glidants did not affect the tabletability of brittle excipients. Read more in the article. #pharmaceutical #excipients #glidants

𝗔𝗻𝗮𝗹𝘆𝘀𝗶𝘀 𝗼𝗳 𝗣𝗼𝘄𝗱𝗲𝗿 𝗣𝗿𝗼𝗽𝗲𝗿𝘁𝗶𝗲𝘀 𝗼𝗳 𝗣𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹 𝗘𝘅𝗰𝗶𝗽𝗶𝗲𝗻𝘁𝘀 𝗨𝘀𝗶𝗻𝗴 𝗮 𝗖𝗼𝗻𝘀𝘁𝗮𝗻𝘁-𝗩𝗼𝗹𝘂𝗺𝗲 𝗦𝗵𝗲𝗮𝗿 𝗧𝗲𝘀𝘁𝗲𝗿 Powders used in pharmaceuticals require good flowability. The angle of repose and compressibility index are often used to measure the flowability of pharmaceutical powders. However, confirming the relationship between external forces and flowability for smooth powder handling is necessary. Therefore, we measured pharmaceutical excipient powder using a lower cell direct movable constant-volume shear tester and evaluated the powder’s physical properties. In this study, we utilized microcrystalline cellulose, widely used as a pharmaceutical excipient and developed in many grades with different physical properties such as particle shape. We measured the shear parameters that describe the characteristic friction and cohesion properties of each microcrystalline cellulose grade. We found that the relative compression ratio (RCR) correlated with the angle of repose. Differences in the shape of the powder yield locus were observed among the grades, and the ratio of the upward convex area of the powder yield locus curve (APC) was defined as the value that quantified these differences. Learn more here: https://lnkd.in/eGD4jbZ8 The study used various grades of #Ceolus #microcrystallinecellulose by Asahi Kasei