Danaher Life Sciences’ Post

Developing and screening plasmid libraries is critical to biotherapeutic development. Maintaining plasmid libraries and preventing evolution is essential for consistent manufacturing. Learn how Danaher Life Sciences can help: https://bit.ly/4d3eHw8 #DanaherLifeSciences #pDNA #plasmid #drugdiscovery #drugdevelopment

2D-LC is an excellent tool for DAR determination and analysis.

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Lipid nanoparticles (LNPs) have gained so much attention due to the launch of vaccines and therapeutics in the past few years. Comprised typically of four lipid components, not all #LNPs are encapsulated with nucleic acids cargo, though the ratios of encapsulated/unencapsulated LNPs remain high. Ascendia Pharma’s expertise and #cGMP capabilities, along with maintaining a library of novel ionizable lipids, can help formulate the nucleic acids and plasmids in LNPs by employing our state-of-the-art NanoAssemblr® microfluid systems from Cytiva. Our team uses Ignite, Blaze and GMP equipment to manufacture preclinical and clinical batches for Phase 1 trials and later phases. Learn more: https://bit.ly/3WycDWD #lipidnanoparticles #drugdevelopment

𝗠𝗶𝗰𝗿𝗼𝗻𝗲𝗲𝗱𝗹𝗲 𝗽𝗮𝘁𝗰𝗵 𝗰𝗮𝘀𝘁𝗶𝗻𝗴 𝘂𝘀𝗶𝗻𝗴 𝗮 𝗺𝗶𝗰𝗿𝗼𝗺𝗮𝗰𝗵𝗶𝗻𝗲𝗱 𝗰𝗮𝗿𝗯𝗼𝗻 𝗺𝗮𝘀𝘁𝗲𝗿 𝗳𝗼𝗿 𝗲𝗻𝗵𝗮𝗻𝗰𝗲𝗱 𝗱𝗿𝘂𝗴 𝗱𝗲𝗹𝗶𝘃𝗲𝗿𝘆 For successful treatment of diseases, sufficient therapeutics must be provided to the body. Microneedle applications in therapeutic delivery and analytics sampling are restricted because of various issues, including smaller area for drug loading and analytics sampling. To achieve sufficient drug loading and analytics sampling and improve drug penetration while maintaining painless administration, patch-type microneedle arrays were designed and fabricated using polymer casting from a conical cavity mold. Learn more here: https://lnkd.in/et7bX9M3

This post highlights Ascendia Pharmaceuticals' expertise in formulating nucleic acids and plasmids in lipid nanoparticles (LNPs) using advanced microfluid systems. It emphasizes the company's cGMP capabilities and innovative approach in drug development. • Lipid nanoparticles have become crucial in vaccine and therapeutic development, showcasing the importance of innovative drug delivery systems. • Manufacture of LNPs for preclinical and clinical phases is facilitated by Ascendia's use of NanoAssemblr microfluid systems, ensuring high-quality production. • Innovation in drug development is underscored by Ascendia's library of novel ionizable lipids, enhancing the formulation process for LNPs. 💡You may want to consider exploring partnerships or collaborations that leverage Ascendia's advanced LNP formulation capabilities for your pharmaceutical projects.

Thinking on linkers for #antibodydrugconjugates 👇 C&EN discuss how a linker may be a small part of an antibody-drug conjugate, but drugmakers are finding that linker chemistry is important. Read the article below 👇 https://lnkd.in/dXNpwqbq

Thoughts on this? >> Acrivon draws in $130M; Vincerx Pharma's Ph1 metastatic tumor data >> Comment below! >>> lqventures.com #strategy #competitiveintelligence #marketing #biotech #pharma #productmarketing #pharmaceutical #healthcare

Trying to find the right receptor ligand binding assay for your lead optimization? Download our handy guide to explore the range of receptor ligand binding assays that Gifford Bioscience offer. Our interactive table covers the outcome for each technique, its suitability for your sample type and the pros and cons. If you need more help selecting the right assay, our expert scientists can offer their advice and guidance on our range of complex and niche assays. Speak directly to one of our PhD scientists from day one and partner with the specialists in receptor ligand binding assays. For interactive mode, expand to full screen and click on "Accessibility Mode", top right. #receptorpharmacology #drugdiscovery #pharmacology

Towards better drugs: increase affinity with low energy conformations.