Dr. Rahul S Kamble’s Post

As Sepsis Awareness Month concludes, we share the story of Jeroen Bursens, who almost lost his life to this deadly disease, a condition that kills about one-third of the 49 million people it affects annually. Jeroen's hospital-acquired infection that triggered sepsis after a routine surgery highlights the critical need for early detection and treatment. Thermo Fisher's diagnostic tools play a vital role in this fight and help clinicians make informed decisions and improve patient outcomes. As we wrap up Sepsis Awareness Month, let's commit to spreading awareness and supporting advancements in sepsis detection and treatment for people like Jeroen and his family. #SepsisAwarenessMonth

As Sepsis Awareness Month concludes, we share the story of Jeroen Bursens, who almost lost his life to this deadly disease, a condition that kills about one-third of the 49 million people it affects annually. Jeroen's hospital-acquired infection that triggered sepsis after a routine surgery highlights the critical need for early detection and treatment. Thermo Fisher's diagnostic tools play a vital role in this fight and help clinicians make informed decisions and improve patient outcomes. As we wrap up Sepsis Awareness Month, let's commit to spreading awareness and supporting advancements in sepsis detection and treatment for people like Jeroen and his family. #SepsisAwarenessMonth

As Sepsis Awareness Month concludes, we share the story of Jeroen Bursens, who almost lost his life to this deadly disease, a condition that kills about one-third of the 49 million people it affects annually. Jeroen's hospital-acquired infection that triggered sepsis after a routine surgery highlights the critical need for early detection and treatment. Thermo Fisher's diagnostic tools play a vital role in this fight and help clinicians make informed decisions and improve patient outcomes. As we wrap up Sepsis Awareness Month, let's commit to spreading awareness and supporting advancements in sepsis detection and treatment for people like Jeroen and his family. #SepsisAwarenessMonth

As Sepsis Awareness Month concludes, we share the story of Jeroen Bursens, who almost lost his life to this deadly disease, a condition that kills about one-third of the 49 million people it affects annually. Jeroen's hospital-acquired infection that triggered sepsis after a routine surgery highlights the critical need for early detection and treatment. Thermo Fisher's diagnostic tools play a vital role in this fight and help clinicians make informed decisions and improve patient outcomes. As we wrap up Sepsis Awareness Month, let's commit to spreading awareness and supporting advancements in sepsis detection and treatment for people like Jeroen and his family. #SepsisAwarenessMonth

As Sepsis Awareness Month concludes, we share the story of Jeroen Bursens, who almost lost his life to this deadly disease, a condition that kills about one-third of the 49 million people it affects annually. Jeroen's hospital-acquired infection that triggered sepsis after a routine surgery highlights the critical need for early detection and treatment. Thermo Fisher's diagnostic tools play a vital role in this fight and help clinicians make informed decisions and improve patient outcomes. As we wrap up Sepsis Awareness Month, let's commit to spreading awareness and supporting advancements in sepsis detection and treatment for people like Jeroen and his family. #SepsisAwarenessMonth

Our recent presentation at #CIDSCON 2024 Innovations in the Management of Difficult-to-Treat Bone Infections At **CIDSCON 2024** in Hyderabad, I had the opportunity to present a poster highlighting cutting-edge strategies in the management of **challenging bone infections** - role of multiplex PCR for early diagnosis & novel treatment options with good bone penetration, anti biofilm activity, tolerability especially when used for weeks & months ! 😊 Bone infections, particularly osteomyelitis, present complex treatment challenges due to resistant organisms and poor antibiotic penetration. However, **novel treatment modalities** are offering promising solutions. Key highlights from our presentation: 🔹 **Personalized treatment regimens** involving tailored antibiotic therapies based on culture sensitivities and infection kinetics. Use of novel antibiotics like levonadi 🔹 The role of **local antibiotic delivery systems** for enhanced efficacy in eradicating biofilms and achieving therapeutic concentrations. 🔹 Innovative surgical techniques, including **debridement and bone stabilization & stimulans to create an optimal environment for healing. This presentation emphasizes the importance of a **multidisciplinary approach**, integrating infectious disease specialists, microbiologists, and orthopedic surgeons, to achieve **better patient outcomes**. It’s the friendship which will bring good patient outcomes ! #InfectiousDiseases #BoneInfections #Osteomyelitis #CIDSCon2024 #NovelTherapies #ClinicalInnovation #PatientCare #AntibioticResistance #OrthopedicInfections

**Unlocking Healing Potential: Negative Pressure Wound Therapy (NPWT) for Traumatic Wounds** **Title: Healing with Vacuum: NPWT's Role in Traumatic Wound Recovery** **Background:** - 💔 Traumatic wounds, varying from minor cuts to complex fractures, challenge the healing process. - ⚙️ NPWT, a game-changer, applies negative pressure to aid wound management and reduce infection risk. **Objectives:** - 🤔 To evaluate NPWT's effects on open traumatic wounds across care settings. **Search Methods:** - 🔍 Exhaustive search in Cochrane databases, clinical trials registries, and reference lists. - 🌐 Language, date, and setting no bar. **Selection Criteria:** - 📚 Published and unpublished randomized controlled trials on NPWT for traumatic wounds. - 🎯 Primary outcomes: wound healing, infection, and adverse events. **Results:** - 📊 7 RCTs, 1377 participants; NPWT compared to standard care. - 🌐 Different studies for open fractures and other traumatic wounds. **Main Results:** *Open Fracture Wounds:* - Proportion of wounds healed at six weeks showed no clear difference (RR 1.01). - 🦠 NPWT's impact on wound infection uncertain (RR 0.48, I2 = 56%). - 💰 NPWT deemed not cost-effective for open fractures. *Other Open Traumatic Wounds:* - No clear difference in risk of wound infection (RR 0.61). - 🌐 Uncertain outcomes for different NPWT pressure levels. **Authors' Conclusions:** - 🔍 Moderate-certainty evidence shows NPWT doesn't significantly outperform standard care in wound healing. - 💰 Cost-effectiveness concerns raised for NPWT in open fractures. - ❓ Uncertainty persists on infection risk, adverse events, time to closure, surgery, pain, and quality of life. **In Summary:** - NPWT's efficacy and cost-effectiveness still under scrutiny. - 🌐 Ongoing exploration in wound care. Stay tuned for healing revelations! #NPWT #WoundCare 🌈💉

Infected F/BEVAR Explant Dear friends, Thank you again for the academic discussion about this case. Our decision to explant and stay out of the very purulent sac was based on the sac aspirant being frankly purulent and the microbiology consisting of gram positives, gram negatives and yeast (likely foregut source). Patient was treated with broad spectrum IV antibiotics and antifungals for a week prior to explant. Intraoperatively we noticed unexpected progression of infection transmurally into the supraceliac aorta. Our initial plan was to create a stump with the celiac beveled into it however the aorta, that looked ok on preop imaging, would not even hold a clamp and sutures kept tearing till I went about 6 centimeter above the celiac after temporary clamping above the branching allograft. There was pus within the wall of supraceliac aorta, something I have not seen before. Plan is to continue outpatient antibiotic and antifungal treatment for minimum of 6 months and continue interval imaging. This is our second instance of infection in a F/BEVAR in over 150 implants. Unfortunately graft infection, although rare, is something that we need to be prepared for. Strategies discussed on this thread are all appropriate options in different settings. I would love to hear more thoughts. #aortaed #unmvascularsurgery Gustavo Oderich MD Jesse Manunga Peter Gloviczki, MD, PhD Rafael Demarchi Malgor, MD, MBA FACS Faisal Aziz MD, MBA, FACS, Distinguished-FSVS Naveed Saqib Muhammad Aftab MD, FACS, FACC Ross Clark, MD, MBA, RPVI Firas Mussa

When the lung wheezing is gone the colon starts to cramp!! A 59-year-old male presented with a four-week history of intermittent abdominal cramps, tenesmus, and blood-mixed diarrhea. He reported having visited a nearby primary hospital, where he was treated with a five-day course of ciprofloxacin and metronidazole, resulting in partial improvement; however, his symptoms recurred after completing the antibiotics. Upon taking a detailed history, it was noted that he had experienced a cough, shortness of breath, and wheezing two months prior, for which he had been treated with steroids and salbutamol, leading to an improvement in his respiratory symptoms. Repeated stool microscopic examinations and cultures did not reveal any significant findings. After discussing the situation with the patient, a diagnostic colonoscopy was performed, which highly suggested the diagnosis, and histology confirmed it. The patient was treated with a 10-day course of metronidazole and a luminal agent, which led to significant improvement in his symptoms. Key message: Invasive amebic colitis after steroid treatment is one of the life threatening complications of a very common protozowa infection. Corticosteroids are an invaluable group of broadly prescribed anti-inflammatory medications, but have been identified as a risk factor for the development of fulminant amebic colitis. Improved awareness of this condition among medical providers is needed, so that infection with E. histolytica can be considered in both patients presenting with symptoms of colitis and patients with asymptomatic colonization prior to the administration of corticosteroids. Important article https://lnkd.in/e6BPFAsG Segenet Bizuneh University of Gondar #endoscopyunit