[#news] 📢 Exciting news for leprosy treatment. De Jong’s team at Institute of Tropical Medicine Antwerp (Antwerp, Belgium) has recently published promising Phase 2 trial results in PLOS Medicine, highlighting the safety of a preventive treatment combining bedaquiline and rifampicin for leprosy. In line with this progress, we at GenoScreen (Lille, France) have integrated the atpE gene - a key resistance marker for bedaquiline in M. leprae - into our diagnostic assay, Deeplex® Myc-Lep. This enhancement boosts our test’s ability to assess potential resistance to this novel preventive treatment, helping to reach the goals of the World Health Organization roadmap “Towards zero leprosy by 2030”. 📄 Read the study here: https://lnkd.in/envPEHzm With the updated Deeplex Myc-Lep, GenoScreen continues to lead in the fight against leprosy. ➡️ Learn more about Deeplex Myc-Lep: https://lnkd.in/etF_H3TB #Leprosy #Diagnostics #Genomics #GenoScreen #DeeplexMycLep #WHO2030 #deeplex Have questions or want to learn more about our solutions? We're here to support your research and projects! 📧 Email: commercial.dept@genoscreen.fr 📞 Phone: +33(0) 362 263 777 🌐 Visit our website: https://lnkd.in/eXesRaKY
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Given the complexity of sarcoidosis and the various factors that influence the disease, we are on the verge of significant scientific breakthroughs by uniting patients' genetic data from diverse ancestral backgrounds. Although this challenge may seem daunting, a global collaboration, including dedicated colleagues from Sweden, the Netherlands, Portugal, Greece, Spain, the Czech Republic, Finland, Estonia, Italy, Norway, Denmark, France, Belgium, Germany, Türkiye, Romania, Serbia, Poland, Latvia, Moldova, the United States, Japan, South Korea, India, and South Africa, along with partners like the #Foundation For Sarcoidosis Research, empowers us to advance genetic research on sarcoidosis and shape its future. #Sarcoidosis #PatientCare #Healthcare #Genetics #Medicine #EPOS (European Association of Patients Organizations of Sarcoidosis and other Granulomatous Disorders ) #ACSI (Amici contro la Sarcoidosi Italia ETS) #MESARGEN #interstitiallungdisease #ild #interstitial #lung #disease #Innovation #DataScience #BigData #PrecisionMedicine #SarcoidosisResearch #SarcoidosisAwareness #CuttingEdgeResearch #InnovativeDiagnostics #ResearchForACure #HopeForSarc #SarcWarriors #AdvancingScience #PatientFocused #WASOG
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Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance. https://lnkd.in/dJxnE7xn Dr. Matthew J Shepherd, PhD, Taoran Fu, Niamh Harrington, Anastasia Kottara, PhD, Kendall Cagney, James Chalmers, Steve Paterson, Jo Fothergill & Michael Brockhurst. Nature Reviews Microbiology In this review, the authors explore the clinical evidence to support four major mechanisms of within-patient AMR emergence in bacteria: spontaneous resistance mutations; in situ horizontal gene transfer of resistance genes; selection of pre-existing resistance; and immigration of resistant lineages. Within-patient AMR emergence occurs across a wide range of host niches and bacterial species, but the importance of each mechanism varies between bacterial species and infection sites within the body. They identify potential drivers of such differences and discuss how ecological and evolutionary analysis could be embedded within clinical trials of antimicrobials, which are powerful but underused tools for understanding why these mechanisms vary between pathogens, infections and individuals. Ultimately, improving understanding of how host niche, bacterial species and antibiotic mode of action combine to govern the ecological and evolutionary mechanism of AMR emergence in patients will enable more predictive and personalized diagnosis and antimicrobial therapies. #antimicrobialresistance #AMR #infectiousdisease #antibiotics
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Ecological and evolutionary mechanisms driving within-patient emergence of #antimicrobialresistance.
Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance. https://lnkd.in/dJxnE7xn Dr. Matthew J Shepherd, PhD, Taoran Fu, Niamh Harrington, Anastasia Kottara, PhD, Kendall Cagney, James Chalmers, Steve Paterson, Jo Fothergill & Michael Brockhurst. Nature Reviews Microbiology In this review, the authors explore the clinical evidence to support four major mechanisms of within-patient AMR emergence in bacteria: spontaneous resistance mutations; in situ horizontal gene transfer of resistance genes; selection of pre-existing resistance; and immigration of resistant lineages. Within-patient AMR emergence occurs across a wide range of host niches and bacterial species, but the importance of each mechanism varies between bacterial species and infection sites within the body. They identify potential drivers of such differences and discuss how ecological and evolutionary analysis could be embedded within clinical trials of antimicrobials, which are powerful but underused tools for understanding why these mechanisms vary between pathogens, infections and individuals. Ultimately, improving understanding of how host niche, bacterial species and antibiotic mode of action combine to govern the ecological and evolutionary mechanism of AMR emergence in patients will enable more predictive and personalized diagnosis and antimicrobial therapies. #antimicrobialresistance #AMR #infectiousdisease #antibiotics
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🔬#OneDayOneGenome BRIC-National Institute of Biomedical Genomics has sequenced the genome of Enterococcus faecalis OG-20, a bacterium often implicated in infections among immunocompromised patients. The E. faecalis genome, at 2.6 million base pairs and containing 2,579 genes, offers crucial insights into antibiotic resistance and virulence factors. This breakthrough could be key to developing new strategies to manage and treat infections in vulnerable populations. #AntibioticResistance #WAAW #Genomics #ResearchAndDevelopment #PublicHealth #OneHealth Rajesh Gokhale
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Join us for an insightful webinar on "Unleashing the Potential of Genomics to Unravel Multiple System Atrophy" with Sonja W. Scholz, MD, PhD! 🧬 Discover how the latest advances in genomic technologies are revolutionizing MSA research. Reserve your spot: https://lnkd.in/gM8EuZb9 #MSA #msaawareness #multiplesystematrophy #raredisease #webinar #healthwebinar #education #research #genomics #rarediseasewebinar #msawebinar #health #healtheducation Parkinson's Disease rare disease PSP PD
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Day 8 of TGen's Top 20: New Insights into Liver Disease Genetics with Johanna DiStefano Led by Johanna DiStefano, Ph.D., TGen’s latest study uncovers key genetic drivers of MASLD and MASH, liver diseases affecting millions. This breakthrough meta-analysis reveals new potential therapeutic targets and helps predict which patients are at risk of developing severe liver damage. With these findings, TGen is paving the way for more precise treatments in the fight against liver disease. 🧬🔬 To learn more: https://bit.ly/4f8lgxc #Science #Research #Genomics #Impact #Technology #Innovation #Hope #Arizona #foryoupage #fyp
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📢 New findings from our ALS disease studies presented by Principal Disease Biologist, Andy Malinowski, at the Motor Neurone Disease (MND) Association's 35th International Symposium on ALS/MND. 🧬 Our mechanism-based stratification of sporadic ALS patients' WGS data uncovered new disease drivers in genetically defined patient subgroups, paving the way for more personalized diagnostics and effective #PrecisionMedicine treatments. 👏 Thank you to all of our research partners, patients, and advocates for making this possible. ➡️ View the poster: https://lnkd.in/ekpNGzHz #PrecisionNeuroscience #ALS #MND #alsmndsymp #CountdowntoaCure
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There's a lot of buzz around a new paper shedding light on modern genetics and inflammatory diseases. Here's a quick summary: 🌟 Major Challenge: Translating GWAS success into better disease understanding remains one of modern genetics' biggest hurdles. 🧬 Key Focus: ETS2's pro-inflammatory effects on genes, studied through its disruption and overexpression in human macrophages. 🔍 Findings: * ETS2 drives pathogenic macrophage phenotypes. * Detailed mechanisms of ETS2’s impact on inflammation unveiled. 💡 Treatment Insights: * Traditional approach: Blocking individual cytokines. * Emerging strategy: Targeting multiple cytokines simultaneously for better results. ⚙️ Mechanism Highlight: * Inhibiting ETS2 signaling via MEK1/2 affects multiple cytokines like TNF, IL-23, and IL-1β. 🛠️ Innovative Approaches: * Recent advancements in bi-specific and tri-specific Abs is addressing multiple cytokine targetting. * Potential strategies: * Targeting ETS2 directly with PROTACs. * Selective MEK inhibitor delivery to macrophages via antibody-drug conjugates. Potential proposed strategies in the article needs to be tested! https://lnkd.in/ehbkrc3y #Translationalresearch #IBD #Genetics
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Proud to have featured Fasciola nyanzae, liver fluke of the hippo🦛, in Trends in Parasitology! Together with Tine Huyse
The 2024 June issue of the Cell Press journal Trends in Parasitology https://bit.ly/2N9R8Es reviews hookworm genomics (Vladislav Ilík & Barbora Pafčo), hepatocyte-intrinsic immune responses against Plasmodium (Samarchith Kurup), Anopheles stephensi identification (Tamar Carter), genetic approaches to curing mosquitoes (George Dimopoulos), prevention of canine vector-borne diseases (Domenico Otranto), and NGS technologies for helminth diagnostics and surveillance in ruminants (Alistair Antonopoulos); Spotlights from Kyle Cunningham, PhD and George Yap; Parasite of the Month: Fasciola nyanzae (Ruben Schols); Vector of the Month: Ixodes scapularis (Risa Pesapane); Special highlights on the first Cryptosporidium meeting (Amandine Guérin & Chelsea Marie Braun) and the Drug Design & Development Seminar 2024 (Paul M. Selzer).
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