FROM: NNAMUDI MOKWUNYE, FOUNDER/CEO Welcome to HyperVention, the platform that personalizes drug schedules for hypertensive patients. "HyperVention" is a portmanteau of the words "hypertension" and "intervention". As 1 in 2 adult Americans is hypertensive, and hypertension remains the world's leading preventable cause of premature death, the disease likely affects you--or someone you know, or someone they know. HYPERVENTION IS PERSONAL My birth father died of a stroke in his sleep. He was hypertensive. Two years ago, I suffered a hypertensive crisis--meaning my blood pressure spiked and sustained at 222/121. If you, or someone you know, suffer from hypertension, you understand that, with those numbers, I am lucky to be alive--to have not suffered an aneurysm, stroke, or heart attack. However, I did suffer residual effects to my speech, balance, and overall electricals. They've gotten way better, but, for 18 months, I could not adequately execute the complex mental and physical functions I had done for over 20 years as a technology entrepreneur, strategy consultant, and fitness enthusiast. So, when my doctors prescribed my drugs to be taken at 9am and my blood pressure was still spiking at 11pm, I sensed that misaligned scheduling was the issue. So I took my blood pressure readings 30 times a day to generate enough data to identify spikes over daily 18 hours. Then I shifted my drug schedule to 9am, 3pm, and 9pm to cover 24 hours. Eventually, my blood pressure reduced to 114/73, leveled at 124/74, and just the other day was at 110/80. In hindsight, I realized I had created an effective system. While researching, I saw little done in the space of drug scheduling for hypertensive patients. So I patented my system and started a technology company to do for others what I had done for myself. THE PROBLEM The problem is that current, generic, drug scheduling methods do not target blood pressure spikes but expose hypertensive patients to severe outcomes such as aneurysms, strokes, heart attacks. We call these spikes "BP hotspots" and believe they can be muted and even eliminated. THE SOLUTION We are building HyperVention, a software platform that uses AI to personalize drug schedules for hypertensive patients. Our system is patent-pending and, if successful, we could move the needle in hypertension management, to the right, for the second time in 50 years. Join us in this journey! - tell your friends and family about HyperVention; - share this message with your network; - donate or invest, if you can; - write about why you think HyperVention could or could not work; - reach out if you'd like to work with or for us (we're hiring!) In the words of Tom Frieden (former CDC director), "Breakthrough drugs…are exciting, but the biggest health breakthrough of 2024 would be getting 100 million more people treated effectively for hypertension, the world’s leading killer." We're HyperVention. You're HyperVention. DONATE. INVEST. MOVE THE NEEDLE.
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Effectiveness of diagnosis and treatment based on movement system impairment in individuals with cervical pain: A randomized controlled trial Effectiveness of Movement System Impairment Model in Treating Neck Pain: Clinical Trial Results Background Movement System Impairment (MSI) classification and treatment effectively diagnose and treat individuals with neck pain. Current guidelines lack movement-specific mechanical diagnosis for neck pain management. Purpose This study aimed to investigate the effectiveness of the movement system impairment model among neck pain individuals. Methods The study was a randomized controlled trial with 82 participants screened, and 60 individuals meeting the criteria were randomized into experimental and control groups. Both groups received treatment and were assessed for pain intensity, cervical range of motion, muscle strength, endurance, and disability. Results After 10 treatment sessions over three weeks, both groups showed significant improvements in pain intensity, range of motion, muscle strength, endurance, and disability. The experimental group (MSI) demonstrated greater clinical benefits than the control group. Conclusion The movement system impairment model effectively diagnosed and treated neck pain in individuals with mobility deficits. Further research is needed to establish its long-term effects. Value in Clinical Practice Clinical trials are crucial for developing safe treatments. Our AI-driven platform, DocSym, consolidates standards, protocols, and research into an easily accessible knowledge base. Streamlining operations is essential in today’s healthcare environment, and our mobile apps support scheduling, monitoring treatments, and telemedicine to enhance workflows and improve patient outcomes. Learn more at aidevmd.com. https://lnkd.in/gc52CDDQ #ClinicalTrials #AIinHealthcare #MedicalAI #HealthTech #DigitalHealth #PatientCareAI #AIResearch #MedicalInnovation #BioTech #AIforGood #HealthcareData #AIinMedicine #PharmaAI #ClinicalData #HealthAI #AIHealthSolutions #PrecisionMedicine #AIandHealth #ClinicalAnalytics #AIDiagnostics
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Earlier this week, our very own Chief Medical Officer and Founder, Dr Martin Carlsson, joined a webinar hosted by Health Tech World focused on “weight management innovations for long lasting change”. Joining Dr Martin on the panel was Simon Pickup of Sweatcoin and Neel Gupta of Oviva. The discussion focused on how digital tools are revolutionising the weight loss industry and driving long-term solutions. Key areas of discussion included: 🌍The Global Health Crisis: Impact and challenges of the obesity epidemic 🤳Digital Revolution in Obesity Care: Leveraging technology for transformative treatment 🏫The Role of Education and Prevention: Fostering behavioural change Obesity is a global issue and the biggest health challenge of our time. It leads to numerous consequences including physical suffering, limited mobility, guilt, shame, and a host of other diseases such as diabetes, cardiovascular disease, infertility, multiple forms of cancer, fatty liver disease, sleep apnea, chronic pain, and mental health issues. By treating obesity, we can address and potentially eliminate many of these associated health problems. But addressing obesity requires the involvement of both healthcare systems and society as a whole. Effective obesity treatment necessitates personalised approaches, as one size does not fit all. Personalised treatments should take into account individual lifestyles and offer various different medications to achieve the most effective outcomes. Digital platforms like Yazen, which offers remote, 24/7 on-demand support, have shown that it is possible to achieve sustainable weight loss and offer hopeful changes for the future. Head to Yazen.co.uk to watch the full replay and post your comments below 👇 Let's drive positive change in obesity care together. #Yazen #YazenHealth #DigitalHealth #Innovation #ObesityTreatment #WeightManagement
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Efficacy and safety of eliapixant in endometriosis-associated pelvic pain: the randomized, placebo-controlled phase 2b SCHUMANN study Efficacy and Safety of Eliapixant in Endometriosis-Associated Pelvic Pain: The SCHUMANN Study Published in BMC Women’s Health, June 19, 2024 Background: The SCHUMANN study assessed the effectiveness and safety of eliapixant in treating endometriosis-associated pelvic pain (EAPP). Methods: This was a phase 2b study involving women with surgically diagnosed endometriosis and EAPP. Participants were randomly assigned to receive eliapixant at different doses or a placebo for 12 weeks. The primary goal was to measure the change in worst EAPP from baseline to the end of the study. Results: The study was terminated early due to safety concerns, with fewer participants completing the study than planned. No significant differences in EAPP reduction were found between the treatment groups, and the elagolix 150 mg group showed better pain reduction. While eliapixant was generally well tolerated, one participant receiving the highest dose experienced drug-induced liver injury, leading to a reassessment of the benefit-risk ratio for the study. Conclusions: The study did not achieve its primary objective, and the benefit-risk ratio was no longer considered positive due to safety concerns. Clinical trial registration: ClinicalTrials.gov identifier NCT04614246. Practical Solutions: Clinical trials are essential for developing safe treatments. Our AI-driven platform, DocSym, consolidates clinical standards and research for easy access by clinicians. Additionally, our mobile apps support scheduling, treatment monitoring, and telemedicine, streamlining operations and expanding digital services for patient care. Value: By leveraging AI, clinics can improve workflows, enhance patient outcomes, and reduce paper-based routines. Visit aidevmd.com to learn more about how we can help. https://lnkd.in/gdHTJwm2 #ClinicalTrials #AIinHealthcare #MedicalAI #HealthTech #DigitalHealth #PatientCareAI #AIResearch #MedicalInnovation #BioTech #AIforGood #HealthcareData #AIinMedicine #PharmaAI #ClinicalData #HealthAI #AIHealthSolutions #PrecisionMedicine #AIandHealth #ClinicalAnalytics #AIDiagnostics
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Smart Research Review: A randomized clinical trial and subgroup analysis to compare flexion-distraction with active exercise for chronic low back pain “...subjects randomly allocated to the flexion-distraction group had significantly greater relief from pain than those allocated to the exercise program.” “...subjects categorized as chronic, with moderate to severe symptoms, improved most with the flexion-distraction protocol.” “...a greater decrease in VAS among patients with radiculopathy should be expected for the flexion-distraction group where changes in disc pressure may be most important.” https://bit.ly/4ftF6EA
A randomized clinical trial and subgroup analysis to compare flexion-distraction with active exercise for chronic low back pain - PubMed
pubmed.ncbi.nlm.nih.gov
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Smart Research Review: The Nordic maintenance care program: maintenance care reduces the number of days with pain in acute episodes and increases the length of pain free periods for dysfunctional patients with recurrent and persistent low back pain "Manual treatments performed by chiropractors have been found to be effective in reducing pain intensity and disability for patients with LBP and are recommended in current practice guidelines." "There is now compelling evidence that stress the importance of careful the selection of patients for MC to include those who have recurrent or persistent low back pain." "Chiropractic Maintenance Care reduces the number of days of bothersome (activity-limiting) pain within each new LBP episode among patients classified as dysfunctional (by the MPI-S instrument). MC stabilizes the clinical course and increases the number of pain-free weeks between episodes." https://bit.ly/4cN1o1w
The Nordic maintenance care program: maintenance care reduces the number of days with pain in acute episodes and increases the length of pain free periods for dysfunctional patients with recurrent an…
chiromt.biomedcentral.com
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Smart Research Review: The Nordic maintenance care program: maintenance care reduces the number of days with pain in acute episodes and increases the length of pain free periods for dysfunctional patients with recurrent and persistent low back pain "Manual treatments performed by chiropractors have been found to be effective in reducing pain intensity and disability for patients with LBP and are recommended in current practice guidelines." "There is now compelling evidence that stress the importance of careful the selection of patients for MC to include those who have recurrent or persistent low back pain." "Chiropractic Maintenance Care reduces the number of days of bothersome (activity-limiting) pain within each new LBP episode among patients classified as dysfunctional (by the MPI-S instrument). MC stabilizes the clinical course and increases the number of pain-free weeks between episodes." https://bit.ly/3P3tPPL
The Nordic maintenance care program: maintenance care reduces the number of days with pain in acute episodes and increases the length of pain free periods for dysfunctional patients with recurrent an…
chiromt.biomedcentral.com
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MEDICAL DEVICES WEEKLY ROUND-UP ✏ 🔬 Neuronetics, Inc. Has agreed to merge with Greenbrook TMS Inc and will acquire treatment centres that use its mental health devices. Neuronetics provides Greenbrook with transcranial magnetic stimulation devices for major depressive disorder, which is typically used when other treatments haven't worked. The deal is expected to generate annual cost savings of at least $15 million. 💊 Baxter International Inc. has agreed to sell its Vanitive Kidney care business to The Carlyle Group. The sale is expected to generate a growth of of 4% to 5% once completed and will allow Baxter to become a more "focused and efficient company." 💉 Otsuka Precision Health, Inc. (OPH) has launched its first product in the digital health subsidiary! The app based treatment for major depressive disorder, named Rejoyn, is intended to be used alongside medication to allow patients to target neural connections needed to process emotions. During clinical trial phase, patients who used Rejoyn saw a significant improvement on the Montgomery-Åsberg Depression Rating Scale. 💰 President Biden has pledged to award $150M in funding to 8 organisations developing technologies to help surgeons remove cancerous tumours. The award is a part of the White House’s Cancer Moonshot initiative, which aims to reduce cancer related deaths by half by 2047. #medicaldevices #usmedicaldevices #medicaldevicemanufacturing #usmedicaldevicemanufacturing
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We're excited to share our latest publication, "Lightening the Load: Generative AI to Mitigate the Burden of the New Era of Obesity Medical Therapy." 🌐 This paper explores how AI-powered solutions can streamline the management of GLP-1/dual receptor agonist medications, easing the strain on healthcare systems while improving patient outcomes. A must-read for healthcare professionals, AI enthusiasts, and policymakers aiming to shape the future of medical care. 📘 Access the full text here: https://lnkd.in/esAB3x4T #AIinHealthcare #ObesityTherapy #HealthTechInnovation
Lightening the Load: Generative AI to Mitigate the Burden of the New Era of Obesity Medical Therapy
diabetes.jmir.org
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Smart Research Review: A randomized clinical trial and subgroup analysis to compare flexion-distraction with active exercise for chronic low back pain “...subjects randomly allocated to the flexion-distraction group had significantly greater relief from pain than those allocated to the exercise program.” “...subjects categorized as chronic, with moderate to severe symptoms, improved most with the flexion-distraction protocol.” “...a greater decrease in VAS among patients with radiculopathy should be expected for the flexion-distraction group where changes in disc pressure may be most important.” https://bit.ly/3UoJQmO
A randomized clinical trial and subgroup analysis to compare flexion-distraction with active exercise for chronic low back pain - PubMed
pubmed.ncbi.nlm.nih.gov
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Spinal cord stimulation combined with exercise in patients diagnosed with persistent spinal pain syndrome. Study protocol for a randomized control trial Spinal Cord Stimulation and Exercise for Persistent Spinal Pain Syndrome Study Overview This study investigates how spinal cord stimulation (SCS) combined with exercise can help patients with persistent spinal pain syndrome (PSPS-T2). The goal is to see if this combination can reduce pain, improve quality of life, and decrease disability. Study Design We are conducting a double-blind randomized clinical trial. This means participants will be randomly assigned to either the treatment group or a control group without knowing which group they are in. The study follows strict guidelines to ensure reliability and has been registered at Clinicaltrial.gov. Participants We aim to recruit 52 participants, accounting for a possible 30% dropout rate. Each participant will attend two sessions per week for 8 weeks, totaling 16 sessions. Each session will last 60 minutes and will focus on safe exercises to avoid complications. Expected Outcomes The main outcomes we will measure include: Functionality Satisfaction Strength Psychosocial factors Quality of life Pain perception Importance of Clinical Trials Clinical trials are essential for developing safe and effective treatments. They help translate research findings into everyday medical practice. Practical Solutions for Healthcare Our AI-driven platform, DocSym, consolidates clinical standards and research into an easy-to-use resource for healthcare providers. This helps streamline operations and improve patient care. Enhancing Patient Care Our mobile apps assist with scheduling, treatment monitoring, and telemedicine, making it easier for clinics to manage patient care and expand their services digitally. By using AI, clinics can improve workflows, enhance patient outcomes, and reduce paperwork. Learn more about how we can assist at aidevmd.com. https://lnkd.in/gKpMKnjN #ClinicalTrials #AIinHealthcare #MedicalAI #HealthTech #DigitalHealth #PatientCareAI #AIResearch #MedicalInnovation #BioTech #AIforGood #HealthcareData #AIinMedicine #PharmaAI #ClinicalData #HealthAI #AIHealthSolutions #PrecisionMedicine #AIandHealth #ClinicalAnalytics #AIDiagnostics
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Chief Product Officer I Focused on solving complex challenges in Life Sciences leveraging Big Data & AI
4moInsightful, my initial assumptions was that drugs with longer half lives can give 24hour coverage and reduce the impact of spikes. It would be great to know more about what you are doing