Immuno Diagnostic Oy’s Post

Crémant and smiles to farewell my PhD student Candy L. Steffen Steffen! Good luck and all the best for your future. This event also marked the acceptance of our STAR Protocol paper of applying BRET to measure protein interactions in cells, with lead authors Carla J. Duval and Candy L. Steffen. Here is the link to "Protocol to measure and analyze protein interactions in mammalian cells using bioluminescence resonance energy transfer": https://lnkd.in/eskypw8q hashtag #cancerresearch, hashtag #Luxembourg

Excited to share that our study on the cell origin of IPMN is now published! This work would not have been possible without the dedications of my postdoc, Dr. Kiyoshi Saeki, and my collaborator, Dr. Janel Kopp. In our studies, we found that Acvr1b loss, likely through abrogation of Activin signaling, is one of the few pathways identified to date that promotes precancerous lesion formation from both acinar and ductal cells expressing Kras G12D. https://lnkd.in/ei6HcgF5

Join us for the first SACCMA Virtual Workshop Series 2024 event presented by ZEISS Microscopy!!! Come and learn more about your microscopy options when using Advanced Cell Modelling in your research. #organoid #3Dcellculture #bioimaging #spheroid #iPSC #cellmodelling

#ESCCA 2024 in Palma de Mallorca is going to start tomorrow! Please feel free to connect with the Beckman Coulter Life Sciences team, it will be our pleasure to discuss recent developments and to learn from you about your needs. Also, please don’t miss the scientific poster session, where our colleagues from R&D and Marketing will present the following topics (abstract numbers in parentheses): ·       A new automated flow cytometry method for #CD34+ hematopoietic stem and progenitor cell enumeration and analysis (HEM-18), ·       New anti-#TRBC2 (TCR Cβ2) antibody conjugates to simplify T-cell clonality research and assessment (HEM-44), ·       Method Agreement Performance Study of the #DxFLEX ClearLLab 10C Application System (HEM-57), ·       Precision performance of the DxFLEX ClearLLab 10C Application System (HEM-65), ·       Standardization of the #ClearLLab 10C Panel on a DxFLEX Flow Cytometer: A Comprehensive Study (HEM-66), ·       Toward Standardized AML-MRD Assessment In Clinical Research Studies And Trials Using Dry Antibody Panels (#DURA Innovations) (IMM-07), ·       Easy-to-use functional Natural Killer (NK) cells assay and associated stimulation reagent (IMM-08), ·       Development of new single-color reagents for flow cytometry fulfilling requirements from the In Vitro Diagnostic Device Regulation (#IVDR) (OTH-09), ·       New #supervised automatic analysis faithfully replicates expert manual gating for flow cytometric immune cell subset identification (OTH-10), ·       A fully automated, walkaway flow cytometry #workflow for immune cell subsets identification (OTH-11), ·       #CellMek SPS Instrument Performance: Gated populations with automated vs. manual sample prep using a 10-color antibody panel (OTH-16). I also would like to highlight the posters by Rarity Bioscience : ·       Ultra-sensitive molecular MRD by flow cytometry using superRCA mutation assay for NPM1 positive AML patients (HEM-46), ·       NRAS, WT1, NPM1 and IDH mutation detection for molecular MRD-assessment using Flow Cytometry in pediatric AML (HEM-51), ·       Use of the new superRCA mutation assay for molecular MRD monitoring using flow cytometry in pediatric AML (HEM-71). I look forward to seeing you!

👩🏻🔬 New study alert! We presented at #TAGC24 novel data produced by our laboratory system SydLab™ One in a new collaborative study with EPFL (École polytechnique fédérale de Lausanne) and Amsterdam UMC. Some insights: 🔬 High-content phenotypic analysis of a #Celegans recombinant inbred population identifies genetic and molecular regulators of lifespan 📊 Among the top candidates obtained from multi-omics data integration and QTL mapping, novel longevity modulators were identified and validated. 🚀 SydLab™ One was able to facilitate and speed-up the research via full automation of C. elegans developmental and #lifespan assay. #inwormwetrust Missed our presentation? Download the poster here 🔗👉🏼 https://lnkd.in/e2srcs9h #newpaper #aging #Celegans #labtechnology #microfluidics #OoC #HCS #labautomation #AIanalysis

Check our latest publication and learn how immuno-affinity chromatography can be used to isolate extracellular vesicles

If you work with #exosomes or #downstream processing of complex molecules and #biologics check the article below from #ibet.

Webinar alert: I'll be speaking tomorrow, Thu Oct. 10, on the challenges in detecting biological #nanoparticles (such as #exosomes), which have been implicated in everything from #Alzheimer's to many kinds of #cancer — but also hold much promise for both early detection and treatment of same. It's a very exciting field, really exploding now. Hope to see you there!

This past weekend I had the privilege to present a poster at the annual Biophysical Society meeting in Philadelphia. The poster, which you can view below, summarized work I did this summer under the guidance of Pablo Iglesias. Using the Virtual Cell program, we were able to simulate a biochemical network that models mechanosensation in Dictyostelium cells. Based on experiments conducted by our wonderful collaborator Douglas Robinson, we expected myosin II to accumulate at the site of external stress, together with cortexillin I and IQGAP2. Additionally, we expected IQGAP1 and MHCKc to inhibit this accumulation. Our model was built and verified using experimental data in wild type cells, as well as null cells. In addition to our null models, we were also able to simulate cells with overexpressed proteins, such as IQGAP1/2 or MHCKc. This work could not have been done without the help of Alma Plaza-Rodriguez and David Dolgitzer. Poster: https://lnkd.in/eVa2eNpC

📽 Unlike other cellular target engagement assays, NanoBRET® TE assays are quantitative for intracellular compound affinity (or apparent Ki), not just potency. Learn more from Senior Research Scientist, Matt Robers about how NanoBRET® TE stands apart from other methods in the video and link here 📝 https://bit.ly/3LYE6ug