EuroscreenFast’s Post

Predicting the solubility of an active principle (the molecule with a therapeutic effect on patients) in mixtures of organic solvents is of paramount importance for the design, operation and optimization of drug manufacturing processes. In our new paper (https://lnkd.in/dyv2eRsk) we propose a novel approach based on supervised machine-learning, which is similar to quantitative structure-property relationship models, but where different solvent types are identified by molecular descriptors as UNIFAC subgroups, to perform solubility prediction. This is a collaboration between CAPE-Lab (Dipartimento di Ingegneria Industriale - DII UNIPD, Università degli Studi di Padova) and GSK, together with Francesca Cenci, Samir Diab, Paola Ferrini, Katy Harabajiu, Massimiliano Barolo, and Fabrizio Bezzo #machinelearning #capelab #pharma40 #unipd #dii #gsk

Watch an overview of NanoBRET™ technology for target engagement applications. While PROTACs might not be the topic of conversation at high society cocktail parties, or merit cover stories in glamour magazines, they’re certainly shaking up the drug discovery industry. PROTAC® degraders, together with related compounds like molecular glues and LYTACs, are the basic tools for a targeted protein degradation strategy. Research in this field is advancing rapidly. Discover more at https://bit.ly/3Ys2r2I #NanoBRET #PROTAC #ProteinDegradation

Let’s enable drug discovery together by embracing new possibilities in target acquisition and innovation, streamlining research processes, and achieving reliable, consistent results. And more is yet to come. What are you waiting for?

Organic bioactive molecules constitute an efficacious and safe class of therapeutics when compared to synthetic analogues. However, precise information about bioactivity and the relationship to their structure play an important role in the design of these therapeutics. Therefore, it is important to develop analytical methods and procedures that will answer the question: "what is the bioactivity?". Quantitative structure-retention relationships (QSRR) allow you to quantitatively evaluate the relationship between bioactivity and chromatographic retention. Prof Bogusław Buszewski will be discussing his work at #ISC2024, aimed at predicting the behavior of analytes in order to expand data sets when determining biological activity, membrane permeability, binding to serum proteins, and drug volume distribution using new generation columns.

😍Welcome again to our recurring showcase of #PICO products and services Presenting today our “PICO Amplification Core Kit”, which is the heart of the PICO assay. The streamlined workflow includes sample lysis, incubation of the lysed sample with the labeled #antibodies, and the #dPCR amplification for ultrasensitive readout. 💼The kit contains sufficient reagents for 120 or 480 PICO reactions in 24- or 96-well dPCR plates respectively. Together with the 4 different PICO Probes available, you can detect and quantify multiple protein targets simultaneously in a single PICO assay. Excited to know how PICO could replace cumbersome #westernblot and #coIP experiments? 📞Contact us today at info@actome.de and visit our webshop 👉 https://lnkd.in/dvmWjgbr to order the kit today. #nextgenerationdiscovery #proteinquantification #actome #research #interactomics #antibodies #biotechnology #proteinanalysis #innovation #dPCR #interaction #Qiagen

𝗨𝗻𝗹𝗼𝗰𝗸𝗶𝗻𝗴 𝗠𝗲𝗺𝗯𝗿𝗮𝗻𝗲 𝗣𝗿𝗼𝘁𝗲𝗶𝗻𝘀 𝘄𝗶𝘁𝗵 𝘁𝗵𝗲 𝗡𝗮𝘁𝗶𝘃𝗲𝗠𝗣™ 𝗧𝗮𝗿𝗴𝗲𝘁𝘀 Working with complex membrane proteins, like GPCRs and ion channels, is a major challenge in drug discovery. These targets are vital for many biological processes yet notoriously difficult to handle, especially when 𝗹𝗶𝗽𝗶𝗱 𝗶𝗻𝘁𝗲𝗿𝗮𝗰𝘁𝗶𝗼𝗻𝘀 and 𝗽𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝘁𝗲𝗺𝗽𝗲𝗿𝗮𝘁𝘂𝗿𝗲𝘀 add layers of complexity. This Summer, the NativeMP™ Targets have changed the game by maintaining membrane proteins in their native environment—enabling high-quality assays, deep insights into 𝗽𝗿𝗼𝘁𝗲𝗶𝗻-𝗹𝗶𝗽𝗶𝗱 𝗶𝗻𝘁𝗲𝗿𝗮𝗰𝘁𝗶𝗼𝗻𝘀, and application versatility at physiological conditions. We were already able to present data from a wide array of protein classes, acquired detergent-free, rapidly solubilized, and stabilized directly from the cell. Even large and complex targets, such as 𝗧𝗟𝗥𝟱, 𝗔𝗕𝗖𝗔𝟭𝟮, or coexpression of 𝗜𝗧𝗚𝗕𝟯/𝗔𝗩 have been possible. And more is yet to come. What are you waiting for? 👉 Let’s enable drug discovery together by embracing new possibilities in target acquisition and innovation, streamlining research processes, and achieving reliable, consistent results.   #drugdiscovery #membraneproteins #nativeMP

Join Bioprocess Online for best practices to ensure the analytical methods you're developing today are seamlessly transferrable tomorrow. Registration to this Roundtable Event is free thanks to the support of BD Biosciences. https://lnkd.in/emaVsRrb #flowcytometry #ELISA #electroporation #viraltransduction #techtransfer

#Digital_PCR Market Insights, Trends & Future Development Status Recorded during 2023-2032 >> https://lnkd.in/dbsCAyv2 #Digital PCR is a #quantitative PCR #technology that #measures the #quantity of #DNA or #RNA in a sample in a #sensitive and #repeatable manner. Digital PCR is a #biotechnological evolution of #conventional PCR. For sample #target #quantification, digital #PCR is a simple and repeatable technology that does not rely on a #calibration #curve. Bio-Rad Laboratories, 4basebio Fluidigm Sciences, Inc., JN Medsys, Merck KGaA, Darmstadt, Germany, QIAGEN N.V., Stilla Technologies, Sysmex Corporation, Combinati., Thermo Fisher Scientific #digitalpcr #biotechnology #medicalscience #dna #rna #scienceandtechnology

🚀 Are you looking to detect and quantify extracellular vesicles (EVs) with precision? 🔥Do you need high-quality labeled #antibodies for CD9, CD63, and CD81 detection in your PICO experiments? 🔬 Look no further—our Labeled EV Antibodies (EV-LABs) are here for you. Our EV-LABs are specifically selected and tested high-quality antibodies labeled with PICOglue Labels. Analyze your EV markers seamlessly with PICO technology using our EV-LABs. Eager to see how EV-LABs can enhance your EV analysis? Order them today 👉 https://lnkd.in/eiCict-Q 👈 📞 For any further information, feel free to write to us at sales@actome.de. #nextgenerationdiscovery #proteinquantification #actome #research #interactomics #antibodies #biotechnology #proteinanalysis #innovation #dPCR #interaction #dnasequencing #extracellularvesicles