Jonathan Douxfils’ Post

I am thrilled to share the news of the recent publication of my review article titled "A Comprehensive Review on Leucas aspera" in the prestigious International Journal of Pharma Research and Health Sciences. This comprehensive piece represents months of dedicated research and analysis into the pharmacological properties and therapeutic applications of Leucas aspera, a plant rich in medicinal potential. In this article, I delve deep into the diverse pharmacological activities exhibited by Leucas aspera, ranging from anti-inflammatory and antimicrobial to antioxidant and analgesic properties. By synthesizing existing literature and presenting new insights, the review sheds light on the promising role of this botanical wonder in modern medicine. I'm grateful for the invaluable mentorship of Dr.Pragyandip Parthasarathi Dash sir, whose guidance and expertise were instrumental in shaping my review article. Their unwavering support and insights have been pivotal in my professional growth. Thank you for believing in my potential and helping me refine my skills. I feel fortunate to have you as my mentor Dr.Pragyandip Parthasarathi Dash Sir. #firstpublication #reviewarticle #medicinalplant #leucasaspera #pharmacologicalactivity

Breakthroughs in Drug Discovery 👨🔬 👩🔬 Did you know? Drug discovery is a complex process that can take over a decade from initial research to market approval. Scientists use cutting-edge techniques like high-throughput screening and computer-aided drug design to identify promising compounds that can treat various diseases. It’s a meticulous journey from lab to pharmacy! #BRAINING European Commission, Jagiellonian University, Hospital del Mar Research Institute, Faculdade de Medicina da Universidade de Lisboa, University of Salamanca (Universidad de Salamanca)

Good news! DRPI-Europe 2024 submission deadline has been extended to May 25th. If you are doing research in any of the relevant areas listed below please consider entering this new dissolution-focused competition. In addition to the chance to win a prize and present your research to a panel of European judges, one finalist will be selected to compete in the international DRPI competition, where they will have the opportunity to showcase their work on a global stage. Please see the link in the post below for all details Relevant research areas: 1 Dissolution & Solubility Modulation 2 In vitro Release/Permeation Studies of Conventional & Novel Dosage Forms, including Herbals, Nutraceuticals & Cosmeceuticals 3 Pharmacokinetics & IVIVC Studies 4 Modified Dissolution Equipment & Methodologies, including Biorelevant Media & Automation 5 Computational Tools, PBPK Modelling

✨ Excited to Share Our Latest Research Publication! ✨ I'm thrilled to announce that our research article, titled "Rebamipide Nanocrystal with Improved Physicomechanical Properties and its Assessment through Bio-mimicking 3D Intestinal Permeability Model," has been successfully published in Nanoscale, a journal with an impressive Impact Factor of 5.8! 🎉 This work is the result of months of hard work, perseverance, and collaboration, exploring innovative solutions to enhance drug delivery and absorption. By developing a Rebamipide Nanocrystal, we have significantly improved its physicomechanical properties, aiming to optimize oral drug delivery for better therapeutic outcomes. Moreover, using a bio-mimicking 3D intestinal permeability model, we were able to assess the nanocrystal's enhanced permeability, simulating real physiological conditions.💊🧬 This accomplishment would not have been possible without the unwavering guidance and support of my mentors, Dr. Santanu Kaity and Dr. Shubhadeep Roy. Your insights, encouragement, and belief in this project have been instrumental in its success.✨ A heartfelt thanks to the entire team for their dedication, and to Nanoscale for the opportunity to contribute to this esteemed journal 👏 This journal is Accessible at: https://lnkd.in/gexHX5xg #Research #Nanotechnology #PharmaceuticalScience #DrugDelivery #Nanoscale #Publication #Innovation #Gratitude

🔬 B-Series Equipment -78 : Bacterial Culture Plate. Today, we’re highlighting the B-Series Equipment -78, an essential tool for bacterial culture plate management. This equipment is engineered to provide precise temperature control, crucial for maintaining the optimal conditions needed for accurate bacterial growth and culture. #MedicalEquipment #BSeriesEquipment #BacterialCulture #LaboratoryTech #ScientificResearch #PrecisionInScience #DailyUpdate #LabInnovation #MedicalResearch #EquipmentSpotlight

#analyticalchemistry news Embarking on an intriguing journey at the intersection of traditional medicine and modern analytical #chemistry, the latest research explores the anticoagulant potential of Xuefu Zhuyu decoction. Recently published in Analytical Methods, this study employs a cutting-edge technique: affinity-ultrafiltration coupled with mass spectrometry, to identify active components responsible for anticoagulation effects. The authors investigate how this traditional Chinese herbal formula can influence blood clotting. By employing advanced #massspectrometry techniques, they successfully discern bioactive compounds with potential medical applications. This innovative approach goes beyond conventional methods by offering deeper insights into how these natural compounds interact with biological systems, potentially paving the way for novel therapeutic applications. For those unfamiliar with Xuefu Zhuyu decoction, it is a traditional medicine used historically for promoting blood circulation and alleviating pain. The study's findings highlight its underlying biochemical mechanisms, providing a bridge between traditional wisdom and contemporary scientific evidence. Incorporating sophisticated analytical methods into the exploration of natural compounds poses an intriguing potential for new medicinal discoveries. This research not only underscores the importance of such integrative studies but also opens avenues for future innovations in the development of anticoagulant therapies. Ultimately, this work may contribute to safer, more effective treatments for conditions involving blood clotting, impacting healthcare practices and improving patient outcomes. #chemistry #anticoagulant #traditionalmedicine #affinityultrafiltration #analyticalmethods #massspectrometry, If you want to know more about #analyticalchemistry news, follow me: https://lnkd.in/d29pbjb9

#𝐂𝐄𝐃𝐇𝐔𝐂𝐏 𝐏𝐚𝐩𝐞𝐫 𝐌𝐨𝐦𝐞𝐧𝐭? 🔎 📌Our researchers Patrícia Batista and Patrícia Oliveira-Silva co-authored the article “Fucoidans: exploring its neuroprotective mechanisms and therapeutic applications in brain disorders”, in partnership with the CBQF - Centre for Biotechnology and Fine Chemistry, published in the 'Trends in Food Science & Technology'. The team's findings are a game-changer in both the food and pharmaceutical industries, revealing Fucoidan's diverse health benefits. 🔎 Key Findings: - Fucoidan boasts potent antioxidant and anti-inflammatory properties - It may positively influence our gut microbiota, proving its prebiotic potential. - Preliminary in vitro and in vivo studies show its effectiveness in neuroprotection. Read more 👉 https://rb.gy/o1iacs #UniversidadeCatólicaPortuguesa #UCP #CatólicaPorto #EnsinoSuperior #universidade #faculdade #FaculdadeEducaçãoPsicologia #FEPUCP #CEDHUCP #scientificpaper #brain #Fucoidan #neuroprotectivemechanisms #healthbenefits #CBQF Faculdade de Educação e Psicologia – Universidade Católica Portuguesa (Porto) Universidade Católica Portuguesa - Centro Regional do Porto Universidade Católica Portuguesa

🎉 Exciting News! 🎉 We are thrilled to announce that the groundbreaking discovery by researchers from HUN-REN Centre for Natural Sciences (HUN-REN TTK) has been featured as the cover story in the prestigious scientific journal, Science Signaling (Science Magazine)! This revolutionary research, a collaboration between Hungarian and Japanese researchers, paves the way for the development of signal transmission-selective drugs, which have significantly fewer side effects compared to traditional medications. These innovative drugs show promising results in pain relief, diabetes treatment, and heart failure therapy. Key highlights from the study include: 🔬 Understanding how signal transmission-selective physiological responses are formed. 🔬 Demonstrating the central role of receptor endocytosis in creating these selective effects and their spatial and temporal organization. 🔬 Recognizing that certain hormones use this mechanism to selectively trigger physiological responses. Congratulations to András Tóth, Bence Szalai, Professor László Hunyady, and their dedicated team at HUN-REN Centre for Natural Sciences, Institute of Molecular Life Sciences for this remarkable achievement! Hard work and collaboration with international researchers are making significant strides in medical science. 👏 Read more about this pioneering research in Science Signaling and join us in celebrating this scientific milestone! 🎉 https://lnkd.in/dJcZHath #HUNREN #Research #Innovation #Impact #Science #Healthcare #Pharmaceuticals #SignalTransduction #MolecularLifeSciences #ScientificDiscovery #PainRelief #Diabetes #HeartFailure

‘Forever chemicals’ like perfluorooctanoic acid (PFOA) have been linked to a host of health issues —from cancer to impaired fetal growth. 💡 Researchers at the A*STAR Singapore Institute of Food and Biotechnology Innovation (SIFBI), A*STAR Skin Research Labs (A*SRL) and the National University of Singapore pioneered a computational model that simulates how the human body handles PFOA. As a strongly charged molecule, PFOA cannot readily enter or exit human cells, often relying on transporters to get the job done. “All the known transporters of PFOA were responsible for pumping PFOA into kidney cells, but none were documented to pump it out,” explained James Chan, a Junior Principal Investigator at SIFBI and A*SRL. “We therefore hypothesised that there must be an efflux transporter that acts as a release valve to pump PFOA out of the kidney cells and back into the blood.” Get a behind-the-scenes look at their study in the article linked below ⬇️ --- #scicomm #science #technology #STEM #research #innovation #ASTAR #HHP #ASRL #SIFBI #toxicokinetics #health #foreverchemicals #collaboration #Singapore

Nanoplastics Can Reduce the Effectiveness of Antibiotics In a recent study, an international research team with significant involvement from MedUni Vienna has investigated how nanoplastic particles deposited in the body affect the effectiveness of antibiotics. The study showed that the plastic particles not only impair the effect of the drugs, but could also promote the development of antibiotic-resistant bacteria. The results of the study were recently published in the journal "Scientific Reports". Read more: https://lnkd.in/e7zXQRqJ #Nanoplastics #Antibiotics Medical University of Vienna #bacteria #StatNano #NBIC #nanotechnology