🔬 New Research on cardiac troponins 🔬 The impact of commonly used anticoagulants such as sodium citrate, heparin and EDTA, on the integrity of the ITC-complex in the samples remains unclear. 🧑🔬 To address this, Hytest scientists have conducted extensive studies – with the results compiled in our latest article published in the International Journal of Molecular Sciences. ➡️ Read more and stay ahead of the curve in cardiac diagnostics: https://lnkd.in/dkDWkCnN #IVD #CardiacDiagnostics #Troponins #ClinicalLabs #antibody
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This is truly exciting! Sure, this advancement promises new possibilities for treating neurological disorders with precision. The precision and adaptability of engineered T cells are opening doors to revolutionize treatments for complex brain disorders. Such innovations could significantly improve patient outcomes and reduce side effects by targeting therapies exactly where they're needed. 🌟 #NextGenMedicine #NeuroTherapeutics #QuantumAILab
An engineered T cell (center) is designed to deliver therapies to the brain. This T cell displays orange synthetic receptors on its surface, which recognize components of extracellular matrix fibers that are only found in the brain. Within the cell, downstream signaling pathways are programmed to initiate transcription and release a therapeutic payload—shown as light blue protein secretions. Learn more in this week's issue of Science: https://scim.ag/4ip9Tnw
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The latest issue of Science Magazine highlights recent advancements in T cell engineering and their role in delivering therapies to the brain. If you're intrigued by the pivotal role of T cells in health and disease, check out our journal Critical Reviews™ in Immunology! Our latest article, "The Value of Systemic Immune-Inflammation Index and T Cell Subsets in the Severity and Prognosis of Sepsis", dives into the clinical importance of T cells in sepsis. Read it here: https://lnkd.in/eXcsrwSq #TCells #Immunology #CRI #OpenAccess #AcademicResearch
An engineered T cell (center) is designed to deliver therapies to the brain. This T cell displays orange synthetic receptors on its surface, which recognize components of extracellular matrix fibers that are only found in the brain. Within the cell, downstream signaling pathways are programmed to initiate transcription and release a therapeutic payload—shown as light blue protein secretions. Learn more in this week's issue of Science: https://scim.ag/4ip9Tnw
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An engineered T cell (center) is designed to deliver therapies to the brain. This T cell displays orange synthetic receptors on its surface, which recognize components of extracellular matrix fibers that are only found in the brain. Within the cell, downstream signaling pathways are programmed to initiate transcription and release a therapeutic payload—shown as light blue protein secretions. Learn more in this week's issue of Science: https://scim.ag/4ip9Tnw
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Bravo to Wendell Lim, PhD, and team for making the cover of Science Magazine! The team armed immune cells with “molecular GPS” to find and treat brain cancer, MS and type I diabetes. Clinical trials could begin as soon as 2025. Molecular Zip Code Draws Killer T Cells to Brain Tumors: https://lnkd.in/gBcfVGQv Engineered Immune Cells May Be Able to Tame Inflammation: https://lnkd.in/gaHdfwHM Advanced Research Projects Agency for Health (ARPA-H) National Cancer Institute (NCI)
An engineered T cell (center) is designed to deliver therapies to the brain. This T cell displays orange synthetic receptors on its surface, which recognize components of extracellular matrix fibers that are only found in the brain. Within the cell, downstream signaling pathways are programmed to initiate transcription and release a therapeutic payload—shown as light blue protein secretions. Learn more in this week's issue of Science: https://scim.ag/4ip9Tnw
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Expert en Biologie Moléculaire et en Communication | Analyste Senior en Génomique et Séquençage ADN | Formateur et Conférencier
🚀 Medicine is being revolutionized! Engineered cells are now custom-designed to target disease with laser-like precision 🎯. One breakthrough reprogrammed T cells to neutralize autoimmune attacks and calm inflammation, while another created cells that hunt down brain cancer, sparing healthy tissues. These therapies are the future of medicine 🩺. #Biotech #Innovation #FutureOfMedicine
An engineered T cell (center) is designed to deliver therapies to the brain. This T cell displays orange synthetic receptors on its surface, which recognize components of extracellular matrix fibers that are only found in the brain. Within the cell, downstream signaling pathways are programmed to initiate transcription and release a therapeutic payload—shown as light blue protein secretions. Learn more in this week's issue of Science: https://scim.ag/4ip9Tnw
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Product Specialist at PT. Biogen Scientific | Molecular Biologist | Member of Royal Society of Biology (MRSB) | Member of Asian Federation of Biotechnology Indonesia (AFOB-ID)
CAR-T Cell offers a potentially curative option for patients refractory to standard anti-cancer treatments. CAR-T cell therapy's success in acute lymphoblastic leukaemia (ALL) and specific types of B cell lymphoma led to rapid regulatory approvals of CD19-directed CAR-T cells. Hopefully, this breakthrough research could be conducted and escalated broadly in rapid as this therapeutic medicine would foster the medical treatment of cancer therapy.
An engineered T cell (center) is designed to deliver therapies to the brain. This T cell displays orange synthetic receptors on its surface, which recognize components of extracellular matrix fibers that are only found in the brain. Within the cell, downstream signaling pathways are programmed to initiate transcription and release a therapeutic payload—shown as light blue protein secretions. Learn more in this week's issue of Science: https://scim.ag/4ip9Tnw
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🧬 Organoids are opening new horizons in scientific research. They mimic the structure and function of real organs, offering groundbreaking insights into development, drug responses, and disease mechanisms. 🤓 As Multi Channel Systems GmbH, we are working closely with our partners as pioneers in this area. Mesh MEA is our latest solution in organoid research which allows true-to-life recordings from inside an organoid without compromising its structure. 👨🏽🔬 Our partner NMI Naturwissenschaftliches und Medizinisches Institut has created a poster named "An innovative approach for conducting 3D electrophysiological recordings within intact organoids" which is based on the Mesh MEA technology and was an initiative by Peter Jones and his collegues. You can find the full poster here: https://lnkd.in/e-kY6qSZ If you want to learn more about our Mesh MEAs, please have a look here: https://lnkd.in/eTvF6P_C #MultiChannelSystems #NMI #poster #organoid #organoidresearch
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Medical Affairs Strategy; Director of Medical Sciences, Rare Primary Immunodeficiencies and HAE; Rare Genetic Neurological and Mitochondrial disorders
Have designed, brain-targeted therapeutics finally have arrived? Molecular-targeted therapy with lower drug dosing holds potential for treating many brain diseases. #BBB #engineeredTcell #immunology #braintherapies #cancer #raredisease
An engineered T cell (center) is designed to deliver therapies to the brain. This T cell displays orange synthetic receptors on its surface, which recognize components of extracellular matrix fibers that are only found in the brain. Within the cell, downstream signaling pathways are programmed to initiate transcription and release a therapeutic payload—shown as light blue protein secretions. Learn more in this week's issue of Science: https://scim.ag/4ip9Tnw
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Revealing presenilins as hub proteins regulating extracellular vesicle secretion: Inger Lauritzen, Frédéric Checler at IPMC CNRS - University Nice Sophia Antipolis and collaborators investigated the role of presenilins (PSEN1 and PSEN2), previously linked to autophagy regulation, in the secretion of small extracellular vesicles of endocytic origin. In wild-type cells, stimuli promoting multivesicular endosome formation and sEV secretion enriched in canonical exosomal proteins elicited a robust response. In contrast, PSEN-deficient cells showed minimal responsiveness to these stimuli https://lnkd.in/eMsSpUh4 Reintroducing either PSEN1 or the functional PSEN1delta9 mutant in PSEN-deficient cells restored most sEV secretion, while PSEN1 deletion alone largely recapitulated the effects of total PSEN invalidation. Their findings highlight PSENs, particularly PSEN1, as pivotal regulators balancing endosomal and autophagic degradation with sEV secretion. More broadly, they underscore the intricate interplay between endocytic and autophagic pathways and their complementary roles in regulating sEV secretion. An article co-authored by Anaïs Bini, Anaïs Bécot, Anne-Sophie Gay, Céline Badot, Sophie Pagnotta and MOUNIA CHAMI #extracellularvesicles #exosomes #autophagy #CD63 #Vesiculab
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The final piece of my PhD with Irit Sagi is now out in the Journal of Proteome Research! This a was joint work with Dr. Veronica Ghini at the University of Florence, and co-authored also with Inna Solomonov. We integrated #proteomics w/ tissue and fecal #metabolomics data over the course of chronic and acute #colitis. We found that colitis is characterized by an anaerobic switch, and most importantly that the very early, pre-symptomatic state in colitis has its unique metabolic signature, highlighting the prognostic potential of metabolic profiling. https://lnkd.in/dVisrrTf
