Ārepa’s Post

T4BBI Science News We are pleased to announce the publication of the inaugural article "Parageobacillus thermoglucosidasius as an Emerging Thermophilic Cell Factory," coauthored by one of our ten Ph.D. researchers Panos Kopsiaftis, who is working for the industrial Partner Corbion in the Netherlands and the Academic partner Wageningen University & Research. "This review explores the potential of the thermophilic microorganism Parageobacillus thermoglucosidasius for utilization in bio-based processes.  P. thermoglucosidasius demonstrates a versatile metabolism, enabling the degradation and utilization of the hemicellulose component in lignocellulose. Moreover, it possesses the ability to convert carbon monoxide (CO) into metabolic energy." "The growing attention around P. thermoglucosidasius has increased the number of molecular tools available for metabolic engineering of this species, and ultimately could lead to the development of cell factories with industrial relevance." Congratulations to Panos and his colleagues for contributing a most interesting review to the open world of science! Read the full article to explore the potential of this thermophilic microorganism and its implications for the advancement of biobased industries. Access the complete publication here: https://lnkd.in/de5VG3qV

I am pleased to highlight my recent research article with Prof. Hairui Yu. Our work examines the effect of Tea polyphenol on biochemical traits, growth, and immunological response in coho salmon.. https://lnkd.in/gwaCSPjy

"Mapping the complexity of the diet: circulating metabolites of plant bioactives abs food-gut microbiome-host interactions" My PhD project presented at the 28th Workshop on the Developments in the Italian PhD research on Food Science, Technology and Biotechnology HERE WE GO 💥

Pennovation Center member, Opertech Bio, announced the publication of their new research article, “Sodium-dependent glucose co-transport proteins (SGLTs) are not involved in human glucose taste detection”, published in the November 18, 2024 issue of the peer-reviewed journal PLOS ONE. It has been well established that sweeteners impart their taste by activating the TAS1R2/TAS1R3 “sweet taste receptor” in the tongue. A second signaling pathway involving the activity of glucose transporters, operating independently of the receptor, recently has been proposed for metabolizable caloric sweeteners. Opertech's TāStation® rapid throughput taste evaluation system was used to resolve a central question about sweet taste perception. “This Opertech-led research showcases TāStation®'s ability to tackle complex scientific problems with real-world commercial relevance.” said R. Kyle Palmer, Opertech’s Chief Science Officer and lead author on the paper. Read the full article here: https://bit.ly/3OiwSCA

The Nobel Prize in Chemistry 2024 highlights groundbreaking work in protein science 🏆🔬 Half for David Baker from University of Washington and Howard Hughes Medical Institute (HHMI), with his innovative creation of entirely new proteins, and the other half for the AI-driven model developed jointly by Demis Hassabis and John M. Jumper from Google DeepMind that predicts complex protein structures. These discoveries are game-changing, showing how proteins, made from amino acids, drive life’s essential processes and hold immense potential for medicine, sustainability, and more. Congratulations! 🎉 The Nobel Prize reinforces what the Ajinomoto Group has championed for years—the incredible potential of amino acids to create a positive impact as an essential part for living organisms. We have long understood the transformative power of amino acids and we are committed to continue contributing to the well-being of all the people, our society, and our planet with “AminoScience”. To read more about our “AminoScience” initiative by clicking the link below:   https://lnkd.in/gWQNR8p #WeAreAjinomotoGroup #EatWellLiveWell #NobelPrize2024 #AminoScience 

Researchers from Tel Aviv University, led by doctoral student Bruria Samuel (hronec) under the guidance of Dr. David Burstein, with contributions from Dr. Karin Mittelman, Shirley Croitoru, and Maya Ben Haim, have discovered a novel method to disable bacterial defense mechanisms, enabling the efficient transfer of genetic material between bacteria. This groundbreaking discovery could lead to the development of tools to address one of medicine's most pressing challenges- antibiotic resistance, and advance genetic manipulation techniques for medical, industrial, and environmental applications. Ramot's CEO, Dr. Ronen Kreizman, shared, “This research opens revolutionary possibilities in areas such as drug development against resistant bacteria, synthetic biology, agritech, and foodtech. The ability to control and fine-tune genetic material transfer between bacteria could become a powerful tool for addressing environmental, agricultural, and medical challenges. We are currently working on commercializing the technology and fully realize its transformative potential.” #antibiotics #resistingbacteria #grounbreakingresearch #research #innovation #researchinnovation #bacteria #antibioticresistance

How does the aging of nano/microplastics impact the proliferation of antibiotic resistance genes in sludge fermentation? Our PhD student Romana Saila looked into this as a part of her doctoral thesis research. Please check out our recent paper in the Science of the Total Environment journal.  https://lnkd.in/dDM7eD2h #Sludge #antibioticresistance #microplastics #nanoplastics

As a starting post for this year, I would like to share about #systemsbiology, a field that has become my research topic for around two years. Have you heard about it? Systems biology is a field that tries to observe living organism as an integrated system that can interact within the subsystems. Therefore, we expect that we can simulate perturbations in the system, such as the amount of drug dosage, and observe the effect of the drug holistically inside the living organism. That is only one scenario from many where systems biology can be useful for a better understanding of #bioprocess and metabolism. To unravel the biological complexity, we use mathematical models as the approach. Many methods can be applied; however, all methods should be in accordance with biological understanding; hence, the insights from the #modeling results can expand our knowledge of #biology. The rapid development in #bioinformatics allows us to combine several mathematical models to obtain a more comprehensive understanding. The diagram below is an example from Schnitzer et al. (2022) that integrates ODE, Boolean, and metabolic models to obtain better insights into protein damage accumulation. Integrating these models allows us to observe yeast metabolism using the metabolic model, together with protein damage accumulation over time using ODE and Boolean models. Realizing the potential of a multi-model approach, my current #research tries to integrate the ODE and metabolic model to find key factors in #biopolymer production by using bacteria. It is a challenging journey, but I believe it will be worth it in the end 😀

🔬 Exciting Research Update! 🌿 We’re thrilled to announce the publication of our latest research paper, “Enzymatic Glycosylation of 4′-Hydroxychalcones: Expanding the Scope of Nature’s Catalytic Potential,” now available in the International Journal of Molecular Sciences MDPI In this study, we dive into the enzymatic glycosylation of 4′-hydroxychalcones, exploring how this biochemical process enhances these compounds’ biological properties, including: • Improved Solubility: Glycosylation increases solubility, making 4′-hydroxychalcones more adaptable for use in various applications. • Nature-Inspired Catalysis: Our approach demonstrates the versatility of natural enzymes in modifying bioactive molecules, opening doors for sustainable and efficient biotechnological applications. 📘 Read the full paper here: https://lnkd.in/dhFszTaF to discover how these advancements might impact future therapeutic and nutraceutical developments. We encourage you to explore our findings and consider the potential of enzymatic glycosylation for innovation in health and wellness. Thank you to everyone who contributed to this exciting work. The research presented in this document was funded by the NCN Narodowe Centrum Nauki under grant number 2021/43/O/NZ7/01517. Additionally, the Article Processing Charge (APC) was covered by the Uniwersytet Przyrodniczy we Wrocławiu.

Majeed et al. just published: Using Carbohydrate-Based Polymers to Facilitate Testicular Regeneration in Journal Biology of the Cell. Carbohydrate-based polymers (CBPs) restore testis differentiation and downregulate apoptosis genes. CBP has biodegradability, low cost, and wide availability, but is at risk of contamination and variations. CBP shows promise in wound healing, but more research is required before implementation in healthcare.  https://lnkd.in/eNY--vmS