ELSO (The Extracorporeal Life Support Organization)’s Post

Please check out my recent article based on my Master's thesis, published in the International Journal of Biological Macromolecules, titled "Production of Letrozole-Loaded Alginate Oxide-Gelatin Microgels Using Microfluidic Systems for Drug Delivery Applications." The primary objective of this study was to produce monodisperse, drug-carrying microgels capable of controlled drug release. To achieve this, we employed a stream-focused microfluidic chip featuring a coating current to prevent chip clogging. This innovative technique, used for the first time in our study, involved covering the dispersed polymer phase with an oily shield, effectively delaying the gelation process in the presence of a crosslinking agent. We selected Letrozole (LTZ) as the model drug for encapsulation in our microgels to achieve precise and controlled drug release. #DrugDelivery #DropletMicrofluidics #Microgels #AlginateOxide #ControlledDrugRelease Here is the link: https://lnkd.in/eUZFykuy

This new addition at our Zelle Research & Analytical facility, the Redshiftbio Apollo MMS system is an orthogonal and a more sensitive technique to FTIR and CD analysis for secondary structure analysis based on infrared spectroscopy. The technique can characterize aggregation, perform quantitation, stability structure and similarity analysis at high concentrations and in its native formulation (Contrary to FTIR and CD). Protein misfolds in secondary structure can occur during all phases of drug development. A protein misfold represents a structural impurity and at any level can result in changed efficacy and increase the potential for immunogenicity. Microfluidic Modulation Spectroscopy (MMS) is a powerful new infrared spectroscopy tool for protein structural analysis. . To know more write to us at projects@zellebiotech.com . #zellebiotechnology #IRspectroscopy #proteinstructure #analytical #connections #molecule #biosimilar #infrared #proteinstability #proteinaggregation #FTIR #research #zelleras Paresh TankReeti PriyadarshiniDrashti MehtaSanjukta TyagiShruti Kothari VoraSohum MohareSarita TripathiDipika PatelSelina PintoPavan GhaviNeha Mohite, MScSayali Malusare

Explore how DIMA Biotech’s cutting-edge DiMPro™ #Synthetic #Nanodisc platform is revolutionizing membrane protein research. Our vast collection of over 400 pre-stocked, pre-validated multipass membrane proteins—including GPCRs, transporters, and ion channels—delivers unparalleled purity and stability. These ready-to-use #nanodisc #proteins empower researchers to conduct precise experiments, accelerating drug discovery like never before. Watch this short video to discover the innovative technology driving synthetic nanodiscs and see how it can take your research to the next level. https://lnkd.in/gqUCCWHH

Characterising mRNA- and pDNA-loaded lipid nanoparticles using electrophoretic microfluidics: Christina Bailey-Hytholt at Worcester Polytechnic Institute and collaborators developed a method to rapidly and accurately analyze LNPs for optimized therapeutic loading by employing an electrophoresis microfluidic platform. It allowed for the analysis of LNP compositions with varying clinical lipid and nucleic acid formulations https://lnkd.in/eafdXx2r Their method quantifies the relative concentration of nucleic acid per LNP, making it potentially suitable for high-throughput characterization of LNPs during manufacturing and formulation research and development. An article also authored by Adriana Coll De Peña, Ph.D., Daniel Zimmer, Everett Gutterman-Johns, Nicole Chen and Anubhav Tripathi #LNP #mRNA #drugdelivery #microfluidics #Vesiculab

Precise shaking incubators for any labinfitek ICB-S1020 is a small bench-top shaking incubator that combines the functions of gas bath constant temperature and horizontal oscillation. It is widely used in the fields of biotechnology, microbiology, medical analysis, etc. Features: ✅Temperature range from Room temperature +5℃~60℃ ✅Timer settings from 1min~ 99h59min/∞ ✅Amplitude of 20mm

#Biology isn’t always an area we focus on here at #TorrScientific, but with our coatings for biosensors it caught our attention.   The purpose of our #Biosensors is for measuring metabolites, biomarkers and drugs in the interstitial fluid (the fluid found between cells, containing amino acids, glucose, oxygen and more). 🧪 These biosensors are constructed from minimally invasive sensors, with 4 electrodes of 16 “microspikes” each. A target analyte can be selected and measured as an electrical signal. For example, glucose, lactate and theophylline have previously been studied by Imperial College London. 🔬 Torr Scientific offers multiple options for coating to help reduce the noise of the electrical signal (the interference) leading to clearer measurements. 📶 To receive a quote for our coated biosensors, please get in touch with our sales team! 📨  https://lnkd.in/ej2FFSsh 📨 #VacuumOptics #VacOps #XEO #XRay #Biological #Electrode #Technology #Research  

What are the applications of our recombinant enzymes? We produce a wide range of enzymes, but much of our work with our partners is focused on enzymes that modify nucleic acid in some form, including polymerases, nucleases, and ligases. These essential enzymes are pivotal in the life sciences and healthcare sectors, driving medical advancements. Read the complete blog here: https://lnkd.in/gKu6gNkg Want to enquire about how we can help with your research projects? Fill out this form and we’ll reach out to you shortly: https://lnkd.in/gtxQd-yU #CocoonBioscience #Enzymes #LifeSciences #mRNA

Automated molecular optimization of BRD4 inhibitor using #AlphaFold2 predicted structure with our new #GenerativeAI drug design method, DrugHIVE. Recently published in the American Chemical Society #JCIM. We show that DrugHIVE can be used with AlphaFold2 structures to consistently generate molecules with strong binding affinity for the target crystal structure. This is critical given that AF2 currently provides confident predictions for 58% of the human proteome, including perhaps all unsolved foldable regions! Structure-Based Drug Design with a Deep Hierarchical Generative Model https://lnkd.in/gsGtNMGP code: https://lnkd.in/gUJ3JrE5 Remo Rohs lab. USC Dornsife College of Letters, Arts and Sciences. University of Southern California. #MachineLearning

🧬🔬 G protein-coupled receptors (GPCRs) are being intensely studied using small molecular tool compounds, although these often bind to the orthosteric site, complicating research. To overcome this, researchers developed ligand-directed labeling techniques that leave a reporter on the GPCR, allowing other ligands to bind. In their latest work, they applied this strategy to the adenosine A2B receptor (A2BAR), incorporating a N-acyl-N-alkyl sulfonamide warhead into a ligand without restricting A2BAR binding. Using SDS-PAGE, flow cytometry, and mass spectrometry, they found a probe that specifically labels A2BAR, despite some nonspecific protein labeling. Their efforts are paving the way for better GPCR detection tools. 🧪🔍 Illustrations were made using #protienimager Try Protein Imager: https://lnkd.in/dpT9hCK The paper: https://lnkd.in/dbi-A-XT #Biotech #Science #Research #GPCRs #Biochemistry #paper #article

More than half of all proteins are glycosylated, many of them at multiple sites. Did you know that already? Profiling of these glycosylation-related protein isoforms involves techniques to separate, identify, and quantify individual isoforms of glycoproteins and glycopeptides that are present in a biological specimen. Bruker's solutions, specifically the enablement of high-throughput processing empowered by the glyco-PASEF on timsTOF mass spectrometers, offer a cutting-edge approach for glycoprotein and glycan profiling. Empowering scientists with GlycoScape™ software and glyco-PASEF technology to achieve unparalleled precision in glycoprotein analysis. Follow the link for a unique opportunity to learn directly from Klaus Lindpaintner, Vice President, Glycobiology Solutions at Bruker. Key takeaways: 👩🔬 Discover how glyco-PASEF enables the precise targeting of glycopeptides, enhancing our understanding of glycoproteomics and its impact on disease mechanisms. 👨🔬 Learn about challenges in glycoproteomics and innovative solutions like GlycoScape™, which streamlines workflows by providing real-time glycoprotein identification readouts directly from your timsTOF data. #Science #Glycoproteomics #CancerResearch #timsTOF #GlycoScape #GlycoPASEF #Webinar #OnDemand #genuine #sciencecommunication