Dr Mishil Parikh’s Post

#Chemotherapy is sometimes used to treat #VaginalCancer. Unlike Surgery and #RadiationTherapy, which only target specific areas, chemotherapy is a systemic treatment, meaning that it can destroy cancerous cells throughout the entire body. As a result, it is often used to address any cancerous cells that have started to spread. There are a number of different options for vaginal cancer chemotherapy. Most medications are infused into the bloodstream, but others are available as pills or topical lotions. While some patients are prescribed a single medication, most receive a combination of two or more chemo drugs. ~ What are the common side effects of chemotherapy? Side effects are common with chemotherapy, but it is important to know that they can often be controlled or even prevented. Most side effects go away over time after treatment ends. Side effects depend on the type and dose of #chemo you get and vary from person to person. Some common side effects include: · #Nausea and #vomiting · Mouth sores · #Constipation or #diarrhea · #HairLoss · Infections from low white blood cell levels · Easy bruising or bleeding from low numbers of platelets in the blood · Tiredness from low red blood cell counts · Loss of appetite · Dizziness · Skin problems, such as dryness, rash, blistering, or darkening skin · Tingling, numbness, or swelling in hands or feet (called #neuropathy) · Hearing problems · Kidney problems · Changes in #menstruation or ability to have children (fertility). Most people with vaginal cancer have already gone through #menopause. Most side effects will go away or get better between treatments and after treatment ends. But some can last longer or be permanent. There may be things you can do to help control some of these side effects. Tell your #Oncologist about any side effects you have. They can help you cope with them. For consultation with #GynaecologicOncologist, please call at ph +91 9820458696 or visit the website by clicking on the link https://buff.ly/3rXKU51

Do you know about bladder cancer? It's important to understand its symptoms and how to screen for it. Symptoms can include blood in your urine, pain when peeing, and frequent urination. If you notice any of these signs, talk to a doctor. Screening tests like urine tests or imaging scans can help detect bladder cancer early when it's easier to treat. Bladder cancer can show symptoms like blood in the urine (hematuria), pain or burning during urination, and frequent urination. However, these signs can also indicate other conditions, so it's crucial to consult a healthcare professional for a proper diagnosis. Contact No: 081300 14199 Website- https://lnkd.in/gpNMni28 Keywords : Best Endo Urology Care in sector B Lucknow, Best Uro oncology care near me, kidney Transplant near me, Best female Urology care Dr. Aditya sharma , Best pediatric Urology care, Best general Urology care near me, male infertility care near me, Urological Hospital near me. #BladderCancerAwareness #ScreeningSavesLives #KnowTheSigns #EarlyDetection #HealthAwareness #CancerScreening #GetChecked #SymptomsMatter #PreventBladderCancer #HealthyLiving #CancerAwareness #MedicalScreening #FightCancer #StayInformed #HealthyHabits

𝐖𝐡𝐚𝐭 𝐚𝐫𝐞 𝐭𝐡𝐞 𝐜𝐨𝐦𝐦𝐨𝐧 𝐛𝐞𝐧𝐢𝐠𝐧 (𝐧𝐨𝐧-𝐜𝐚𝐧𝐜𝐞𝐫𝐨𝐮𝐬) 𝐛𝐫𝐞𝐚𝐬𝐭 𝐜𝐨𝐧𝐝𝐢𝐭𝐢𝐨𝐧𝐬? Understanding common benign (non-cancerous) breast conditions is important for recognizing that not all breast changes indicate cancer. Here’s an overview of some of the most common benign breast conditions: ✅𝐅𝐢𝐛𝐫𝐨𝐜𝐲𝐬𝐭𝐢𝐜 𝐁𝐫𝐞𝐚𝐬𝐭 𝐂𝐡𝐚𝐧𝐠𝐞𝐬 𝐃𝐞𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧: This condition involves the presence of lumpy or rope-like textures in the breast tissue, often accompanied by breast pain and tenderness, especially before menstruation. ✅𝐅𝐢𝐛𝐫𝐨𝐚𝐝𝐞𝐧𝐨𝐦𝐚𝐬 𝐃𝐞𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧: These are solid, non-cancerous tumors that are smooth, firm, and movable. They are most common in young women. ✅𝐁𝐫𝐞𝐚𝐬𝐭 𝐂𝐲𝐬𝐭𝐬 𝐃𝐞𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧: Fluid-filled sacs within the breast tissue, which can be single or multiple and vary in size. They are common in women aged 35-50. ✅𝐌𝐚𝐬𝐭𝐢𝐭𝐢𝐬 𝐃𝐞𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧: An infection of the breast tissue, usually occurring in breastfeeding women. Symptoms include redness, swelling, pain, and sometimes fever. ✅𝐃𝐮𝐜𝐭𝐚𝐥 𝐨𝐫 𝐋𝐨𝐛𝐮𝐥𝐚𝐫 𝐇𝐲𝐩𝐞𝐫𝐩𝐥𝐚𝐬𝐢𝐚 𝐃𝐞𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧: An overgrowth of cells within the breast ducts or lobules, which can be classified as usual (lower risk) or atypical (higher risk) hyperplasia. ✅𝐈𝐧𝐭𝐫𝐚𝐝𝐮𝐜𝐭𝐚𝐥 𝐏𝐚𝐩𝐢𝐥𝐥𝐨𝐦𝐚𝐬 𝐃𝐞𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧: Small, wart-like growths in the ducts of the breast, often near the nipple. They can cause nipple discharge or a small lump. ✅𝐅𝐚𝐭 𝐍𝐞𝐜𝐫𝐨𝐬𝐢𝐬 𝐚𝐧𝐝 𝐎𝐢𝐥 𝐂𝐲𝐬𝐭𝐬 𝐃𝐞𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧: Fat necrosis occurs when fatty breast tissue is damaged, often due to injury, surgery, or radiation therapy. This can lead to firm, round lumps. Oil cysts can form when fat cells die and release their contents. 𝐓𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭: Usually monitored with imaging studies. In some cases, a biopsy may be performed to confirm the diagnosis. ✅𝐋𝐢𝐩𝐨𝐦𝐚𝐬 𝐃𝐞𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧: Soft, fatty lumps that are usually slow-growing and painless. They are composed of fatty tissue and are benign. ✅𝐂𝐨𝐧𝐜𝐥𝐮𝐬𝐢𝐨𝐧: While these benign breast conditions are not cancerous, they can cause symptoms that may be concerning. Regular breast self-exams, routine clinical exams, and appropriate imaging studies are vital for differentiation and management. If you notice any changes in your breasts or have concerns about breast health, consulting with a healthcare professional is essential. Dr. Jawad Mustafa, a breast health coach and OBGYN Ultrasound Consultant at Global Care Consult USA, can provide expert evaluation, diagnosis, and management tailored to your specific condition, ensuring comprehensive care and peace of mind. #globalcareconsult #breasthealth #livehealthy #breasthealthconsultation #selfcare #breasthealthguide #breasthealthawareness #preventiontips

𝐖𝐡𝐚𝐭 𝐚𝐫𝐞 𝐭𝐡𝐞 𝐜𝐨𝐦𝐦𝐨𝐧 𝐛𝐞𝐧𝐢𝐠𝐧 (𝐧𝐨𝐧-𝐜𝐚𝐧𝐜𝐞𝐫𝐨𝐮𝐬) 𝐛𝐫𝐞𝐚𝐬𝐭 𝐜𝐨𝐧𝐝𝐢𝐭𝐢𝐨𝐧𝐬? Understanding common benign (non-cancerous) breast conditions is important for recognizing that not all breast changes indicate cancer. Here’s an overview of some of the most common benign breast conditions: ✅𝐅𝐢𝐛𝐫𝐨𝐜𝐲𝐬𝐭𝐢𝐜 𝐁𝐫𝐞𝐚𝐬𝐭 𝐂𝐡𝐚𝐧𝐠𝐞𝐬 𝐃𝐞𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧: This condition involves the presence of lumpy or rope-like textures in the breast tissue, often accompanied by breast pain and tenderness, especially before menstruation. ✅𝐅𝐢𝐛𝐫𝐨𝐚𝐝𝐞𝐧𝐨𝐦𝐚𝐬 𝐃𝐞𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧: These are solid, non-cancerous tumors that are smooth, firm, and movable. They are most common in young women. ✅𝐁𝐫𝐞𝐚𝐬𝐭 𝐂𝐲𝐬𝐭𝐬 𝐃𝐞𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧: Fluid-filled sacs within the breast tissue, which can be single or multiple and vary in size. They are common in women aged 35-50. ✅𝐌𝐚𝐬𝐭𝐢𝐭𝐢𝐬 𝐃𝐞𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧: An infection of the breast tissue, usually occurring in breastfeeding women. Symptoms include redness, swelling, pain, and sometimes fever. ✅𝐃𝐮𝐜𝐭𝐚𝐥 𝐨𝐫 𝐋𝐨𝐛𝐮𝐥𝐚𝐫 𝐇𝐲𝐩𝐞𝐫𝐩𝐥𝐚𝐬𝐢𝐚 𝐃𝐞𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧: An overgrowth of cells within the breast ducts or lobules, which can be classified as usual (lower risk) or atypical (higher risk) hyperplasia. ✅𝐈𝐧𝐭𝐫𝐚𝐝𝐮𝐜𝐭𝐚𝐥 𝐏𝐚𝐩𝐢𝐥𝐥𝐨𝐦𝐚𝐬 𝐃𝐞𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧: Small, wart-like growths in the ducts of the breast, often near the nipple. They can cause nipple discharge or a small lump. ✅𝐅𝐚𝐭 𝐍𝐞𝐜𝐫𝐨𝐬𝐢𝐬 𝐚𝐧𝐝 𝐎𝐢𝐥 𝐂𝐲𝐬𝐭𝐬 𝐃𝐞𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧: Fat necrosis occurs when fatty breast tissue is damaged, often due to injury, surgery, or radiation therapy. This can lead to firm, round lumps. Oil cysts can form when fat cells die and release their contents. 𝐓𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭: Usually monitored with imaging studies. In some cases, a biopsy may be performed to confirm the diagnosis. ✅𝐋𝐢𝐩𝐨𝐦𝐚𝐬 𝐃𝐞𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧: Soft, fatty lumps that are usually slow-growing and painless. They are composed of fatty tissue and are benign. ✅𝐂𝐨𝐧𝐜𝐥𝐮𝐬𝐢𝐨𝐧: While these benign breast conditions are not cancerous, they can cause symptoms that may be concerning. Regular breast self-exams, routine clinical exams, and appropriate imaging studies are vital for differentiation and management. If you notice any changes in your breasts or have concerns about breast health, consulting with a healthcare professional is essential. Dr. Jawad Mustafa, a breast health coach and OBGYN Ultrasound Consultant at Global Care Consult USA, can provide expert evaluation, diagnosis, and management tailored to your specific condition, ensuring comprehensive care and peace of mind. #Drjawad #breasthealth #livehealthy #breasthealthconsultation #selfcare #breasthealthguide #breasthealthawareness #preventiontips

Is Total Disc Arthroplasty superior to Anterior Cervical Discectomy and Fusion in terms of Sagittal Balance? 💊 The debate between total disc replacement (TDR) and anterior cervical discectomy and fusion (ACDF) focuses on motion preservation versus stability in treating cervical disc herniation. TDR aims to reduce adjacent segment degeneration by maintaining motion, while ACDF provides reliable symptom relief through fusion. TDR offers better range of motion but risks complications like device subsidence, whereas ACDF is simpler with predictable outcomes but raises concerns about adjacent segment disease (ASD). The choice depends on patient-specific factors, including age, activity, and comorbidities. 📄 In this randomized controlled trial (RCT) of 98 patients, 48 patients received TDR whereas 50 patients underwent ACDF. These patients were followed-up on for at least 12 months and the outcomes evaluated were: ·        Total cervical mobility, ·        Neck range of motion (target and adjacent vertebra), ·        Cervical lordosis (CL, °), ·        Cervical sagittal vertical alignment (cSVA, mm), ·        First thoracic vertebra slope (T1 slope, °). 🔑 Key findings: 👉 Over a 12-month observation period, segmental range of motion was found to have no impact on changes in the regional or global balance of the cervical spine. 👉 Additionally, no correlation was observed between range of motion and the development of adjacent level syndrome, as no cases of the syndrome were diagnosed. 👉 The study demonstrated that arthroplasty with an Endocarbon endoprosthesis effectively improved cSVA and T1 slope values; however, it did not result in significant improvement in CL values compared to the ACDF group. 📖 Read the full #CochraneCentralRegister of #controlledtrials and #PlainLanguage summary in the #CochraneLibrary – https://lnkd.in/dRtn_UcB Eliseev AS, Bokov AE, Mlyavykh SG. Sagittal Balance Parameters after Anterior Cervical Discectomy with Spondylodesis and Arthroplasty Using Endocarbon Endoprosthesis: Results of Randomized Study. Sovrem Tekhnologii Med. 2022;14(4):50-57. doi:10.17691/stm2022.14.4.06 ❕ This study compared cervical total disc arthroplasty and anterior cervical discectomy and fusion, finding that segmental range of motion did not impact regional or global spinal balance or adjacent level syndrome development. While both procedures improved cSVA and T1 slope values, ACDF demonstrated superior improvement in cervical lordosis, whereas CTDA preserved motion at the operated segment. #CochraneReview #ControlledTrial #Cochrane #CochraneEvidence #EvidenceBased #cervical #ACDF

So a quick updated should we consider referring this lady to physiotherapy or not? L We should consider referring this patient to physiotherapy, as it could be a valuable management option, especially for improving muscle strength and spinal stability. However, it’s essential to ensure there are no red flags and that she is medically stable before proceeding. Gandhi et al. (n.d.) highlighted positive outcomes of physiotherapy in managing wedge compression fractures of the L1 vertebra. Moreover, Kato et al. (2022) identified abdominal muscle weakness as a significant risk factor for future osteoporotic vertebral fractures in middle-aged and older women. Resources https://lnkd.in/ecamXHfi. https://lnkd.in/enFv8Tkw

#Osteosarcoma, also called #OsteogenicSarcoma, is the most common type of #BoneCancer. ~What causes osteosarcoma? The direct cause of osteosarcoma is unknown. However, there are some risk factors, including: 1. Rapid bone growth: The risk of osteosarcoma increases during a child and adolescent’s growth spurts. 2. Exposure to radiation: This might have occurred from treatment for another type of cancer. This can take a few or several years to occur. 3. Genetic factors: Osteosarcoma is one of several types of rare cancers in young people. This may be related to the retinoblastoma gene, which can be associated with eye cancers in young children or with other #tumours in children and young adults in which a mutation of the p53 gene is involved. 4. Bone infarction: This happens when there is a lack of blood supply to your bone tissue. This destroys the cells. ~ Osteosarcoma Symptoms Warning signs of osteosarcoma include: • Swelling or lumps around bones or the ends of bones • Bone or joint pain or soreness (This pain may come and go for months. Each person can feel different degrees of bone pain, depending on where the cancer is located and if it has spread.) • Broken bones without a clear reason • Pain at night, often extreme • Pain after exercise • Limping • Respiratory or breathing problems if the cancer has spread to the lungs Talk to an Orthopaedic Oncologist if these signs do not go away in a couple of weeks or if they get worse. Knowing the risk factors and symptoms can help you catch osteosarcoma early before it has spread, helping make treatment more effective. Talk to an Orthopaedic Oncologist if you have any symptoms of osteosarcoma. For consultation with an #OrthopaedicOncologist, please call on ph 022 3547 5757 or click on the link https://buff.ly/3U7tfmT

𝗙𝗲𝗹𝗶𝗻𝗲 𝗢𝗿𝗮𝗹 𝗦𝗾𝘂𝗮𝗺𝗼𝘂𝘀 𝗖𝗲𝗹𝗹 𝗖𝗮𝗿𝗰𝗶𝗻𝗼𝗺𝗮 It is a Malignant tumor of Squamous Cell Epithelium. It is the most common Malignancy in Cats and is Locally Invasive. 𝗣𝗮𝘁𝗶𝗲𝗻𝘁: Jason, a 6 years old, male DSH 𝗛𝗶𝘀𝘁𝗼𝗿𝗶𝗰𝗮𝗹 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀: ● Mass effect ● Ptyalism ● Dysphagia ● Halitosis ● Poor grooming ● Bloody saliva ● Weight loss ● Hyporexia or avoidance of hard foods ● Misdiagnosed Congenital History (Siblings had same History like Jason, but they died due to misdiagnosis) 𝗣𝗵𝘆𝘀𝗶𝗰𝗮𝗹 𝗘𝘅𝗮𝗺𝗶𝗻𝗮𝘁𝗶𝗼𝗻 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀: ● Erythematous, ulcerated & fleshy lesion ● Facial swelling or deformity ● Minor Exophthalmos ● Pain on opening jaw ● Inflamed buccal mucosa ● Inflamed palatoglossal fold ● Bleeding with abnormal tissue growth ● Inflamed submandibular lymph node 𝗗𝗶𝗮𝗴𝗻𝗼𝘀𝗶𝘀: ● Swab Cytology Deformed nucleated cells ● FNA Multinucleated Cancer cells in Mitotic phase. ● CBC Erythrocytosis Lymphopenia High HB ● LFT & RFT Slight deviations from normal values 𝗧𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁: Chemotherapy (Protocol for Feline) 1) 𝙑𝙞𝙣𝙘𝙧𝙞𝙨𝙩𝙞𝙣𝙚 0.5-0.7 mg/m2 IV on weeks 1,2,3,4,7,10,13,16, 19, 22 and so on with 3 weeks gap. 2) 𝘾𝙮𝙘𝙡𝙤𝙥𝙝𝙤𝙨𝙥𝙝𝙖𝙢𝙞𝙙𝙚 200-250 mg/m² PO or IV ( give the day after Vincristine) on weeks 1,4,7,10,13,16,19 and so on with 3 weeks gap. 3) 𝙋𝙧𝙚𝙙𝙣𝙞𝙨𝙤𝙡𝙤𝙣𝙚 2 mg/Kg PO q24 hrs for 7 days, then 1.5 mg/ Kg PO 924 hrs for 7 days, then 1 mg/Kg PO q24 hrs for 7 days, then 1 mg/Kg PO q48 hrs throughout the protocol. ○ Cisplatin Contraindicated in Cats. (Surgical resection of tumor is also an option but minor tissue remnants can cause reoccurrence) 𝗣𝗿𝗼𝗴𝗻𝗼𝘀𝗶𝘀: Prognosis is poor even after Chemotherapy or Surgery with 10% survival rate. Post treatment Cats survive for 1 more year.

Our last work 👇🏻 Cervical cancer (CC) represents a significant health concern worldwide, particularly for younger women. Cold knife (CK) conization and carbon dioxide (CO2) laser conization are two techniques commonly used to remove pre-invasive lesions, offering a potential curative intent in cases of incidental diagnosis of CC. This study aimed to assess the clinical implications and pathological outcomes of CK vs. CO2 laser conization for pre-invasive lesions. We retrospectively analyzed women who underwent CO2 or CK conization for high-grade preinvasive lesions (CIN2/3, CIS and AIS) between 2010 and 2022. Patient demographics, surgical details and pathological outcomes were collected. Pregnancy outcomes, including composite adverse obstetric rates, and oncological follow-up data, were also obtained. In all, 1270 women were included; of them, 1225 (96.5%) underwent CO2, and 45 (3.5%) underwent CK conization. Overall, the rate of positive endocervical or deep margins was lower with CO2 laser compared to CK (4.3% vs. 13.3%, p = 0.015). Incidental CC was diagnosed in 56 (4.4%) patients, with 35 (62.5%) squamous and 21 (46.6%) adenocarcinomas. In a multivariate regression model, the relative risk for positive endocervical or deep margins is significantly greater in cases of incidental diagnosis of CC (p < 0.01). In cases of incidental diagnosis of CC, we found that the probabilities of having either positive endocervical or deep margins after CO2 laser or CK conization are similar, with a higher risk in case of adenocarcinoma lesion. Among women with CC, 42 (75%) opted for radical treatment, while 14 (25%) underwent a follow-up. Only one woman (7.1%) in the follow-up group, who had undergone CK conization, experienced a composite adverse obstetric outcome. No recurrences were observed after a median follow-up of 53 months. CO2 laser conization achieved a lower positive margin rate overall. CK and CO2 conization appear to be equivalent oncological options for incidental CC.

Let's shine a spotlight on something serious: kidney tumors. Ever felt that nagging pain in your side or noticed blood in your urine? These could be signs that something's up with your kidneys. But fret not, because there's hope! Understanding how kidney tumors are diagnosed and treated can make a world of difference. By staying informed and proactive, we can tackle these challenges head-on and pave the way for a brighter, healthier future. Kidney tumors, whether benign or malignant, can present symptoms like blood in urine, back or side pain, a lump in the abdomen, or unexplained weight loss. Diagnosis typically involves imaging tests like CT scans or MRIs, along with a biopsy to confirm if the tumor is cancerous. Contact No: 081300 14199 Website- https://lnkd.in/dbz5-uHc Keywords: Best Endo Urology Care in sector B Lucknow, Best Uro oncology care near me, kidney Transplant near me, Best female Urology care Dr. Aditya sharma , Best pediatric Urology care, Best general Urology care near me, male infertility care near me, Urological Hospital near me. #KidneyTumors #KidneyHealth #Diagnosis #TreatmentStrategies #CancerAwareness #MedicalCare #EarlyDetection #HealthAwareness #CancerTreatment #StayInformed #HealthyLiving #FightCancer #TreatmentOptions #CancerSupport #PreventionIsKey