Institute for Network Medicine (iNetMed)’s Post

Turns out, #cancer cells use the same strategy when they don't have what it takes: #Beg, #Borrow or #Steal! This is how biological networks provide insights from information at UC San Diego Institute for Network Medicine (iNetMed)! Congratulations, Saptarshi Sinha. Thanks to our long-term colleagues at University of Michigan Michigan Medicine. #CancerResearch; #Metastasis; #TumorBiology; #BoneMarrowNiche #PrecisionMedicine; #SystemsBiology; #Oncology; #Innovation; #MolecularBiology; #DrugResistance; #CancerRelapse; #BiomedicalResearch; #TranslationalResearch; #LifeSciences

Ever wondered how tumor cells survive the hostile environment of the bloodstream and successfully colonize distant organs under therapy pressure? 🧐 🩸🔬 🧫 Our latest article, in #NatureCancer Springer Nature, sheds light on the crucial role of compensatory mechanisms involving neuregulin 1-HER3 and FGFR1 in the survival of circulating tumor cells (CTCs). We demonstrate how these pathways can be exploited to establish long-term CTC-derived organoids (CDOs) in vitro. The discovery of this form of CTC plasticity and the development of this new CDO platform have significant implications for understanding and potentially targeting metastatic disease. Big thanks to all co-authors, institutions, funding supporters, reviewers, editors, patients and their families. More to come! Looking forward to hearing your feedback and potential interest in collaborating. Read the full article here: https://lnkd.in/dV2F_93K #liquidbiopsy, #Cancer, #Metastasis, #CirculatingTumorCells, #BreastCancer, Nature Portfolio, DKFZ German Cancer Research Center, HI-STEM gGmbH: The Heidelberg Institute for Stem Cell Technology and Experimental Medicine, NCT Heidelberg - National Center for Tumor Diseases (NCT) Heidelberg, University of Heidelberg, Universitätsklinikum Hamburg Eppendorf , Technical University of Munich, Miltenyi Biotec

🧬 New Hypothesis on Cancer Mechanisms! 🧬 In "Interactions between the DNA Damage Response and the Telomere Complex in Carcinogenesis," Antonio Torres-Montaner explores how telomere damage and DNA repair dysfunction contribute to the early stages of cancer development. 👉 This hypothesis delves into the role of telomere maintenance in transformation and the survival of cancer stem cells, offering new insights into the progression of carcinogenesis. 🔎 Discover more about this fascinating intersection of DNA damage and cancer stem cells in Current Issues in Molecular Biology: https://lnkd.in/eW_6i9Va #CancerResearch #Telomeres #DNARepair #StemCells #Carcinogenesis

Advancements in medical research are bringing new hope to treat deadly diseases. For example, Natural Killer (NK) cells are great allies in the fight against cancer. NK cells are naturally occurring white blood cells that fight infections and other intruders, including precancerous cells. Jeffrey Miller, MD, Deputy Director at the Masonic Cancer Center, University of Minnesota and his team are successfully using NK cell therapy to treat one of the most deadly forms of brain cancer, glioblastoma. As AI converges with Biotech, we will see additional discoveries that promise to cure the deadliest diseases afflicting humanity. This is one of the most exciting developments in exponential technologies. #ai #biotech #convergence https://lnkd.in/gz7ZJwxJ

I am truly excited to see the furthering of the science and, now, a therapy in testing developed by Jinming Gao and his medical collaborator and co-founder of OncoNano Medicine, Inc., Baran Sumer M.D., F.A.C.S! The therapy was developed at UT Southwestern Medical Center and focuses on activating the STING pathway to fight cancer. Dr. Gao's research team created this novel therapy by embedding cGAMP in PC7A nanoparticles, enhancing STING activation for an extended period. This approach showed significant success in shrinking tumors and preventing metastasis and relapse in mouse models of various cancers. The nanoparticles specifically act on type 1 conventional dendritic cells, which are crucial for priming T cells to fight tumors. A Phase 2A non-randomized, open-label study, ILLUMINATE, is now targeted to start its enrolment in mid-2024. It will be exciting to see the first readouts from this promising trial! #clinicaltrials #oncology https://lnkd.in/gPk4npYm

Do Stem-Cell Transplants Increase Cancer Risk? New Findings from Long-Term Recipients 🧬 A recent study sheds light on the long-term impacts of stem-cell transplants, particularly for blood cancer patients who received their transplants over 40 years ago. Surprisingly, these recipients do not exhibit high rates of cancer-causing mutations, suggesting that stem-cell transplants may not inherently increase cancer risk in the long run. This research offers valuable insights into the safety and longevity of stem-cell treatments, an encouraging development for both patients and healthcare providers in the field of regenerative medicine. #StemCells #CancerResearch #Transplant https://lnkd.in/ds9tQuJx

🔍 New Insights Reveal Bone’s Crucial Role in Cancer Metastasis 🦴 Recent studies have unveiled a groundbreaking understanding of how bones are not just passive sites for cancer spread but are actively involved in the metastatic process. By altering their mineral structure and the surrounding marrow environment, bones can condition other body sites, facilitating the spread of cancer cells. Key Takeaways: - Bone Microenvironment: The bone marrow niche disrupts cellular communities, supporting metastatic growth. - Innovative Technologies: Advanced imaging and molecular biology reveal how cancer cells manipulate bone environments to thrive. - Targeted Therapies: Focusing on bone niche interactions could lead to effective treatments that curb metastasis. This research opens new avenues for intervention strategies that could restore the protective functions of bone marrow and improve patient outcomes. Stay informed on this vital development in cancer research! Click on the link to learn more! #BoneHealth #CancerResearch #InnovativeTherapies #Metastasis #Oncology #Publications #MarketAccess #MarketAccessToday

📊 AI-Powered Blood Test Revolutionizes Early Cancer Detection Edinburgh University scientists combine laser analysis with artificial intelligence, achieving 98% accuracy in detecting stage 1a breast cancer. 🔬 Their innovative approach uses Raman spectroscopy to analyze blood plasma, detecting cellular changes before symptoms appear. 💡 The technology surpasses existing methods by identifying cancer at its earliest stage, when treatment effectiveness peaks. 🏥 This non-invasive alternative to traditional screening shows 90% accuracy in distinguishing between breast cancer subtypes. 🌐 Multi-institutional collaboration aims to expand testing for various cancer types. 📱 Follow Karmactive for cutting-edge medical breakthroughs Click the link to explore this scientific advancement. https://lnkd.in/dihF2gUa #MedicalInnovation #CancerResearch #HealthTech #AIinHealthcare #MedicalScience

Immune cells are a very important area of study for cancer researchers because understanding how they do (or do not) function against cancer is critical for developing therapies. Wistar’s Qing Chen, M.D., Ph.D., has confirmed that measuring the gene Tmem119 will allow her lab to better understand how microglia function in cases of brain metastasis. “This is an exciting confirmation that we can indeed identify and quantify activated microglia in cases of metastasis to the brain,” said Dr. Chen. “It’s a crucial first step in working to understand how these immune cells interact with cancer, and we look forward to future mechanistic studies of these cases.” Read our full story here: https://lnkd.in/eEtWxFpd #canccer #research #biomarker #metastasis #braincancer

https://lnkd.in/dxfNF2Gf   Article title: Atypical Fibroadenoma Presentation of a Case   Author(s): Juana Teresa Santiago Pérez; José Miguel González Barcena; Yuranis Gárciga Martin; Yahumara Suarez Morales   Journal: Global Journal of Cancer Therapy   Journal ISSN: 2581-5407   Abstract: Fibroadenoma is the most common benign breast lesion in women below 30 years. They are usually lesions associated with early ages of life [1] Its most common form of presentation is a hard, painless and mobile mass that can have a large size. The diagnosis is made regularly with imaging tests, with ultrasound being the method of choice in young patients, although mammography and nuclear magnetic resonance imaging are diagnostic tools, in women over 35 years. From the histological point of view it is a mixed tumor in which there is proliferation of the intralobular stromal connective tissue, and a cluster multiplication of the ducts.   #Giantfibroadenoma #Breast #Fillodestumor   #Oncology #CancerImmunology #MolecularAndCellBiologyOfCancer #Oncogenes #Peertechz #PeertechzPublications #Carcinogenesis #RadiationBiology #MolecularPathology #HormonesAndCancer #ViralOncology #Angiogenesis #Metastasis #CellularMicroenvironment #GynecologicalCancer #LungCancer #ObstetricsAndGynecology #CancerResearchAndMolecularBiology #CellBiology #CancerGenesAndGenomics #CellCycle #CellDeath #Senescence #DNADamageAndCellularStressResponses #ModelOrganisms #SignalingAndRegulation #GenesChromosomesAndCancer #CancerGeneTherapy #PediatricBloodAndCancer #CancerResearchAndTreatment #DiagnosePrecancerousLesionsAndEarlyStageCancers #MolecularChangesLeadingToEachTypeOfCancer #MolecularChangesAffectTumourGrowthRateAndInvasiveness #DifferenceBetweenCancerCellAndNormalCell #BloodBoneMarrow #BreastDisease #GenitourinaryDisease #GynecologicOncology #HeadAndNeckDisease #HepatobiliaryTract #IntegratedMedicine #LungDisease #Carcinogenesis #CancerCellBiology #CancerGenetics #InfectiousCausesOfCancer #TumorImmunology #EarlyDetectionAndDiagnosis #ExperimentalCancerTherapeutics #IdentificationOfMolecularTargets #TargetsForChemoprevention #NewModels #CancerChemistry #DrugDiscovery #MolecularAndCellularPharmacology #MolecularClassificationOfTumors #BioinformaticsAndComputationalMolecularBiology #GeneticAndMolecularCausesOfCellularTransformationAndCancer #MolecularBasisOfPotentialTherapies #BiologyAndBiochemistryOfCancer #AntiCancerDrugs #AntiCancerAgents #CancerCausesAndControl #CancerEpidemiology #BiomarkersAndPrevention #ExperimentalOncology #ClinicalOncology #MedicalOncology #PediatricOncology #RadiationOncology #SurgicalOncology #TranslationalOncology #NeuroOncology #Pathology #CancerResearch #DiagnosisAndTreatment #ClinicalCancerResearch #CancerMicroenvironment #CancerStemCells