Claudie Gabillard’s Post

Excited to share that the focus of my doctoral research is officially published! While Nrf2 is often discussed in the context of redox biology, we show it also plays a crucial role in controlling dendritic cell inflammatory responses and influences T cell skewing during respiratory superinfection. If you are interested, you can read more here:

The underlying cause of Long COVID is still a puzzle to researchers. But Akiko Iwasaki, PhD, Sterling Professor of Immunobiology and Molecular, Cellular, and Developmental Biology at Yale School of Medicine (YSM) and co-lead investigator of the Yale RECOVERY and Yale LISTEN studies, has theories. Iwasaki explains that Long COVID is an “umbrella term” and likely has “multiple mechanisms that are not mutually exclusive” and may even coexist. She provides explanations for four predominant hypotheses being explored that may explain the condition. Read more in the latest installment of “Long COVID Dispatches from the Front Lines with Lisa Sanders, MD”: https://brnw.ch/21wKfNQ #blog #LongCovid #covid

From MBoC WHAMM functions in kidney reabsorption and polymerizes actin to promote autophagosomal membrane closure and cargo sequestration The actin cytoskeleton is essential for many functions of eukaryotic cells, but the factors that nucleate actin assembly are not well understood at the organismal level or in the context of disease. To explore the function of the actin nucleation factor WHAMM in mice, Campellone et al. examined how Whamm inactivation impacts kidney physiology and cellular proteostasis. https://lnkd.in/etakrRYB

„The search for effective therapy for sepsis: back to the drawing board?“ (Derek Angus, JAMA, 2011). Any progress made over 13 years ? Latest epistemiological and biological view on further perspectives in sepsis research is published here: https://lnkd.in/eK58RnzK #sepsis #research #archetypes #endotypes #phenotypes #subgroups #mortality #studydesign #predictiveenrichment #clinicaltrials

Biology is complex: The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants

🎉✨️🎉✨️ I am thrilled to share that our latest manuscript, "The Effect of Helicobacter pylori-Derived Extracellular Vesicles on Glucose Metabolism and Induction of Insulin Resistance in HepG2 Cells," has been published in the esteemed "Archives of Physiology and Biochemistry" by Taylor & Francis Group. In this study, we explored how extracellular vesicles derived from Helicobacter pylori can induce insulin resistance in HepG2 cells. Our findings reveal a novel mechanism by which these vesicles impact glucose metabolism, highlighting the intricate relationship between this bacterium and metabolic disorders. Babak Yadegar Parvaneh Saffarian Mojdeh Hakemi Vala amir sadeghi Link of the paper: https://lnkd.in/dQTGuvif #Helicobacter_pylori, #insulin_resistance, #Extracellular_vesicles

Unraveling IFN-I response dynamics and TNF crosstalk in the pathophysiology of systemic lupus erythematosus https://lnkd.in/g78JgU3v

I am proud to share that my first article on how 𝐒𝐩𝐚𝐬𝐭𝐢𝐧 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐞𝐬 𝐄𝐑-𝐦𝐢𝐭𝐨𝐜𝐡𝐨𝐧𝐝𝐫𝐢𝐚𝐥 𝐜𝐨𝐧𝐭𝐚𝐜𝐭 𝐬𝐢𝐭𝐞𝐬 𝐚𝐧𝐝 𝐦𝐢𝐭𝐨𝐜𝐡𝐨𝐧𝐝𝐫𝐢𝐚𝐥 𝐡𝐨𝐦𝐞𝐨𝐬𝐭𝐚𝐬𝐢𝐬 is out and available to read on 𝒊𝑺𝒄𝒊𝒆𝒏𝒄𝒆. 👉 https://lnkd.in/e45usJwd 📎 Spastin (SPG4) is a protein associated with most of the cases of hereditary spastic paraplegia (HSP), a neurological disorder characterized by progressive spasticity and weakness of lower limbs. The main function of spastin is the severing of microtubules in smaller fragments. This article talks about how the level of spastin expression influences the number of contact sites between ER and mitochondria but also affects mitochondria morphology, calcium homeostasis, mitochondrial membrane potential, oxygen species levels, and oxidative metabolism. All my collaborators and co-autors for the work we did and for theses amazing experiences: sonia missiroli, Peggy Sanatine, Dominique Langui, Julien Pansiot, Nissaï Beaude, Lucie Vezzana, Rachelle Saleh, Ph.D., Martina Marinello, Mireille Laforge, Paolo Pinton, Ana Buj Bello and of course my PhD supervisor Andrea Burgo. All this was made possible with Genethon and APSHE (Aide à la recherche médicale contre la Paraplégie Spastique Héréditaire et Nos Enfants). #spastin #spg4 #mercs #mam #hsp #neurodegeneration #raresdiseases #research #apshe

This groundbreaking discovery reveals a previously unrecognized role of platelets in mediating the clearance of senescent red blood cells (RBCs) from the bloodstream via platelet RBC complexes (P-RBCs). It expands our understanding of platelet physiology beyond their classical function in clot formation. This article explores the intricacies of this newly identified platelet function and its potential implications for both physiological processes and disease states.