Frank Brunkhorst’s Post

📢New Special Issue launched! Addressing Coagulation and Inflammation to Prevent and Treat Ischemic Stroke 🔗 https://lnkd.in/gdNjQsjy 👨🔬Guest Editor: Prof. Antonino Tuttolomondo 📅Deadline: November 30, 2024 Welcome to submit your work to discuss together! As an author, you can benefit from Google Scholar, CAS, and DOAJ indexing, open access publication, and no Article Processing Charges before July 31, 2026. Plus, authors retain copyright, and the research will be widely promoted. This special issue will summarize the role of inflammation in the pathogenesis of ischemic stroke and the involvement of the main coagulative factors involved in estrinsic and intrinsic mechanisms of the coagulation in brain ischemic damage. Contact for more information and submission details: entjournal@explorationpub.com #callforpaper #ischemic #stroke #inflammation #coagulation #hemostasis #thrombosis

how immunometabolism becomes a perspective in understanding the pathophysiology of T2DM https://lnkd.in/gWRgRmQ4

What's new in the field of monoamine oxidases, mitochondria and inflammation ? 🤔 Check out our last review recently published in Redox Biology ! 😊 🔬 #mitochondria #inflammation #mitoDAMPs #monoamineoxidases

Molecular pathophysiology of the antiphospholipid syndrome: the role of oxidative post-translational modification of beta 2 glycoprotein I https://t.co/QWRGbLxlM2 #EurekaMag

📢 Data on Immunic's drug candidate in celiac disease published in 𝙏𝙝𝙚 𝙇𝙖𝙣𝙘𝙚𝙩 𝙂𝙖𝙨𝙩𝙧𝙤𝙚𝙣𝙩𝙚𝙧𝙤𝙡𝙤𝙜𝙮 & 𝙃𝙚𝙥𝙖𝙩𝙤𝙡𝙤𝙜𝙮! 📢 We are pleased to share that our phase 1 data in healthy human subjects and phase 1b data in patients with celiac disease from our clinical trial of IMU-856 has been published in this prestigious peer reviewed journal. ▶ https://bit.ly/3AFIX1w The article around lead author, Dr. A. James Daveson, Gastroenterologist, Wesley Research Institute and Coral Sea Clinical Research Institute, Queensland, Australia provides insights into IMU-856’s phase 1 clinical profile and its potential to support gut health and restore barrier function – key challenges in celiac disease. The Lancet #Immunic #IMUX #Gastroenterology #CeliacDisease #Celiac #IMU856

📢Interesting Article: Pathomechanisms and Treatment Implications for Stroke in COVID-19: A Review of the Literature 🎓 by Dr. Stamm et al., from the Northwestern University Feinberg, USA. 👉Enjoy reading: https://lnkd.in/dS-K9CNa #COVID-19; #acute ischemic stroke; #pathomechanism stroke

This week’s #onlywithHCR Series spotlights the Zhu et al. (2024) publication, “Loss of dihydroceramide desaturase drives neurodegeneration by disrupting endoplasmic reticulum and lipid droplet homeostasis in glial cells.” #HCRimaging enabled Zhu et al. to discover that infertile crescent (ifc) expression is widely expressed throughout the central nervous system of the fruit fly. Explore their manuscript on bioRxiv & medRxiv in more detail here: doi.org/gt6qmx 

The underlying cause of Long COVID is still a puzzle to researchers. But Akiko Iwasaki, PhD, Sterling Professor of Immunobiology and Molecular, Cellular, and Developmental Biology at Yale School of Medicine (YSM) and co-lead investigator of the Yale RECOVERY and Yale LISTEN studies, has theories. Iwasaki explains that Long COVID is an “umbrella term” and likely has “multiple mechanisms that are not mutually exclusive” and may even coexist. She provides explanations for four predominant hypotheses being explored that may explain the condition. Read more in the latest installment of “Long COVID Dispatches from the Front Lines with Lisa Sanders, MD”: https://brnw.ch/21wKfNQ #blog #LongCovid #covid

Breakthrough in COVID-19 Research by Rosangela Silva Santos (USP - Universidade de São Paulo) Awarded Best Short Oral Presentation at Redox Medicine 2024 🏆! Dr. Silva Santos's research at the University of São Paulo revealed that arachidonic acid (AA) treatment significantly increases PGF2α production in SARS-CoV-2 permissive lung cells. This suggests a crucial role for PGF2α in COVID-19 pathophysiology. Dr. Santo's results could pave the way for new therapeutic approaches in COVID-19 and other inflammatory diseases. 🔗 Learn more about the award-winning talks: https://lnkd.in/dZ452-XT 🔁 Missed the conference? Watch the replay and follow up with the award-winning talks. https://lnkd.in/dEqDyhHF 🌐: https://lnkd.in/dsCEQThq #RedoxMedicineSociety #RedoxMedicine2024 #redox #rms #ArachidonicAcid #Oxylipins #COVID19 #AwardWinner #LungHealth #InflammationResearch

📢 Our #review paper "External and internal exposome as triggers of biological signalling in systemic sclerosis – A narrative synthesis" is now online. 🔗 https://lnkd.in/gc-p9VDQ 👉 The studies discussed in the present review clearly show advances in understanding of SSc disease phenotype and associated biomarkers in relation to specific pathophysiological features and biological processes. However, most of the reviewed studies evaluating internal exposome markers are not supplemented with external exposome data. 👉 In EXIMIOUS_H2020 project, we have establish population-based case control study with patients with #SystemicSclerosis (SSc). The patients have been recruited from the University Hospitals of Leuven and Louvain (Belgium).  A major emphasis has been placed on characterization of a large number of external exposome parameters covering different aspects of current occupational exposures (measured and modelled), occupational history, socioeconomic factors, hobbies, housing condition and air pollution modelling among others. 🔜 Stay tuned for results from our cohort. Lisa Janssen, PhD, Frauke Lemaire, Chiara Longo, François Huaux, @Steven Ronsmans, Peter Hoet, Manosij Ghosh #Exposome #EHEN #EXIMIOUS