Ph.D. in Medicinal Plants (Life Science) / M.Sc in Biotechnology / B.Sc in General Biology #Natural Products #Biotechnology #Stem Cells #Molecular Biology #Microbiology#Genetic Engineering#Drug Discovery
Agarose Gel Electophoresis. How to load the prepared samples(DNA, RNA,or Proteins) in the gel! samples mixed with loading dye are placed in the specific well in the agarose gel. #Agarose Gel Electophoresis #Electrophoresis #GenIran #Genetics #Loading dye
Struggling with Protein Synthesis? Not anymore! Try our step-wise tutorials that "chunk" the information so you can learn faster and retain information longer! RNA Transcription Tutorial: https://lnkd.in/gAhXPmCu #ditki #mcat #cellbiology #genetics #proteinsynthesis #meded #medicalscience #medicalschool #medstudent #rna #dna #biology #humanbiology #genbio
New research has discovered a family of RNA-guided DNA endonucleases - the IS607 TnpB protein family. These endonucleases show robust dsDNA interference activity in #bacteria and human #cells. The study demonstrated their #DNA cleavage activity and identified a 20-nt guide sequence that achieves the highest DNA cleavage activity for the ISFba1 TnpB enzyme. The study's findings open new opportunities for employing programmable endonucleases for #gene editing. Read the full article here: https://lnkd.in/d5dJWwd5 #geneediting #technology #innovation #cellresearch #CR
#genetics #medicine #medicalscience Episome Exogenous DNA that remains physically independent of the cell’s endogenous chromosome or complement of chromosomes. Depending on its content and context, #episomal #DNA may replicate or synthesize messenger RNA (and, indirectly, protein), thus conferring on the cell novel biologic properties. Episomal concatemers derived from adeno-associated virus (AAV) vectors are thought not to replicate.
Trivia Question: In the realm of CRISPR-based diagnostic tools, which novel technique utilizes the collateral cleavage activity of Cas13a to generate a fluorescent signal upon target RNA detection? A) CRISPR-Chip B) SHERLOCK C) CRISPR-on D) dCas9 #CRISPR #Biotechnology #Genetics #Diagnostics Sciqst, Precise References in Medicine. www.sciqst.com
Having your analytical workflow in optimal shape means nothing if your pre-analytics are not at the same level. Join the new scheme from EMQN CIC and SensID GmbH and learn how you are doing. #cfDNA #plasma #extraction
We have exciting news if you’re extracting circulating tumour DNA from plasma for genomic diagnostic tests! In collaboration with SensID GmbH, EMQN CIC has developed a new External Quality Assessment (EQA) / Proficiency Testing (PT) scheme for circulating tumour DNA (ctDNA) extraction from plasma. Since ctDNA has become a recognised alternative to tumour biopsy or resections as a source of testing material, a robust extraction and quantification method is necessary. Our scheme uses SensID’s latest plasma-based reference materials and will assess the extraction efficiency and quantification of the resultant nucleic acids. Don’t miss out as spaces are limited! To register your interest please complete the application form here: https://lnkd.in/e-bwV45x For more information, please read the full release on our website: https://lnkd.in/eHzBvVD9 #emqn #eqa #proficiencytesting #qualityassurance #molecularpathology #genetics #ctdna
NSTC is managed by IT Break Com Pvt. Ltd. and is India's premier organization working to promote the awareness of Nano-technology.
RNA Interference (RNAi) and siRNA Techniques Workshop Date: Dec 11-13, 2024 Time: 3:00 PM IST Format: Virtual Register Now: https://lnkd.in/g56XxRZw Know More: https://lnkd.in/gYfNCGqw #RNAi #siRNA #GeneSilencing #BiotechWorkshop #RNAInterference #GeneTherapy #MolecularBiology #siRNATechniques #RNAResearch #GeneExpression #TherapeuticApplications #CancerResearch #Genetics #siRNADesign #ViralInfections #GeneEditing
What services does UGenome Offer? Contact zachbrooks@ugenome.io for more information - Enhance sensitivity of mutation detection in next-generation sequencing data - Identify cell types and their molecular profiles #bioinformatics, #genetics, #rna-seq, #proteomics, #metaboloimcs, #differential-expression
What services does UGenome Offer? Contact zachbrooks@ugenome.io for more information - Enhance sensitivity of mutation detection in next-generation sequencing data - Identify cell types and their molecular profiles #bioinformatics, #genetics, #rna-seq, #proteomics, #metaboloimcs, #differential-expression
Seeking PHD : ||Food Microbiology|| ||Food safety and preservation|| ||Molecular biology ||Antimicrobialresistance|| #Aspiring Food and Industrial Microbiologist
Gel Electrophoresis of my PCR samples for ESBL resistant gene P-1 #PCR #Gelelectrophoresis #Microbiologist #Molecularbiology #Gene #ESBL
#CDK-independent role of D-type cyclins in regulating DNA mismatch repair:- •Although mismatch repair (#MMR) is essential for correcting DNA replication errors, it can also recognize other lesions, such as oxidized bases. In G0 and G1, MMR is kept in check through unknown mechanisms as it is error-prone during these cell cycle phases. •We show that in mammalian cells, D-type cyclins are recruited to sites of oxidative DNA damage in a PCNA- and p21-dependent manner. •D-type cyclins inhibit the proteasomal degradation of p21, which competes with MMR proteins for binding to PCNA, thereby inhibiting MMR. •The ability of D-type cyclins to limit MMR is CDK4- and CDK6-independent and is conserved in G0 and G1. •At the G1/S transition, the timely, cullin-RING ubiquitin ligase (CRL)-dependent degradation of D-type cyclins and p21 enables MMR activity to efficiently repair DNA replication errors. •Persistent expression of D-type cyclins during S-phase inhibits the binding of MMR proteins to PCNA, increases the mutational burden, and promotes microsatellite instability. #highlights :- •D-type cyclins are recruited to oxidative DNA lesions to inhibit MMR activity. •This role is present in G0 and G1 and is independent of CDK4 and CDK6 activity. •D-type cyclins’ degradation at G1/S ensures proper MMR activity during S-phase. •Absence of D-type cyclins in S limits mutational burden and microsatellite instability. #genetics #cellcycle #dnarepair #CDK4 #genomestability #molecularbiology
