UC San Diego HUMANOID: Center of Excellence in Human Organoid Research’s Post

Deep Learning on #organoids (#PDO) #risks 'garbage-in-garbage-out'. A 5-point strategy (👇read more) implemented at UC San Diego HUMANOID: Center of Excellence in Human Organoid Research #derisks this process: 1) A deep #biobank that is #representative of #disease and #healthy population; 2) Engage in #prospective biobanking (#learned behavior of #PDO should be related back to patient #outcome!); 3) Respect #epigenetics (e.g., iPS models of a gut, have no knowledge of the environment being modeled) and reduce #artifacts (when it comes to additives, less is more); 4) #Benchmark PDOs against a mathematically defined, omics-derived #precise and #invariant aspect of the diseased tissue, and these invariant #features are of the highest value for #SupervisedLearning; 5) Sift #information guided by #physicianscientists and SMEs in the disease area to know what is clinically #important and #actionable. Katherine Johnson, the remarkable NASA mathematician, once wisely stated, “In math, you're either right or you're wrong.”.... "Math is the same. If I gave you that answer last year, it's the same now". CELLphenomics GmbH; Molecular Devices; HUB Organoids; Curie.Bio; Biopico Systems INC; Emulate, Inc. Organovo Holdings, Inc.Vyant Bio; Hesperos Inc. Cherry Biotech Encapsulate; Tempus AI; Parallel Bio

Organoid models have accelerated the development of drug screening methodologies. However, it is important to be wary of phototoxicity. Dr Valeria Chichagova, PhD, Director of Technology, spoke to Biocompare to share some top tips on minimizing or eliminating phototoxicity: 🔹Utilize low-intensity illumination by using the lowest possible light intensity that still provides clear images to reduce cellular stress and damage. 🔹By optimizing imaging protocols to limit the duration and frequency of light exposure, researchers can further reduce exposure time. Furthermore, near-infrared fluorophores are less damaging to cells compared to visible light fluorophores. 🔹Advanced imaging techniques, such as light sheet fluorescence microscopy offers gentle, low-phototoxicity imaging, ideal for long-term studies. 💬 “Advanced algorithms for image analysis enhance the ability to extract quantitative data from complex organoid structures, improving the accuracy of phenotypic assessments. Techniques such as content-aware image restoration improve image quality and resolution from lower quality raw data.” Read the full article here: https://lnkd.in/eBm3v95n #Newcells #Organoids #Retina #Phototoxicity

We can't wait to see you for SNMMI this weekend in Toronto! You can schedule a meeting with us in advance here : https://lnkd.in/gaBrpUki Stop by booth SB2 in small business pavilion to learn about our new : - Reagents (new iodinated vitamin E based Fenestra HDVC) - In Vivo Imaging Systems (2D and/or 3D, bioluminescence + fluorescence + SWIR) - Accessories (Mvein Restrainer for Tail Vein Injections) - Services (Tail Vein Injection Dosing) - Softwares (Imalytics Preclinical Image Analysis) #invivoimaging #preclinicalimaging #lifesciences #molecularimaging

Laser Capture Microdissection Market worth $306 million by 2029 Download PDF Brochure: https://lnkd.in/dpxdNq3d The global laser capture microdissection market in terms of revenue was estimated to be worth $184 million in 2024 and is poised to reach $306 million by 2029, growing at a CAGR of 10.6% from 2024 to 2029. Global Laser Capture Microdissection Market Dynamics ✅ DRIVER: Increase in R&D funding ✅ RESTRAINT: Requirement of high degree of technical expertise ✅ OPPORTUNITY: Integration with omics technologies ✅ CHALLENGE: Time-consuming sample preparation process 𝐓𝐡𝐞 𝐜𝐨𝐦𝐩𝐚𝐧𝐢𝐞𝐬 𝐟𝐞𝐚𝐭𝐮𝐫𝐞𝐝 𝐢𝐧 𝐭𝐡𝐢𝐬 𝐫𝐞𝐩𝐨𝐫𝐭 𝐢𝐧𝐜𝐥𝐮𝐝𝐞 Thermo Fisher Scientific Danaher Corporation ZEISS Group Standard BioTools JSR Corporation Bio-Rad Laboratories, Agilent Technologies, Bruker Molecular Machines Ocimum Biosolutions Theralink Technologies, Inc. 3DHISTECH - The Digital Pathology Company, Creative Biolabs DeNova Sciences Pte Limited Laxco, Inc. Caresbio Laboratory LLC VitroVivo Biotech, LLC AnaPath Services GmbH & AnaPath Research S.A.U. GNOME DIAGNOSTICS LLC QIMA Monasterium GmbH Independent Forensics Norgen Biotek Creative Bioarray Epistem Ltd. #ErectileDysfunction #MedicalDevices #MenHealthCare #UrologyCare #HealthcareInnovation

Ex vivo, before clinical study can perform out of the living, the procedures performed on tissues or organs extracted from a living organism and conducted outside the original biological context. These experiments are conducted in a laboratory setting, where the biological material is maintained in conditions that mimic those found within the organism as closely as possible. A simpler ex vivo definition would be taking a piece of a puzzle to look at it closely. Ex vivo models are frequently used for disease modeling, Drug Discovery and Development, regenerative medicine, and tissue engineering. Ex vivo and in vitro models represent an excellent alternative to animal testing. Next review article can define more for the new type of experiments on contract the results of in vitro models. https://lnkd.in/dNbi54_Q #Ex_vivo #Regenerative_medicine #Drug_Discovery #3D_Cell_Culture

This Valentine’s Day let’s celebrate a different kind of connection – between science and progress.    Researchers are developing a new type of technology that could reshape cardiovascular drug development, offering a more efficient and ethical path forward.    Called Heart-on-a-Chip, the tech works by replicating intricate interactions of human heart cells. As we mark this day of love, let’s also applaud the dedication of scientists worldwide collaborating to advance healthcare solutions.    Check out the news story for more info on this technology: https://lnkd.in/g8HiyPWX    #ValentinesDay #Bioscience #Biomedicine #Nanotechnology

📍 NEW APP NOTE | Discover how our #Gri3D plates enable high-throughput and #reproducible organoid culture, analyzed with the latest tools: 🔬 High-resolution imaging of 3D organoid structures with the #ImageXpress Micro Confocal system. 📊 Advanced image analysis with #INCarta software, enabling precise organoid segmentation and feature extraction. AI-powered clustering of organoid features using #StratoMineR, revealing insights into drug efficacy. 🧪 Organoid models sourced from Doppl SA biobank, with many more models available for research. Want to dive into the full details? Contact us (enquiries@sunbioscience.ch) or our collaborators to get your copy of this NEW app note 📩 Molecular Devices Doppl SA Core Life Analytics #Organoids #HighThroughput #3DCellCulture #DrugDiscovery #Collaboration #PDOs #Screening

Did you know your eyes can detect a single photon of light thanks to rod cells?   These specialized cells in the retina are essential for night vision, helping us see in low-light conditions. Unlike cone cells, which detect color, rod cells are highly sensitive to light but don’t perceive color, making them vital for seeing in the dark.   With Dragonfly 3D World, rod cells can be segmented from complex retinal tissue and visualized in high-resolution 3D. This detailed view allows for a deeper understanding of how the cells are structured and function, opening the door to potential innovations in vision-related technologies.     #RodCells #NightVision #Dragonfly3D #3DModeling #EyeHealth #CellSegmentation #Retina #Biological #Imaging #Bioimaging #FIBSEM

Organoid technologies are being seen as a game-changer in #DiseaseModeling and #DrugScreening. However, challenges associated with the practical adoption of organoid cell culture have limited their wider adoption as a primary screening method in #DrugDiscovery. In this exciting new webinar from Molecular Devices, experts will discuss #TheFutureOfCellCulture and introduce a revolutionary new automated solution that gives labs the confidence in experimental outcomes – for both 2D and 3D research – to make key decisions sooner, achieve milestones faster, and get to the clinic earlier with lower attrition rates. Register here to learn more: https://bit.ly/3wChLi1 #3DBiology #LabAutomation #AutomatedWorkflow #CellXpressAI #AD

We're excited to announce that our Izon Science automated Fraction Collector (AFC) machine is now available for rental use at the MD1 Flow Cytometry Facility, NUS Yong Loo Lin School of Medicine! For just $15 per sample (excluding GST), you can streamline your exosome isolation process and save valuable time by renting our AFC. How it works: 1. Purchase qEV columns from the facility. 2. Make a booking to utilize the Izon AFC for automated exosome and extracellular vesicle isolation (approximately 1 hour per sample). Need help? Message us for sample preparation and column storage guidelines. https://lnkd.in/gr583M5s Let's revolutionize exosome research together! #exosome #exosomeisolation #IZON #NUS #research #biotechnology #lifescience #innovation #evisolation #extracellularvesicles #translationalmedicine #bioscience #benchtobed #drugdelivery #nanomedicine