HKSTP - Hong Kong Science and Technology Parks Corporation’s Post

https://lnkd.in/eeBZ9weg VitalDose® EVA Implants for Systemic & Local Delivery of Therapeutics: Cyonna Holmes, PhD, Karen Chen, MS, and Brian Duke explain how systemic delivery approaches that leverage continuous dosing can address adherence issues and improve drug effectiveness while minimizing adverse reactions, and how a localized delivery approach can minimize total drug exposure, reduce off-target toxicities, and overcome targeting issues.

Primary human hepatocytes are indispensable tools for liver-related# research and therapeutic development. Read our latest #blog post to explore the top 10 applications of these cells in basic research, drug development, and regenerative medicine. Read now: https://ow.ly/luVJ50UgYoy #CredibleConversations

🚩 40-50% of clinical failure of drug development is due to lack of clinical efficacy. 🧬 Obatala Sciences offers two physiologically relevant HUMAN-derived organoid models that recapitulate the in vivo responses of adipose tissue in vitro. Our ObaCell® Fat-on-a-Chip and ObaCell® Obesity-on-a-Chip platforms allow for high-throughput screening of drug candidates, saving resources and time while bringing therapeutics to the market faster. 📈 Are you ready to expedite product development and make your research clinically translatable? 🔔 Reach out to us today on LinkedIn or email us at info@obatalasciences.com for more information on our adipose models. 💻 See our website here: https://lnkd.in/gxgbSeYV #OrganOnAChip #AdiposeMPS #Biotech #ClinicalEfficacy #HighThroughputDrugScreening #DrugDevelopment

Congratulations to PrevEp, Inc. on their NINDS Phase I #SBIR award for a project titled "Treatment of status epilepticus and refractory status epilepticus with intravenous topiramate". Having developed a novel #topiramate formulation (PrevEp004) amenable to intravenous administration, the company aims to test the capacity of PrevEp004 to terminate #statusepilepticus (SE) and #refractorystatusepilepticus (RSE). The preclinical work will include testing tolerability, safety, and efficacy of the novel intravenous formulation of topiramate in a clinically relevant rat model of RSE. #Epilepsy

Unlock the secrets to revolutionizing oligonucleotide development with groundbreaking insights into the oligotherapeutics market. Discover why many oligos haven't reached the market and identify the bottlenecks slowing you down.  Whether you're among the 50% stuck in preclinical stages or still navigating discovery, this resource is packed with vital stats, tips, and strategies to propel you forward. Accelerate Your Research Today! https://hubs.la/Q02DBCX-0 #Pharma #PrecisionMedicine #siRNA #ASOs #mRNA

🧠🔬 Progress in the Study of Anti-Alzheimer's Disease Activity of Pyrimidine-Containing Bioactive Molecules 💊✨ Synopsis: Pyrimidines, aromatic heterocyclic compounds with a six-membered ring, exhibit various biological activities, including antifungal, antiviral, and anti-Parkinsonian effects. Recent research highlights their potential anti-Alzheimer's properties. Several pyrimidine-based drugs are in clinical trials, showing promise for drug development. Structural modifications, such as introducing heteroatoms or altering linkage lengths, enhance their efficacy against Alzheimer's. This review covers pyrimidine derivatives, focusing on structure-activity relationship (SAR) studies, design strategies, and binding mechanisms, paving the way for effective anti-Alzheimer's medications. Source: Yu-Lin Liu et al., European Journal of Medicinal Chemistry https://lnkd.in/grGqbCss #AlzheimersResearch #Pyrimidines #DrugDevelopment #MedicinalChemistry #BioactiveMolecules #Neurodegeneration #PharmaceuticalResearch #InnovativeTherapies #Chiralpedia

Researchers, how would you propose to progress drug delivery systems for the posterior inner eye segment? Your solutions should ensure sustained release over at least three months for diverse therapeutics ranging from low molecular weight compounds to complex molecules. Learn more on our open science platform #opnMe: https://lnkd.in/gEDjfkdd

H.C Weinwright analyst: #CardiolRx Poised for the Final Stretch; Initiating With a Buy Rating and $9 PT (1) CardiolRx is a Phase 2 stage, pharmaceutical-grade, proprietary cannabidiol oral solution in development as a treatment for recurrent #pericarditis (RP) and acute #myocarditis (AM); (2) Cardiol’s use of a deliberate, scientific evidence-based approach to CardiolRx clinical advancement creates a significant barrier to entry; and (3) CardiolRx targets RP and AM, heart disease indications with significant unmet medical need with high potential to make CardiolRx a blockbuster drug that we forecast could achieve >$1.3B in peak annual sales. #CRDL #Cardiol #HeartDisease #CVD

This innovative study explores repurposing rosiglitazone by encapsulating it in liposomes to safely target and deplete monocytes, showing promise for treating inflammatory disorders with minimized cardiovascular risks. You can check it out here: https://lnkd.in/ge5nmTeE #Innovation #Technology #Healthcare #MedicalResearch #Biotechnology #Pharmaceuticals #DrugDevelopment #Nanotechnology #Inflammation #CardiovascularHealth

In Part 1 of his #BusinessofBiotech interview, with Matthew Pillar and Anna Rose Welch, Tal Zaks, chairman and CEO of Exsilio Therapeutics, discusses the critical role of innovation and intellectual property in the biotech ecosystem. He highlights that while unmet medical needs guide the focus of therapeutic development, the source of true innovation comes from scientific curiosity and technological breakthroughs. He uses the development of lipid nanoparticles as an example of how a foundational scientific discovery can lead to impactful therapies. Dr. Zaks also discusses how return on investment is vital for supporting high-risk innovation, as well as the value of generic medicines and their role in making therapeutics widely available. This thought-provoking discussion sheds light on the drivers of the biotech industry. Watch on YouTube: https://lnkd.in/gZU7CRpg Or watch online: https://lnkd.in/gZaPgP7N #Biotech #BioPharma #Innovation #IntellectualProperty #ScientificDiscovery