Dermagnostix’s Post

📜 The DocTIS team at the University of Verona has published an article in the American Journal of Clinical Dermatology (by Springer Nature Group) exploring the link between psoriasis and metabolic comorbidities, including obesity, hypertension, diabetes, dyslipidemia, and non-alcoholic fatty liver disease.   💉 Psoriasis is one of the six immune-mediated inflammatory diseases (IMIDs) addressed by the European DocTIS project, which aims to leverage the specificity and efficacy of modern targeted therapies.     ⏩ For more information, visit: https://lnkd.in/dwK2CPk2     #DocTISProject #IMIDs #IMID #Psoriasis #Dermatology

📢 Meet us at the 16th ESCD --- We are excited to announce our participation in the 16th Congress of the European Society of Contact Dermatitis (ESCD), from September 4-7, 2024, in Dresden. Skin lipids are pivotal in the pathogenesis of contact dermatitis, playing a key role in maintaining the skin barrier and modulating immune responses. Therapeutic strategies that restore or mimic the skin’s natural lipid composition can enhance barrier function and alleviate symptoms of contact dermatitis. Understanding the role and metabolism of skin lipids is crucial for developing effective treatments for allergic and inflammatory skin diseases. We look forward to discovering the latest updates in basic and translational research, while also networking with leading experts in the field. 🔗Schedule a meeting with Lipotype: https://lnkd.in/edcMS_9g Dr. Veronika Piskovatska Marta Vicini Jeongeun Chae #ESCD2024 #ContactDermatitis #SkinHealth #Dermatology #SkinLipids #Research #Networking #Innovation #lipid #lipotype #lipidomics

🌟 Rare Disease Spotlight: Pemphigus 🌟 A disease that causes blistering of the skin and the inside of the mouth, nose, throat, eyes, and genitals. Pemphigus is an autoimmune disease in which the immune system mistakenly attacks cells in the top layer of the skin (epidermis) and the mucous membranes. 📌 People with the disease produce antibodies against desmogleins, proteins that bind skin cells to one another. When these bonds are disrupted, skin becomes fragile, and fluid can collect between its layers, forming blisters. ⚡ There are several types of pemphigus, but the two main ones are: 🔶 Pemphigus vulgaris, which normally affects the skin and mucous membranes such as the inside of the mouth. 🔶 Pemphigus foliaceus, which only affects the skin. 📌 There is no cure for pemphigus, but in many cases, it is controllable with medications. #Dermatology #AutoimmuneDiseases #Pemphigus #MedicalResearch

𝑾𝒉𝒂𝒕 𝒐𝒑𝒑𝒐𝒓𝒕𝒖𝒏𝒊𝒕𝒊𝒆𝒔 𝒅𝒐 𝑽𝑯𝑯 𝒔𝒅𝑨𝒃𝒔 (𝒔𝒊𝒏𝒈𝒍𝒆-𝒅𝒐𝒎𝒂𝒊𝒏 𝒂𝒏𝒕𝒊𝒃𝒐𝒅𝒊𝒆𝒔) 𝒑𝒓𝒆𝒔𝒆𝒏𝒕 𝒇𝒐𝒓 𝒕𝒓𝒆𝒂𝒕𝒊𝒏𝒈 𝒎𝒊𝒍𝒅 𝒕𝒐 𝒎𝒐𝒅𝒆𝒓𝒂𝒕𝒆 𝒑𝒍𝒂𝒒𝒖𝒆 𝒑𝒔𝒐𝒓𝒊𝒂𝒔𝒊𝒔? 𝑯𝒐𝒘 𝒅𝒐𝒆𝒔 𝑺𝒄𝒊𝒏𝒂𝒊 𝑰𝒎𝒎𝒖𝒏𝒐𝒕𝒉𝒆𝒓𝒂𝒑𝒆𝒖𝒕𝒊𝒄𝒔 𝑳𝒕𝒅.'𝒔 𝒊𝒏𝒕𝒓𝒂𝒍𝒆𝒔𝒊𝒐𝒏𝒂𝒍 𝑨𝒏𝒕𝒊-𝑰𝑳17 𝑨/𝑭 𝒔𝒅𝑨𝑩 𝒘𝒐𝒓𝒌, 𝒂𝒏𝒅 𝒘𝒉𝒚 𝒊𝒔 𝒊𝒕 𝒖𝒏𝒊𝒒𝒖𝒆𝒍𝒚 𝒑𝒐𝒔𝒊𝒕𝒊𝒐𝒏𝒆𝒅 𝒕𝒐 𝒎𝒆𝒆𝒕 𝒕𝒉𝒆 𝒔𝒊𝒈𝒏𝒊𝒇𝒊𝒄𝒂𝒏𝒕 𝒖𝒏𝒎𝒆𝒕 𝒏𝒆𝒆𝒅𝒔 𝒊𝒏 𝒕𝒉𝒊𝒔 𝒎𝒂𝒓𝒌𝒆𝒕? Hear our distinguished expert panel address these questions, during the panel discussion: "𝐏𝐥𝐚𝐪𝐮𝐞 𝐏𝐬𝐨𝐫𝐢𝐚𝐬𝐢𝐬. 𝐓𝐡𝐞 𝐔𝐧𝐦𝐞𝐭 𝐍𝐞𝐞𝐝 𝐚𝐧𝐝 𝐈𝐧𝐭𝐫𝐚𝐥𝐞𝐬𝐢𝐨𝐧𝐚𝐥 𝐈𝐧𝐣𝐞𝐜𝐭𝐢𝐨𝐧𝐬 𝐨𝐟 𝐀𝐧𝐭𝐢-𝐈𝐋𝟏𝟕 𝐀/𝐅 𝐕𝐇𝐇 𝐚𝐧𝐭𝐢𝐛𝐨𝐝𝐢𝐞𝐬 𝐚𝐬 𝐚 𝐩𝐨𝐭𝐞𝐧𝐭𝐢𝐚𝐥 𝐬𝐨𝐥𝐮𝐭𝐢𝐨𝐧". -Prof. Michael Schön – Director, Department of Dermatology and Venereology, University Medical Center Goettingen -Prof. Matthias Dobbelstein – Max Planck Institute Fellow, Professor and Department Head, University Medical Center Göttingen (UMG) - Amir Reichman – CEO, Scinai Immunotherapeutics Ltd. - Dr. Tamar Ben-Yedidia – CSO, Scinai Immunotherapeutics Ltd. View the full webinar recording to discover insights into the plaque psoriasis landscape, the current treatment options, the unmet need; and the potential of VHH sdAbs to transform psoriasis care. https://lnkd.in/dW8BH3KE #PsoriasisTreatment #VHHsdAbs #Immunotherapy #Biotechnology #Dermatology #ScinaiImmunotherapeutics #InnovativeHealthcare

Imagine integrating genetic testing and a comprehensive drug efficacy panel into your treatment plans. 🧬 Imagine detailed reports with recommended compounds based on efficacy levels. 💊 Imagine the transformative impact on your treatment outcomes. 🚀 Join our webinar to learn about this revolutionary approach through clinical cases. 🌟 #genetictesting #personalizedmedicine

Check out the NACE Webcast: Atopic Dermatitis: Evaluation and Targeted Management. Atopic dermatitis (AD) is a chronic relapsing and remitting inflammatory skin disease that commonly presents in childhood. It is characterized primarily by scaly, pruritic, erythematous lesions located on flexural surfaces. The itch that accompanies AD has a significant impact on patients’ quality of life, with the most prominent impact being on sleep quality. Fortunately, a new understanding of its underlying pathophysiology has brought about a variety of effective treatment options for patients suffering from AD, from topical agents to biologics and oral Janus kinase (JAK) inhibitors. In this webcast, Mona Shahriari, MD, FAAD, will share her valuable insights on differential diagnosis, treatment goals, and individualizing treatment plans. Click here to start the course: https://bit.ly/3WdObsm #NACE #Dermatology #Webcast

Psoriasis is a chronic inflammatory skin condition characterized by excessive keratinocyte growth and immune cell infiltration. Although the exact causes are still not fully understood, recent research suggests that iron imbalance may contribute to the disease. Remarkably, research dating back as far as fifty years has shown elevated iron levels in the epidermis of patients with psoriasis.  In a recent study published in Nature Communications by Nature Portfolio, scientists focused on hepcidin, a hormone that regulates iron levels in the body. Using in vitro 3D skin cultures and in vivo mouse models, the research team established a key role for hepcidin in initiating skin inflammation in psoriasis. As hepcidin regulates iron levels and inflammation, modulating its activity may help manage chronic inflammation in patients with psoriasis. Psoriasis remains difficult to treat, and this study opens new avenues for exploring hepcidin as an actionable target for psoriasis management. We are proud that our product could assist in this discovery and contribute to advancing potential treatments for psoriasis. Abboud, E., Chrayteh, D., Boussetta, N. et al. Skin hepcidin initiates psoriasiform skin inflammation via Fe-driven hyperproliferation and neutrophil recruitment. Nat Commun 15, 6718 (2024). https://lnkd.in/gGzENa_S Elise Abboud, PhD #cellculture #skinresearch #dermatology

Today, thanks to advances in #medicalscience, we know that prurigo nodularis (PN) involves a complex interplay between the immune and nervous systems, leading to severe and pathological itching. In an exciting #dermatology development, the @FDA has just approved the breakthrough treatment Nemluvio® (nemolizumab-ilto), which targets Interleukin (IL)-31, a key neuroimmune cytokine involved in the severe itching, inflammation, and fibrosis seen in PN. Nemolizumab, a humanized IgG2 monoclonal antibody, works by inhibiting IL-31 signaling. Its approval is backed by data from two successful Phase 3 #clinicaltrials: OLYMPIA 1 and OLYMPIA 2, involving 560 patients. Results showed a significant reduction in itch intensity and #skin clearance for many patients, marking a huge step forward in managing this challenging condition. Key Efficacy Results: OLYMPIA 1: 22% of patients on nemolizumab saw at least a 4-point reduction in itch intensity, compared to just 2% in the placebo group. OLYMPIA 2: 25% of patients on nemolizumab experienced similar improvements versus 4% on placebo. Advancements like these highlight the importance of continued #dermatologyresearch in the connection between the immune system and chronic conditions. This is an exciting development for #healthcare providers and patients alike, offering new hope for managing prurigo nodularis. #Dermatology #FrontierDermatology #FDAApproval #Nemluvio #Nemolizumab #PrurigoNodularis #Dermatology #HealthcareInnovation #SkinCondition #HealthySkin #SkinHealth #BetterSkin #SkinGlow #GlowingSkin #SkinGoals https://lnkd.in/gtv_QWrM

👉This photo shows a patient with a basalioma (basal cell skin cancer) on the facial skin. Basalioma can grow for years and no pain is felt. 📌Although basaloma is mainly localized on the scalp, i.e. it is accessible for observation and self-monitoring, patients rarely seek timely medical attention. As a rule, they lubricate the appeared formation with some steroid ointments or “folk” remedies. Such treatment of course does not help and when the tumor turns into a non-healing ulcer and reaches a large size - only then they turn to specialists. 🧬The patient in the photo did not seek qualified medical help for a long time. After clinical examination and dermatoscopy, a clinical diagnosis of basalioma was made. 🍀Now, after removal of the tumor, the material will be sent for histological examination to confirm the diagnosis. #longevity #healthyaging #tissuerepair #skinaging #aging #skindiseases #biohacking #treatmentofskindiseases #drandreynovikov  #andreynovikov #dermatology #doctornovikov #novikovclinic #amdclinic #dermatologist #dermatooncologist #regenerativemedicine  #aestheticmedicine #cosmetology #cosmetologist #skincancer #dermatoscopy #dermoscopy #benignskintumors #nevus #moles  #moleremoval #cancerprevention #basalcellcarcinoma #skincheck #skincancerawareness #keratoma 

🎉 A Breakthrough in Treating Deadly Skin Disease: World-First Cure Achieved! In an incredible leap forward for medical science, researchers have successfully cured patients suffering from Toxic Epidermal Necrolysis (TEN), a rare and often fatal skin condition, through an innovative use of existing drugs. Published in Nature, this landmark study could pave the way for an approved curative therapy, offering hope where there was previously very little. 🔬 Study Highlights: ◾ TEN, characterized by severe skin blistering and a high mortality rate, was halted using JAK inhibitors, drugs already used for inflammatory diseases. ◾ The study not only saved lives but also opened new doors in the treatment of other severe skin disorders and inflammatory conditions. 🌍 Global Impact: This pioneering work represents a monumental step in dermatology and emergency medicine, showcasing the power of collaborative research and the repurposing of drugs to fast-track life-saving treatments. 🔗 https://lnkd.in/grttG9-Q #MedicalResearch #Dermatology #HealthcareInnovation #SkinDisease #LifeSavingResearch