JAMA Cardiology’s Post

Great Article on Recent Study by Susan Hughes in Medscape Challenges the Practice of Rapidly Lowering Blood Pressure (BP) in Acute Ischemic Stroke to Allow for Speedy Thrombolysis. https://lnkd.in/gHWzWGbx

Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial Werring, David JJelley, Benjamin et al. The Lancet, Volume 404, Issue 10464, 1731 - 1741 Early DOAC initiation within 4 days after ischemic stroke associated with atrial fibrillation was noninferior to delayed initiation for the composite outcome of ischemic stroke, intracranial hemorrhage, unclassifiable stroke, or systemic embolism at 90 days.

#MRCPl exam journey Day 10 #Nephroticsyndrome - #Clinical presentation: proteinuria, lipiduria, HTN and peripheral edema. - #For the exam: patient with peripheral #edema, #proteinuria and unilateral #flank pain: #Renal vein thrombosis due to decreased #AntithrombinlI.

A very important meta analysis regarding patients with A.Fib and stable CAD and the ideal anti-thrombotic therapy. From this meta-analysis. OAC monotherapy led to a significant relative risk reduction for major bleeding with similar rates of ischemic events and mortality compared to dual antithrombotic therapy in patients with AF and stable CAD. This is a paradigm change for patients with A fib and stable CAD. We can now consider the use of OAC monotherapy without use of antiplatele therapy as a strategy with lower risk of bleeding without compromising on risk of ischemic events and mortality.

OAC alone is superior on bleeding with similar ischemic event rates in patients with AFib and CAD: new meta-analysis of 3 trials. This appears to be the new optimal strategy.

#MRCPI exam journey Day 10 #Nephroticsyndrome - #Clinical presentation: proteinuria, lipiduria, HTN and peripheral edema. - #For the exam: patient with peripheral #edema , #proteinuria and unilateral #flank pain: #Renal vein thrombosis due to decreased #Antithrombin III.

In this months Prescriber Insights, We answer questions about the role of DAPT after a minor stroke. New data will raise questions about optimal use of short-term dual antiplatelet therapy (DAPT) after an ischemic stroke or TIA. We know that short-term DAPT...such as aspirin plus clopidogrel for 21 days...reduces recurrent stroke risk compared to aspirin alone. Read our article now to learn more.

Selective thrombosis is very effective

Systematic literature review IVIG in systemic sclerosis included 12 studies, 266 pts. A favorable effect was seen for skin thickening, MSK pain, GI Sxs, Steroid use, QOL. But less effect for pulmonary Dz, PFTs (stabilized?). Studies were not of high-quality

The Long QT Syndrome (LQTS) is characterized by prolongation of the QT interval in the electrocardiogram and associated with polymorphic ventricular tachycardia known as Torsades de pointes (TdP). The prevalence of congenital LQTS may be as high as 1/2000. Review how to identify and monitor the QT interval in this #ClinicalView white paper. #PatientMonitoring