PromoCell’s Post

Learn how NO benefit your skin. Besides light therapy with different wavelengths, there’re an emerging beauty tech called CAPT (Cold Atmospheric Plasma Therapy) that generates NO way more than light. We’re on a research migrating the CAP into home-use devices, thanks for DM if there’re any interests. #beautytech #beauty #redlighttherapy #plasma

Under the motto “Uncovering the Broad Spectrum of Psoriatic Disease” the 7th World Psoriasis & Psoriatic Arthritis Conference took place last week in Stockholm. The focus of the conference is to improve the lives of patients living with psoriatic disease by sharing significant achievements in the prevention, diagnosis, and treatment. With PsorX-LabDisk, we support dermatopathologists in the differential diagnosis of psoriasis and eczema - as there are still up to 50% misdiagnoses of the two skin diseases due to overlapping clinical and histological appearances. However, the feedback from the dermatologists at the conference was clear: ❗This is not enough❗The test needs to be introduced into dermatologists' practices for use at the point of care. How good that work on it is already in full swing in the Dermagnostix R&D team!💪🚀 This feedback once again reinforces our belief in the urgent need for molecular diagnostics for inflammatory skin diseases - both for dermatologists and pathologists. 💡You want to be part of the #DermagnosticFuture? Schedule a meeting with us now to learn more about PsorX: https://lnkd.in/egn75BGc #MolecularDiagnostics #Psoriasis #PsorX #Dermatology #Innovation #IFPA

📢 Meet us at the 16th ESCD --- We are excited to announce our participation in the 16th Congress of the European Society of Contact Dermatitis (ESCD), from September 4-7, 2024, in Dresden. Skin lipids are pivotal in the pathogenesis of contact dermatitis, playing a key role in maintaining the skin barrier and modulating immune responses. Therapeutic strategies that restore or mimic the skin’s natural lipid composition can enhance barrier function and alleviate symptoms of contact dermatitis. Understanding the role and metabolism of skin lipids is crucial for developing effective treatments for allergic and inflammatory skin diseases. We look forward to discovering the latest updates in basic and translational research, while also networking with leading experts in the field. 🔗Schedule a meeting with Lipotype: https://lnkd.in/edcMS_9g Dr. Veronika Piskovatska Marta Vicini Jeongeun Chae #ESCD2024 #ContactDermatitis #SkinHealth #Dermatology #SkinLipids #Research #Networking #Innovation #lipid #lipotype #lipidomics

🌟 Curious about topical corticophobia in patients? 🌟 By Adela Markota Cagalj, Josko Maric, Dubravka Vukovic, Zdenka Šitum Čeprnja, Tina Gogić Salapić, Ivan Buljan, and Shelly Melissa Pranić from University of Split In a groundbreaking study, researchers translated the TOPICOP scale into Croatian, aiming to create a platform for assessing this condition. Conducted at the University Hospital Centre Split's Dermatovenerology Department, the study involved 120 participants aged 12 to 68, including patients with atopic dermatitis (AD) and allergic contact dermatitis (ACD). The TOPICOP questionnaire features 12 insightful items that evaluate worries, beliefs, and behaviors related to topical corticophobia. Respondents shared their perceptions in just 10 minutes using a four-point Likert scale, achieving an impressive response rate of 94%! 🔍 Key Findings: - A reliable common factor emerged (Cronbach α = 0.85), indicating strong consistency. - No significant score differences were found between male and female participants or among various groups. This research not only enhances the measurement tools for topical corticophobia but also paves the way for better recognition and prevention strategies in dermatological care. Want to dive deeper into their findings? Check out the full video! https://lnkd.in/gtq2fHwN 🎥✨ This video is adapted from https://lnkd.in/gFYce7Je Medicina MDPI #Dermatology #HealthResearch #TopicalCorticophobia #PatientCare #ChronicConditions

Porokeratosis is a keratinization disorder with unclear etiopathogenesis, varied clinical presentation and characteristic histopathology, and is usually unresponsive to current therapeutic options. Until now, it was considered to be a clonal disorder with immunity, ultra violet radiation and other factors playing important roles in etiopathogenesis. It is now known that abnormalities in the mevalonate pathway are responsible for this clonal keratinization abnormality. New variants of porokeratosis like eruptive bullous, pruriginous, lichen planus like, follicular variants and porokeratoma have been described. While the cornoid lamella is the classical histopathologic feature, dermoscopy and reflectance confocal microscopy make the diagnosis clearer. Development of malignancy in a few variants is a concern. Linear, disseminated superficial actinic and giant lesions are most prone to developing malignancies. Bowen’s disease, squamous cell carcinoma, basal cell carcinoma and even melanoma have been reported in cases of long-standing porokeratosis. Newer modalities of therapy such as photodynamic therapy, ingenol mebutate and HMGCoA inhibitors may play a role in the future. Porokeratosis is mainly classified into localized and generalized forms. Common localized variants are classical porokeratosis of Mibelli, linear porokeratosis, punctate porokeratosis, solar facial porokeratosis and genital porokeratosis.Generalized variants are disseminated superficial porokeratosis, disseminated superficial actinic porokeratosis and disseminated palmoplantar porokeratosis. Unusual variants include hyperkeratotic porokeratosis, pruritic popular porokeratosis, verrucous porokeratosis (localized to buttocks) and reticulate porokeratosis. #porokeratosis #ask_drskin #skindisease #dermatology #trendingreels #viral2024 #funny #love

🔔 More research news coming from the #EADV2024 congress in Amsterdam! 👉 #EADVCongress Attendees, mark your calendars 📆 and make sure to add this e-Poster 📜 to your #EADV2024 itinerary: "Complementary effects of two botanical extracts on the Type 2-associated pruritogenic pathway in atopic dermatitis" (P0619) 🧪 Dive into our research exploring the anti-inflammatory potential of Rhealba® oat and Helichrysum gymnocephalum extracts. Discover their unique roles in modulating the inflammatory cascade and their specific actions against the pruritogenic biomarkers in atopic dermatitis. Our findings reveal promising therapeutic avenues for these extracts, particularly in the inhibition of the IL-31/TSLP axis, which is an important pathway involved in the itch sensation in atopic skin diseases. 📌 To find out more about research at #PierreFabreLaboratories, join our R&D and Medical Affairs teams at our “Research & Innovation Corner” (Booth B33) where they will share their expertise with dedicated presentations. 👏 Thanks to Fabrice LESTIENNE Lucile Garidou Nathalie Chansard Sandrine Bessou-Touya Hélène DUPLAN Fabienne Carballido Valérie Mengeaud Markéta SAINT AROMAN Pierre Fabre Laboratories #eadvcongress #dermatology #PierreFabre #NewWaysToCare #ResearchandInnovationCorner #atopicdermatitis #interactome #skincare #Aderma

Distinguishing squamous carcinoma in situ with deep endophytic growth Vs Nodular pushing invasion The distinction of deeply endophytic in situ squamous carcinoma from nodular pushing invasion is a difficult, contentious and occasionally subjective issue. The fundamental principle is that endophytic in situ disease can destroy tissue by “compressive” atrophy/ attenuation while true nodular tumour extends into dermis and subcutis albeit with a broad pushing front. A useful pointer to distinguish between the two is to note the quality of the interface and landmarks around the tumour, with respect to the native architecture of background skin. In deeply endophytic in situ disease, these landmarks are not destroyed but preserved, being pushed down and out of the way, with atrophy of the dermis between the advancing front of the tumour and the anatomical plane it has extended up to. There is also no host reaction/ immune response to the tumour which is still given the same level of immune privilege as non-endophytic in situ disease. By contrast nodular pushing invasion, tends to enter or obliterate landmarks which abruptly end around the tumour nodule at the same level as background skin, can incite and be associated with a distinct immune response and tumour cells (eg brisk lymphocytic infiltrate or eosinophils) can show distinct morphological changes (eg larger more pleomophic cells and lymphocyte induced apoptosis). #dermpath #dermtwitter #pathtwitter #pathresident #dermatologia #dermatology #dermatologist #pathologist #histopathology #surgpath #dermatopathologia #dermatopathology #dermatopathologist #medicine #medicalstudent #medicaleducation

🌟 Rare Disease Spotlight: Interstitial Granulomatous Dermatitis📚 A rare skin disorder in which there is a particular pattern of granulomatous inflammation. 🔔 The features of interstitial granulomatous dermatitis are variable. ◼ Red or skin-coloured patches, papules and plaques ◼ The shape of the lesions may be round, annular or cord-like. ◼ Lesions wax and wane, and may vary in size and shape over days to months. ◼ They are usually symptomless, but some patients complain of mild itch or burning sensation. ◼ The lesions tend to be symmetrically distributed on the trunk, but proximal limbs may also be affected. ◼ It most commonly affects middle-aged women. ◼ Many affected patients also suffer from autoimmune disease. 📌 Interstitial granulomatous dermatitis is diagnosed by a pathologist on examining a skin biopsy. The characteristic histological features of interstitial granulomatous dermatitis are: ✔ Dense histiocytic inflammation in the reticular (lower) dermis ✔ Sparse neutrophils and eosinophils ✔ Perivascular and interstitial lymphocytes ✔ Interstitial histiocytes (between the collagen bundles) or palisaded histiocytes (lined up perpendicular to fragmented central collagen). ✔ Focal degeneration of collagen, which may be surrounded by space (floating sign) ✔ Few giant cells. #Dermatology #SkinHealth #MedicalResearch #IGD #DermatologicConditions #HealthcareInnovation

Atopic dermatitis (AD) is the most frequent chronic inflammatory skin disorder affecting 20% of children and 5% of adults in industrialized countries. AD is frequently observed in early infancy, but the factors triggering AD development in infancy remain unknown. Infants with AD develop itchy lesions, particularly on the face, arms, and knees. For this study, researchers at Technical University of Munich in #Germany studied infants from birth till age 4. AD may involve a primary immune imbalance leading to Immunoglobulin E (IgE) sensitization or a skin barrier impairment. Alterations of the cutaneous microbiome may play an important role. The minimally invasive & virtually painless Neoteryx Harpera microbiopsy tool (IUO) from Trajan Scientific and Medical is being used in this investigational study to collect samples from a large cohort -- before, during & after recovery from AD. Read More>> #harpera #microbiopsy #dermatology #skindisease #dermatitis #skinsamples #MAPS #ScienceThatBenefitsPeople https://hubs.la/Q02w_5y-0

🌟 Rare Disease Spotlight: Pemphigus 🌟 A disease that causes blistering of the skin and the inside of the mouth, nose, throat, eyes, and genitals. Pemphigus is an autoimmune disease in which the immune system mistakenly attacks cells in the top layer of the skin (epidermis) and the mucous membranes. 📌 People with the disease produce antibodies against desmogleins, proteins that bind skin cells to one another. When these bonds are disrupted, skin becomes fragile, and fluid can collect between its layers, forming blisters. ⚡ There are several types of pemphigus, but the two main ones are: 🔶 Pemphigus vulgaris, which normally affects the skin and mucous membranes such as the inside of the mouth. 🔶 Pemphigus foliaceus, which only affects the skin. 📌 There is no cure for pemphigus, but in many cases, it is controllable with medications. #Dermatology #AutoimmuneDiseases #Pemphigus #MedicalResearch