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The group of Christian Löw at EMBL Hamburg and Centre for Structural Systems Biology CSSB, with collaborators from the Christian-Albrechts-Universität Kiel, Centre national de la recherche scientifique and Université Paris Cité worked together to reveal the structure and function of a previously unknown lysosome transporter, MFSD1.   Lysosomes are organelles that function as a waste disposal and recycling system within the cell. They break down larger macromolecules such as proteins and lipids into smaller, lighter compounds, which are then transported into the cell’s cytoplasm.   The findings indicate that the transporter provides an alternative route to supply amino acids for biosynthetic pathways when other lysosomal amino acid exporters are overloaded. https://lnkd.in/d-ZEsFSH Katharina Jungnickel Markus Damme, Bruno Gasnier

Genetic insights shed light on how and where #bacteria form brightly coloured colonies without #pigments Some bacteria form colonies that display striking, reflective colours. New genetic insights into the formation of such colours allowed an interdisciplinary, international team of researchers to identify the environments and bacterial groups in which these colours are found. Doing so, the team has made a start in understanding the function of these colours in bacteria. The findings, which were published last week in the scientific journal Proceedings of the National Academy of Sciences (#PNAS), might have implications for the development of new innovative materials that use bacteria to replace non-sustainable dyes. Read more on this research by among others Bas E. Dutilh, Bastiaan von Meijenfeldt and Aldert Zomer: https://lnkd.in/eN-RekwB 📸 Colin Ingham, Hoekmine BV #uuscience #teamwork #innovation

A study published in the Current Opinion in Structural Biology 2024, dives into how Cryo-FIB is revolutionizing structural biology with enhanced resolution, and reduced sample damage. Here are the top 5 key findings and takeaways from the study. Swipe to read them. #CryoFIB #StructuralBiology #Innovation #Biotech #LifeScience #Research #ScienceNews #TechnologyAdvancements

🚀 Recreating the Birth of Complex Cellular Structures in Lab Settings! In a pioneering experiment detailed in Nature, scientists have successfully implanted bacteria into fungi, offering vital insights into how complex cellular structures like mitochondria and chloroplasts may have originated. 🔑 Key Takeaways: ◾ By inserting bacteria into fungal cells using a microscopic needle and a bike pump, researchers at the Swiss Federal Institute of Technology replicated early forms of symbiosis that might have led to major cellular developments over a billion years ago. ◾ This artificial symbiosis mimics natural processes that allowed early cells to develop specialized organelles responsible for energy production and photosynthesis. ◾ The experiment shows that such symbiotic relationships can be engineered in the lab, providing a model to study the origins and stabilization of these complex biological systems. 🌍 Why This Matters: Understanding how complex life evolved from simpler organisms can have a huge impact on biology, allowing scientists to potentially engineer organisms with beneficial traits, such as nitrogen fixation or carbon dioxide consumption. 🔗 https://lnkd.in/ezFZVMjp #CellBiology #SyntheticBiology #EvolutionaryBiology #ScientificResearch #Biotechnology

Have you wanted to dive into single-cell and/or spatial biology, but don't know where to start? Want to get great data for an affordable price? Check out these webinars from Fluent BioSciences Inc. and Curio Bioscience, hosted by Chameleon Science!

We're excited to introduce SymProFold! SymProFold enables rapid prediction of the repetitive supramolecular protein assemblies like bacterial and archaeal surface layers (S-layers) and viral capsids. These symmetrical protein assemblies act as protective shields for microorganisms / viruses. While traditional experimental methods for determining these structures could take months or years, SymProFold reduces this to a few hours. The SymProFold method also saves resources by allowing precise experiment design based on the predictions. In the Nature Communications paper, we describe the method and present 20 predicted structures, supported by experimental data. The potential applications are vast—from designing drugs to stop pathogenic bacteria from building their protective layers to innovations in nano-design for medicine, biosensors, and advanced coatings. Big thanks goes to the team – Christoph Buhlheller, Theo Sagmeister, Christoph Grininger and Nina Gubensäk!!! and collaborators Uwe B. Sleytr and Isabel Usón! Publication: https://lnkd.in/duiGYdD2 UniGraz: https://lnkd.in/dYqCpsak GitHub: https://lnkd.in/dy-eS_Cu Foto: Uni Graz/Tzivanopoulos #UniGraz #FWF #docfunds #BioMolStruct #SymProFold #ResearchInnovation #NatureCommunications #NAWIGraz #Slayers #Nanotechnology #AIinScience

A new paper is published in Current Biology. https://lnkd.in/gwRKg-c5 By collaborating with International teams, we evaluated how much the vertical occipital fasciculus (VOF), is a white matter pathway connecting the dorsal and ventral visual cortex, is preserved across mammalian species. Please also find a commentary from Dr. Jason Yeatman of Stanford University about our paper: https://lnkd.in/gx2We7XT

A new title has been added to our Springer Series on Biofilms: Biofilm Matrix, edited by Dr. Courtney Reichhardt, Washington University in St. Louis. You can read it here: https://lnkd.in/eQYSVhK5 This review covers essential topics such as: - Introduction to biofilm matrices and their components (biofilm matrixome). - Matrix structure, functionality and regulation - Recent advances and challenges in biofilm matrixome research. - The impact of matrix interactions on biofilm architecture and pathogen-host interactions - Biofilms, multicellular aggregates of microbes enclosed in an extracellular matrix, play a crucial role in both environmental and medical contexts. They can be beneficial, such as in wastewater treatment, but also pose significant challenges, such as chronic infections and antibiotic resistance. Understanding the biofilm matrix is key to addressing these problems. This book is a valuable resource for both established biofilm researchers and those new to the field. Whether you are looking to deepen your knowledge or are just starting your journey in biofilm biology, this book is for you! #Biofilm #BiofilmResearch #Microbiology #BiofilmMatrices #Science #Research

🔬 FEBS Open Bio Special Issue: Mitochondrial Biogenesis Research 🔬 Stay at the forefront of mitochondrial biogenesis research with the latest special issue from FEBS Open Bio. Dive into timely reviews on mitochondrial protein import, dynamics, and the role of oxidative phosphorylation. Perfect for students and researchers on mitochondrial biology, this collection offers key insights into the current state of understanding and the latest advancements in the topic. 👉 Access the full issue now: https://lnkd.in/eMMuWnMJ