CVPath Institute, Inc.’s Post

SARCOPENIA . "The data collected in this review highlight that the two central biological processes—efferocytosis by macrophages and myogenesis—that contribute to the successful muscle repair share quite a number of PS‐dependent receptors and signalling pathways. We propose that the involvement of PS receptors in both the myoblast‐related and the macrophage‐related muscle regeneration processes makes them an excellent target in promoting muscle repair following acute muscle injury, because stimulating the function of them would facilitate efferocytosis by macrophages and myogenesis simultaneously." https://lnkd.in/eQ-AnwKu

Examining extracellular vesicle-mediated mechanisms of tumour progression: in this review article, Pragati Lodha, Lothar Dieterich at Heidelberg University and collaborators emphasised the critical role of the lymphatic vascular system in distributing tumour cell-derived EVs and promoting tumour progression. They noted that as the primary drainage network for interstitial fluid, along with its soluble, particulate, and cellular contents, the lymphatic system serves as a key pathway for both regional transport, such as to tumour-draining lymph nodes, and systemic dissemination of EVs from solid tumours https://lnkd.in/gHmvVM52 They also highlighted that emerging research underscores the tumour-draining lymph node as a pivotal site where tumour-derived EVs exert significant biological effects. An article co-authored by Alperen Acari, Jochen Rieck and Sarah Hofmann #extracellularvesicles #exosomes #lymphnode #tumourimmunity #Vesiculab

In neonates with mild hypoxicischemic encephalopathy, whole-body hypothermia did not improve cerebral magnetic resonance biomarkers, although neonates in the hypothermia groups were sicker at baseline, finds pilot RCT. https://ja.ma/3wnWmcs

Mitochondrial Fission Factor (MFF) is an important mitochondrial membrane protein that is required for normal functioning of cell organelles. It works by binding the GTPase dynamin-related protein 1 (DRP1) to mitochondria. Mutations in MFF result in failure to recruit DRP1 into the mitochondria leading to encephalopathy. Patients present with developmental delay, regression of acquired development, microcephaly, severe hypotonia, peripheral neuropathy, optic atrophy, and early-onset seizures. Learn more about the testing with Medical Database. https://lnkd.in/dex7MU5z #medicaldatabase

Fascinating study from @Tulane sheds light on how sex-specific epigenetic changes affect hypertension and kidney function. Histone modifications & MGCD treatment highlighted key insights in GC-A/NPRA-modified mice. Learn more: https://lnkd.in/ekbxwsRw Featured EpigenTek Kits: EpiQuik Total Histone Extraction Kit: https://lnkd.in/eAy3xWwv EpiQuik HAT Activity/Inhibition Assay Kit: https://lnkd.in/eURc4vMw Epigenase HDAC Activity/Inhibition Direct Assay Kit (Colorimetric): https://lnkd.in/eeRDDcp3

Loss of proteostasis and cellular senescence have been previously established as characteristics of aging, however their interaction in the context of lung aging and potential contributions to aging-associated lung remodeling remains understudied. The study below suggests that ER stress response plays an important role in establishment and maintenance of a senescence phenotype in lung fibroblasts and therefore contributes to altered remodeling in the aging lung. https://lnkd.in/gmDRs_Cz

In conclusion, we revealed that telomeres of endothelial cells implicated in coronary atherosclerosis were markedly shortened. This finding suggests that telomere shortening and replicative cellular senescence in coronary endothelial cells are focal phenomena and may play pathogenic roles in coronary atherogenesis and CAD. https://lnkd.in/g3c_JyY7

In conclusion, we revealed that telomeres of endothelial cells implicated in coronary atherosclerosis were markedly shortened. This finding suggests that telomere shortening and replicative cellular senescence in coronary endothelial cells are focal phenomena and may play pathogenic roles in coronary atherogenesis and CAD. https://lnkd.in/gefif7QE

Heart cardiolipin --- Cardiolipin is a crucial phospholipid in heart mitochondria, essential for maintaining normal mitochondrial structure and function in heart cells. Cardiac cardiolipin production involves its biosynthesis and remodeling. Scientists explored how cardiolipin biosynthesis and the enzyme cardiolipin synthase (CLS) affect heart function. In mice, CLS and cardiac cardiolipin levels dropped significantly in heart cells after catecholamine-induced heart damage, leading to increased oxygen consumption, oxidative stress, and mitochondrial uncoupling. Knocking down CLS specifically in the heart cells of Drosophila melanogaster caused significant heart dilatation, poor systolic function, and other heart function impairment. Read the full publication here: https://lnkd.in/eMvnChe6 #research #lipid #lipidomics #LipidMetabolism #lipotype #lipidome #MassSpectrometry #cardiolipin