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Driving Innovation in ADCs and Bispecifics | Supporting Industry Leaders

T-Cell Engagers: From Oncology to Autoimmune T-cell #engagers (TCEs), renowned for their success in #cancer therapy, are now gaining traction as a novel approach to treating #autoimmune diseases. While the use of #bispecifics for autoimmune indications is more advanced, the application of TCEs in this space marks an exciting frontier. The Challenge: Traditional treatments like #corticosteroids and alkylating agents often come with significant side effects and inconsistent #efficacy. Even targeted #therapies, such as #rituximab, can result in broad B-cell depletion due to the widespread expression of CD20. The Opportunity: TCEs offer a more targeted strategy, leveraging their unique mechanism to selectively eliminate #pathogenic #immune cells. Some Key Innovators: 🔸 Xencor & Janssen – Plamotamab (Phase 2) 🔸 IGM Biosciences, Inc. – Imvotamab (Phase 1/2) 🔸 Cullinan Therapeutics – CLN-978 (Phase 1) 🔸 Roche – RO7507062 (Phase 1) 🔸 EvolveImmune Therapeutics – EVOLVE205 (Preclinical) 🔸 Xencor – XmAb657 (Preclinical) Recent Deals Highlighting Industry Momentum: 🔹 Leads Biolabs & Oblenio Bio (Nov 7, 2024) – USD 614M potential deal value 🔹 GSK & Chimagen Biosciences (Oct 29, 2024) – USD 850M potential deal value 🔹 Merck & Co & Curon Biopharmaceutical (Aug 9, 2024) – USD 1.3B potential deal value 🔹 Genor & TRC 2004 (Aug 5, 2024) – USD 443M + royalties With significant partnerships forming, excited to see how TCEs will transform the treatment landscape for autoimmune diseases. #TCellEngagers #AutoimmuneDiseases #Immunotherapy #BiotechInnovation #Partnerships #MoA

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