Department of Biotechnology’s Post

🚨 New Research Alert 🚨 A recent study sequenced 24 complete mitochondrial genomes from healthy individuals in Bosnia and Herzegovina, focusing on the MT-ATP6 and MT-ATP8 genes crucial for energy production. Using advanced next-gen sequencing technology, researchers identified 11 SNPs, none of which were linked to mitochondrial diseases. These findings provide valuable insight into genome variation in European populations and pave the way for future clinical applications in mitochondrial DNA analysis. #MitochondrialGenetics #Research #Genomics #HealthScience #Biotechnology Nejira Handzic Naida Mulahuseinović Ivana Ceko Izmirlija Mirza Adna Ašić Lana Salihefendić Rijad Konjhodzic 👏

Take advantage of our incredible offer and save 20% on PacBio Human Whole Genome Sequencing. Confidently identify causative pathogenic variants and novel disease-associated genes with the power of HiFi long-read sequencing. With an accuracy of 99.9% per base, uncover complete, accurate, and phased assemblies of the human genome, including regions previously inaccessible to other technologies. Don't miss out. Contact us today to learn more. Learn more: https://lnkd.in/g8a8xAqe Contact us: https://lnkd.in/gA5SxFFm #genomics #agrf_genomics #PacBio #humangenome #longreadsequencing

💥 NEW - Published: 18 October 2024 🧬🔬👨🎓🧩👍🧬💚👨🌾📈💚 - Diverse epistatic effects in barley-powdery mildew interactions localize to host chromosome hotspots - Valeria Velásquez-Zapata, Schuyler Smith, Priyanka Surana, Antony V.E. Chapman, Namrata Jaiswal, Matthew Helm, Roger P. Wise, - iScience, Volume 27, Issue 10, 2024, 111013, ISSN 2589-0042, https://lnkd.in/deEYBmF5 #Blumeriahordei #powderymildew #Mla #NLR #resistance #Genomics #cereals #barley #plantpathology Abstract: Summary Barley Mildew locus a (Mla) encodes a multi-allelic series of nucleotide-binding leucine-rich repeat (NLR) receptors that specify recognition to diverse cereal diseases. We exploited time-course transcriptome dynamics of barley and derived immune mutants infected with the powdery mildew fungus, Blumeria hordei (Bh), to infer gene effects governed by Mla6 and two other loci significant to disease development, Blufensin1 (Bln1), and Required for Mla6 resistance3 (rar3 = Sgt1ΔKL308-309). Interactions of Mla6 and Bln1 resulted in diverse epistatic effects on the Bh-induced barley transcriptome, differential immunity to Pseudomonas syringae expressing the effector protease AvrPphB, and reaction to Bh. From a total of 468 barley NLRs, 115 were grouped under different gene effect models; genes classified under these models localized to host chromosome hotspots. The corresponding Bh infection transcriptome was classified into nine co-expressed modules, linking differential expression with pathogen structures, signifying that disease is regulated by an inter-organismal network that diversifies the response. Keywords: Biological sciences; Immunity; Plant biology; Plant Genetics

Velsera and Sentieon’s Pangenotyper has won the Best-of-Show award at Bio-IT World 2024! Pangenotyper is revolutionizing NGS data analysis with unprecedented accuracy and efficiency. By overcoming the limitations of traditional linear reference genome analysis, Pangenotyper ensures more accurate identification of genetic variants across diverse populations, reducing costs and processing times. Key Benefits:  🔸 Higher accuracy in variant detection  🔸 Faster processing times  🔸 Cost-efficient analysis  🔸 Compatibility with standard formats and tools     Whether you're in biopharma, clinical research, or population health studies, Pangenotyper can transform your genomic data analysis, uncovering actionable insights and driving personalized medicine forward. Learn more about how Pangenotyper can enhance your research today: https://lnkd.in/eHg9kSGN #BioITWorld #NGS #Genomics #PrecisionMedicine #Pangenotyper  

COMMENT PIECE: ‘Rare disease genomic testing: promoting timely and equitable access’. In this article, Dr Sarah Wynn and Professors Sian Ellard, Emma Baple and Rob Taylor discuss the recently published Position Statement on the best practice for ensuring consistent delivery of genomic testing for rare diseases. Read the full comment piece for free on our website: https://lnkd.in/etk7J_r3 To share your thoughts on this article all you need to do is follow the link, sign in and leave a comment – why not give it a try today. #genomics #genetics #DNA #

🌟 New Research Alert! 🌟 Explore Mitophagy-Related Genes in Sepsis! Our latest article, “Identification of Mitophagy-Related Genes in Sepsis,” uncovers critical insights into how mitochondrial autophagy can influence the onset and progression of sepsis. 🔍 Key Findings: Identified four key genes associated with mitophagy: TOMM20, TOMM22, TOMM40, and MFN1. Provides a foundation for future biological studies aimed at sepsis treatment. Published in Volume 19, Issue 8, 2024, this open access article is now available! 👉 Read it here: https://bit.ly/4dWpjvL Join us in advancing the understanding of sepsis and its treatments! #Sepsis #Mitophagy #MitochondrialHealth #OpenAccess #MedicalResearch #Biology #Inflammation #Healthcare #Genomics #ProteinInteraction

💥 NEW - Published: 18 October 2024🧬🔬👨🎓🧩👍🧬💚👨🌾📈💚 - Diverse epistatic effects in barley-powdery mildew interactions localize to host chromosome hotspots - Valeria Velásquez-Zapata, Schuyler Smith, Priyanka Surana, Antony V.E. Chapman, Namrata Jaiswal, Matthew Helm, Roger P. Wise, - iScience, Volume 27, Issue 10, 2024, 111013, ISSN 2589-0042, https://lnkd.in/deEYBmF5. #Blumeriahordei #powderymildew #Mla #NLR #resistance #Genomics #cereals #barley #plantpathology Abstract: Summary Barley Mildew locus a (Mla) encodes a multi-allelic series of nucleotide-binding leucine-rich repeat (NLR) receptors that specify recognition to diverse cereal diseases. We exploited time-course transcriptome dynamics of barley and derived immune mutants infected with the powdery mildew fungus, Blumeria hordei (Bh), to infer gene effects governed by Mla6 and two other loci significant to disease development, Blufensin1 (Bln1), and Required for Mla6 resistance3 (rar3 = Sgt1ΔKL308-309). Interactions of Mla6 and Bln1 resulted in diverse epistatic effects on the Bh-induced barley transcriptome, differential immunity to Pseudomonas syringae expressing the effector protease AvrPphB, and reaction to Bh. From a total of 468 barley NLRs, 115 were grouped under different gene effect models; genes classified under these models localized to host chromosome hotspots. The corresponding Bh infection transcriptome was classified into nine co-expressed modules, linking differential expression with pathogen structures, signifying that disease is regulated by an inter-organismal network that diversifies the response. Keywords: Biological sciences; Immunity; Plant biology; Plant Genetics

💡 Exciting insights from recent research at University of Catania on predicting antimicrobial resistance in Klebsiella pneumoniae using machine learning! This study used the Watchmaker DNA Library Prep Kit with Fragmentation and emphasizes the critical role of genomic data in addressing the issue of antibiotic resistance. 🦠 Read the full article for more details: https://ow.ly/AXYo50U84mT #AntimicrobialResistance #Genomics

Unlocking the Power of CRISPR: Insights from "CRISPR Chronicles" Webinar I recently attended the enlightening "CRISPR Chronicles: Rewriting Genetic Diversity In Disease" webinar, exploring the transformative potential of CRISPR technology in disease treatment. Key Learnings : - CRISPR-Cas9 mechanisms and applications - Genetic diversity's role in disease causation and treatment - Latest advancements in CRISPR-based therapeutics Thank You Grateful to Miss Prerna Mehta (Ambassador of Microbiologists Society, India)organized by Sci Bug for sharing valuable expertise. #CRISPR #GeneEditing #GeneticDiversity #DiseaseTreatment #Webinar #ProfessionalDevelopment #Genomics #Biotechnology

Explore how whole genome and transcriptome data are driving advancements in fusion and somatic variant detection. Hear from experts: 🔹 Katherine Miller, PhD (Nationwide Children’s Hospital): Discover the power of whole transcriptome sequencing in delivering sensitive fusion detection. 🔹 Stephanie Ferguson (Inocras): Learn how target-enhanced whole genome sequencing is differentiating tumor-specific changes from inherited sequences to boost detection accuracy in diverse populations. Don’t miss these valuable insights at #AMPath24 — register today! https://ow.ly/5qr650U6q2e Add to iCal: https://ow.ly/vYGQ50U6q2b #Genomics #NGS #FFPE