📬Article of the Week📜 Suggested by the #BPDCN International Registry❗️-Astghik Voskanyan 🖍 #Tagraxofusp for blastic plasmacytoid dendritic cell neoplasm Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive leukemia primarily affecting older men, with involvement often in the skin, bone marrow, lymph nodes, and #CNS. Due to its rarity and unique management needs, patients should ideally be referred to specialized cancer centers with clinical trials and expertise in BPDCN. Comprehensive staging and expert hematopathology review are essential. BPDCN universally expresses #CD123, the IL-3 receptor, a key therapeutic target. Treatment options include tagraxofusp, a CD123-targeting IL3-diphtheria toxin conjugate, or conventional chemotherapy. Allogeneic #HSCT in first remission (CR1) is recommended if feasible. Treatment choice depends on disease features, patient health, goals, and available center expertise. Close monitoring for toxicities, especially capillary leak syndrome (CLS), is crucial when using tagraxofusp, particularly in the first cycle. 🔖Authors:Marlise Luskin ,Andrew Lane, MD, PhD 📜 https://lnkd.in/dsjNx6X3 #Tagraxofusp, #cancer, #immuneoncology, #HSCT
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*How to Choose Among Similar CAR-T Therapies?* Currently, there are multiple CAR-T products targeting the same antigen available on the market, which can make it difficult for patients to decide which one to choose. Experts recommend selecting a therapy based on the treatment target. It is generally advisable to prioritize approved products, as they have been validated, providing better assurance of safety and efficacy. For example, CD19-targeting CAR-T products are typically preferred over CD22-targeting ones, and BCMA-targeting therapies are favored over GPRC5D-targeting ones. Additionally, it’s important to consider the origin of the CAR-T cells (such as human-derived vs. mouse-derived) and the costimulatory signals used (e.g., 4-1BB vs. CD28). Different conditions may also influence the choice; for instance, lymphoma patients may be more suitable for CD28, while those with acute leukemia might benefit more from 4-1BB. In the end, patients are advised to make an informed decision based on their medical history and the guidance of their doctors. 🎉🎉To assess whether the condition is suitable for CAR-T therapy, you can submit pathology reports, treatment history, and discharge summaries to the Medical Department of Advanced Medicine in China for preliminary evaluation! WhatsApp: Https://wa.me/+8613717959070 Email: doctor.huang@globecancer.com #cart #carttherapy #CAR_T #leukemia #lymphoma #cancer #tumor #bloodcancer
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#thyroidcancer #cancerresearch #oncology https://lnkd.in/g6-_Da_8 Background The prognostic significance of lymph node metastasis (LNM) in papillary #thyroid carcinoma (PTC) remains controversial. Notably, there is evidence suggesting an association between #tissue #stiffness and the aggressiveness of the disease. We therefore aimed to explore the effect of tissue stiffness on LNM-related invasiveness in PTC patients.
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#lungcancer #cancerresearch #oncology #cancertreatment Challenges in early-stage NSCLC harboring EGFR mutation. ACT, adjuvant chemotherapy; MRD, minimal residual disease. Treatment with 3 years of adjuvant #osimertinib is considered a new standard in patients with completely resected stage I to IIIA NSCLC harboring a common sensitizing #EGFR #mutation. This therapeutic approach significantly prolonged the disease-free survival and the overall survival versus placebo and revealed a significant role in preventing the occurrence of brain metastases. However, many unanswered questions remain, including the optimal duration of this therapy, whether all patients benefit from adjuvant osimertinib, and the role of adjuvant chemotherapy in this population. Indeed, there is a renewed interest in neoadjuvant strategies with targeted therapies in resectable NSCLC harboring oncogenic drivers
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Prostate cancer cases are expected to double worldwide between 2020 and 2040, according to the Lancet Commission on prostate cancer. This surge in cases cannot be prevented by lifestyle changes or public health interventions alone, according to the commission. However, one important way to mitigate the harm caused by rising case numbers is to urgently set up systems for earlier diagnosis, especially in low- and middle-income countries. The American Urological Association (AUA) provides guidelines for the early detection of #prostatecancer with an emphasis on prostate-specific antigen (PSA)-based screening, considerations for initial and repeat biopsy, and biopsy technique with the goal of identifying clinically significant prostate cancer. https://lnkd.in/ew9mVTbi
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Principal Scientist | Immuno-oncology | Cancer Vaccines and Immunotherapy | Drug Discovery | Project Leader | R&D
Prognostic Significance of Tertiary Lymphoid Structures and Tumour-Infiltrating Lymphocytes in Clear Cell Renal Carcinoma A study investigated the characteristics and clinical significance of tertiary lymphoid structures (TLSs) and tumour-infiltrating lymphocytes (TILs) in clear cell renal cell carcinoma (ccRCC) across 1,286 patients. TLSs were present in 16% of tumours and associated with improved survival and therapy response, particularly when mature and dense. Conversely, high infiltration of scattered TILs predicted poor prognosis. The study highlighted the importance of immune infiltration patterns, showing that mature TLSs correlate with decreased relapse and death risks, whereas high TILs indicate worse outcomes, revealing complex immune dynamics in ccRCC. The link to the original article is in the comments. If you found this post valuable, give it a like and share it with your network! 😃 #CancerResearch #Immunotherapy #RenalCellCarcinoma #TertiaryLymphoidStructures #TumorInfiltratingLymphocytes #TLSs #TILs #ImmunoOncology Be at the forefront of cancer immunotherapy breakthroughs! 🔬 Subscribe for FREE to my monthly Newsletter for a dose of knowledge and the latest advancements: https://lnkd.in/ec5sV-iP 📧 #ImmunotherapyFrontiers #StayInformed #ImmunotherapyExploration #DontMissOut"
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https://lnkd.in/g_3hMi8N Article title: Survival benefits and safety of chemotherapy regimens for pancreatic cancer: An umbrella review of meta-analyses of randomized controlled trials Author(s): Aditi Kharat; Chia Jie Tan; Manit Saeteaw; Anindit Chhibber; Joseph Biskupiak; Sajesh K Veettil; Nathorn Chaiyakunapruk Journal: Annals of Pancreatic Disorders and Treatment Journal ISSN: 2692-4730 Abstract: Introduction: Several meta-analyses have reported the survival benefits and safety issues of chemotherapy regimens for pancreatic cancer (PC). The aim was to perform an umbrella review to summarize the existing evidence from meta-analyses of randomized controlled trials (RCTs). Methods: EMBASE, PubMed, Cochrane database of systematic reviews, and Epistemonikos were searched from inception to October 31st, 2021.Methodological quality was assessed using the A Measurement Tool to Assess Systematic Reviews (AMSTAR-2). The quality of evidence was evaluated using GRADE criteria (Grading of Recommendations, Assessment, Development, and Evaluations). #PancreaticCancer #ChemotherapyRegimens #FOLFIRINOX #GemcitabineNabPaclitaxel #UmbrellaReview #Resected #AdvancedPancreaticCancer #AcutePancreatitis #AcutePancreatitisSymptoms #BiliaryDyskinesia #ChronicPancreatitis #GallBladderSymptoms #GallbladderDisease #GallstonePancreatitis #HereditaryPancreatitis #Peertechz #PeertechzPublications #OpenAccess #ScientificJournals #PeerReviewedJournals #OpenAccessPublishers #InflamedPancreas #PancreasAnatomy #PancreasPain #Pancreatectomy #PancreaticDisorder #PancreaticDuct #PancreaticEnzymeReplacementTherapy #Pancreatitis #PancreatitisSymptoms #ProtonTherapyPancreaticCancer #SwollenPancreas
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Director of Process Development/CMC and Regulatory Affairs/Global PD Steering Committee, Biotechnology R&D and Biopharmaceutical Manufacturing
Tertiary Lymphoid Structures (TLSs) and Tumor Infiltrating Lymphocytes (TILs) - Prognostic Significance
Principal Scientist | Immuno-oncology | Cancer Vaccines and Immunotherapy | Drug Discovery | Project Leader | R&D
Prognostic Significance of Tertiary Lymphoid Structures and Tumour-Infiltrating Lymphocytes in Clear Cell Renal Carcinoma A study investigated the characteristics and clinical significance of tertiary lymphoid structures (TLSs) and tumour-infiltrating lymphocytes (TILs) in clear cell renal cell carcinoma (ccRCC) across 1,286 patients. TLSs were present in 16% of tumours and associated with improved survival and therapy response, particularly when mature and dense. Conversely, high infiltration of scattered TILs predicted poor prognosis. The study highlighted the importance of immune infiltration patterns, showing that mature TLSs correlate with decreased relapse and death risks, whereas high TILs indicate worse outcomes, revealing complex immune dynamics in ccRCC. The link to the original article is in the comments. If you found this post valuable, give it a like and share it with your network! 😃 #CancerResearch #Immunotherapy #RenalCellCarcinoma #TertiaryLymphoidStructures #TumorInfiltratingLymphocytes #TLSs #TILs #ImmunoOncology Be at the forefront of cancer immunotherapy breakthroughs! 🔬 Subscribe for FREE to my monthly Newsletter for a dose of knowledge and the latest advancements: https://lnkd.in/ec5sV-iP 📧 #ImmunotherapyFrontiers #StayInformed #ImmunotherapyExploration #DontMissOut"
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1/6 🚨 Resin 90Y-TARE significantly improved outcomes in non-colorectal cancer liver metastases! Better PFS, TTP, and OS compared to mCRC 🩸 Explore the new findings in @JVIRmedia’s latest study on this targeted therapy for unresectable liver-dominant metastases! 🧵 👇 #VIR 2/6 Study Insights: 📌 1474 patients from RESiN registry 📌 481 treated for non-CRC liver metastases (m-nonCRC) Compared with: ✅ 497 for mCRC ✅ 496 for HCC #LiverMetastases #Oncology #InterventionalRadiology 3/6 Key Findings: 📊 Radiologic responses in 12 cancer types, mostly refractory to systemic therapies 📊 Superior outcomes in m-nonCRC vs. mCRC: 📈 Duration of response, PFS, TTP, OS all significantly better (p < 0.05) #CancerTreatment #Y90 #TARE #Radioembolization 4/6 Detailed Results: ✅ Metastatic neuroendocrine, sarcoma, ovarian, renal, prostate, and breast cancers showed superior outcomes ⚠️ Worse outcomes in metastatic lung, gastric, pancreatic, and esophageal cancers #MetastaticCancer #PrecisionMedicine #IR 5/6 📌 Conclusion: Resin 90Y-TARE is a promising treatment for refractory, non-CRC liver metastases, outperforming standard therapies. 🔗 Full study: https://lnkd.in/gJtxe7JZ #CancerResearch #MedicalInnovation #InterventionalOncology 6/6 What are your thoughts? @danbrownIO @RS_IntervRad @DanSzeMDPhD IRs using #AI will replace those who don’t! Save time, get smarter, & become AI enhanced! Be sure to subscribe our newsletter: https://lnkd.in/gRwAjsEf #VIR #iRad #LiverCancer @SIRspecialists @SIRRFS
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Oncology pharmacist | Community pharmacist | Article writer | Passionate about medical writing and searching | Interested in pharmacy administration and management.
Breast cancer 6 #Radiation_therapy Radiation therapy has a significant role in local disease control. Radiation therapy Is #not_necessarily for women 70 years of age and older with small, lymph node-negative, hormone receptor-positive (HR+) cancers. Radiation therapy is #beneficial in large tumors (greater to 5 cm) or if the tumor invades skin or chest wall and if there are positive lymph nodes. It can also be used as palliative therapy in advanced cases, such as a central nervous system (CNS) or bone metastasis. It can be delivered as external beam radiation, brachytherapy, or a combination of both. #breast_cancer #oncology #chemotherapy #drugs #pharmacy #pharmacist
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New!⛄️ #Cryoablation-induced #neutrophil Ca2+ elevation and NET formation exacerbate #immuneescape in #colorectalcancer #livermetastasis ------------------ Liver metastasis poses a significant barrier to effective immunotherapy in patients with colorectal cancer. Cryoablation has emerged as a vital supplementary therapeutic approach for these patients. However, its impact on the tumor microenvironment following the ablation of liver metastases remains unclear. Here Fan et al underscore the critical role of neutrophils and their NETs in immune escape following cryoablation. Targeting the CXCL2-CXCR2-Ca2+-PAD4 axis could enhance the therapeutic response to PD-1 antibodies, providing a potential strategy to improve treatment outcomes for colorectal cancer with liver metastases. Full text👇 https://lnkd.in/dWau6MP2 #Immunotherapy IFO - Istituto Nazionale Tumori Regina Elena - Istituto Dermatologico San Gallicano
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