Joslyn Chaiprasert-Paguio’s Post

Tesofensine is a fascinating compound that has garnered attention for its potential impact on weight management. Originally developed for the treatment of neurodegenerative diseases, it was found to have a significant effect on appetite suppression and weight loss during clinical trials. The mechanism of action involves the inhibition of neurotransmitter reuptake, which enhances the levels of dopamine, serotonin, and norepinephrine in the brain. This results in reduced appetite and increased energy expenditure, making it a promising candidate for obesity treatment. As research continues, it's crucial to stay informed about the latest developments and understand both the benefits and potential risks associated with its use. The scientific community is actively exploring its long-term effects and efficacy in different populations. #Tesofensine #WeightManagement #ObesityResearch #Neuroscience #HealthInnovation

🌟 Exploring Potassium's Role in Brain Health! 🌟 By Nagihan Ozsoy and Mark Dallas from University of Reading Researchers highlight that the central nervous system (CNS) relies on the precise regulation of potassium ions (K⁺) to maintain its physiology. This delicate balance is crucial for various cellular functions and plays a pivotal role in inflammatory responses. Their latest review delves into the complex mechanisms that govern K⁺ homeostasis and its impact on inflammation. The findings indicate that disturbances in potassium regulation can lead to chronic inflammation, which is linked to several neurological disorders. By examining molecular targets that influence K⁺ levels across different cell types, they identify promising avenues for therapeutic interventions. Understanding these relationships provides insights into the molecular underpinnings of inflammation and opens doors for targeted drug discovery aimed at managing CNS inflammation. Join them in uncovering the vital interplay between potassium regulation and inflammation—key knowledge for developing effective therapies for brain health! 🧠✨ Read the full article here: https://lnkd.in/gk9EWSpk #BrainHealth #PotassiumHomeostasis #Neuroscience #Inflammation #TherapeuticInterventions #CNSResearch

The Rockefeller University disclosed biological markers which are molecular markers and predictive of brain pathology and clinical status and/or outcome in Parkinson’s disease (PD). The invention provides genes, RNA and protein markers that are associated with, relevant to, or predictive of Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD), Parkinson’s disease with dyskinesia or Parkinson’s disease duration. The present invention further provides methods, kits and markers for the identification and monitoring of disease and disease aspects in Parkinson’s patients and their application as markers and targets in and for evaluating, monitoring and treatment of Parkinson’s disease and relevant pathologies and conditions associated with or developing in Parkinson’s disease. https://buff.ly/3CN8C9r #mentalhealth #brain #health #wellness #humanity #psychology #healthybrain #happybrain #neuroscience #HBE #humanbrainexpo #3hbrain #science #AI #brainhealth #ethics #helpfulbrain #innovation #innovationmanagement #events #news #biotech #psychiatry

The Rockefeller University disclosed biological markers which are molecular markers and predictive of brain pathology and clinical status and/or outcome in Parkinson’s disease (PD). The invention provides genes, RNA and protein markers that are associated with, relevant to, or predictive of Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD), Parkinson’s disease with dyskinesia or Parkinson’s disease duration. The present invention further provides methods, kits and markers for the identification and monitoring of disease and disease aspects in Parkinson’s patients and their application as markers and targets in and for evaluating, monitoring and treatment of Parkinson’s disease and relevant pathologies and conditions associated with or developing in Parkinson’s disease. https://buff.ly/3CN8C9r #mentalhealth #brain #health #wellness #humanity #psychology #healthybrain #happybrain #neuroscience #HBE #humanbrainexpo #3hbrain #science #AI #brainhealth #ethics #helpfulbrain #innovation #innovationmanagement #events #news #biotech #psychiatry

⭐ The Brain is Not Sterile: A Paradigm Shift in Neuroscience 🧠🔬 🎲 For years, we have been taught that the brain is a sterile organ, free from microbial life, safely enclosed by the blood-brain barrier. This concept has shaped our understanding of brain health and disease. But recent studies are challenging this long-held belief. ✨ Emerging research suggests that the brain may, in fact, harbor a diverse microbiome. While still in its early stages, these findings have profound implications for our understanding of neurological health, inflammation, and disease processes. Just as the gut microbiome plays a crucial role in systemic health, it’s becoming increasingly clear that microbial interactions within the brain may influence conditions like Alzheimer's, Parkinson's, and even mental health disorders. 🚀 This revelation opens new doors for therapeutic strategies that target the microbiome to treat neurodegenerative diseases and psychiatric conditions. As we continue to explore this uncharted territory, the future of neuroscience looks exciting—blurring the lines between immunology, microbiology, and neurology. 🌟 It’s a reminder that our bodies are far more interconnected than we once believed. #Neuroscience #Microbiome #BrainHealth #Innovation #NeurodegenerativeDiseases #MedicalResearch #Personalizedmedicine #Personalizedmedicinejournal #Advancedtherapies #AdvancedtherapiesJournal

📢 New paper alert! Biomarkers have transformed Alzheimer's disease diagnosis, and a similar breakthrough is needed for Parkinson's disease and related disorders, known as Parkinsonian syndromes (PS). Recent research highlights corticotropin-releasing hormone (CRH) as a promising biomarker candidate for PS. Oskar Hansson and collaborators investigated this link, exploring CRH’s association with clinical symptoms like cognition and motor function, and its potential to differentiate between various neurodegenerative disorders. Read about their results here 👉 https://lnkd.in/d-jFSuYQ Lead authors: Atul Kumar and Bárbara Fernandes Gomes Co-authors: Nicholas Ashton, Sara Hall, Erik Stomrud, Ruben Smith, Henrik Zetterberg, Kaj Blennow, Niklas Mattsson-Carlgren Last author: Oskar Hansson Journal: Oxford University Press #Parkinson #ParkinsonianSyndromes #LewyBody #Biomarkers #CSF #CorticotropinReleasingHormone #AlphaSynuclein #Neuroscience background image generated by DALL-E

✨ A Memorable Encounter at the 5th International Conference on Microbiota and Microbiome in Health and Disease ✨ During the conference, I had the incredible privilege of meeting Dr. Giulio Maria Pasinetti, MD, PhD , a world-renowned researcher and academic. Dr. Pasinetti is the Saunders Family Chair in Neurology and a Professor of Psychiatry and Neurology at the Icahn School of Medicine at Mount Sinai, New York. His groundbreaking work focuses on the gut-brain axis, neurodegenerative diseases like Alzheimer’s, and therapeutic strategies for these conditions. Not only was his talk on the "Role of the Immune T Regulatory Cells in Mood Disorders and Alzheimer’s Disease Phenotype" absolutely fascinating, but it was also highly relevant to my own research interests in the gut-brain axis. He delved into how T-regulatory cells mediate gut-brain communication and their potential therapeutic implications—a topic that resonated deeply with me. Even more exciting was the opportunity to personally discuss our poster presentation ("The MPXV Epidemic: Targeting the A35R Protein Using Phage Display Library and Exploring Nanomedicines for Diagnostic and Therapeutic Approaches") with Dr. Pasinetti. His feedback was invaluable not only deepened my understanding but also inspired new perspectives on how I could approach similar challenges in research. Meeting such a passionate and accomplished scientist was a highlight of the conference for me. It reinforced my enthusiasm for exploring the complex and fascinating connections between the gut and the brain and encouraged me to keep pushing forward in my academic journey. #GutBrainAxis #Microbiota #NeurodegenerativeDiseases #Research #Networking #ScientificCommunity

White matter aging and its impact on brain function Aging leads to significant changes in white matter, characterized by volume reduction, compromised structural integrity of myelinated axons, and increased white matter hyperintensities. These alterations are strongly associated with cognitive decline and neurological disorders. The deterioration of myelin and its reduced regenerative capacity further contribute to the progression of neurodegenerative diseases. Understanding these age-related changes is crucial for developing effective disease prevention strategies. This review, published in Neuron: https://lnkd.in/dYGQKGbt, explores the structural alterations in white matter that occur with aging and examines the cellular and molecular mechanisms driving these transformations. It highlights how the progressive disruption of white matter may initiate a self-perpetuating cycle of inflammation and neural damage. #genetics #genomics #precisionmedicine #genomicmedicine #brain #glia #lipids #neurology #neuroscience #neurodegeneration #neuroinflammation #aging #longevity #dementia #cognition #alzheimer #parkinson #biomarkers #therapeutics #drugdevelopment #biotechnology #innovation #research #science #sciencecommunication

🧠🚬 Exploring the Relationship Between Smoking exposure and Parkinson’s Disease Our latest research, published in Parkinsonism and Related Disorders, explores the controversial link between cigarette smoking and Parkinson's disease (PD). Epidemiological studies have consistently shown an inverse association between cigarette smoking and Parkinson's disease. We conducted a pathology-validated case-control study, on a UK Brain Bank cohort, to understand whether smoking offers neuroprotective benefits or if reduced smoking is a consequence of early PD symptoms, according to the reverse causation theory. 🔍 Key Findings: - Complex Relationship: Our study suggests this association is not exclusive to idiopathic Parkinson's but extends to various parkinsonian disorders. - Potential Mechanisms: The protective role might be due to common neuroprotective effects of smoking or shared risk factors, or supports the reverse causation hypothesis where parkinsonian symptoms reduce smoking exposure. 📖 Read the full study for a deeper dive into our findings: - online version: https://lnkd.in/dYVCFfiX - pdf: https://lnkd.in/deiakZYi #ParkinsonsDisease #Neurology #MedicalResearch #PublicHealth #Neuroscience

Can a tiny protein really make a big difference? Discover how new research is uncovering the role of tau in brain health! Have you ever wondered why some people seem to maintain sharp minds well into old age while others face cognitive decline? Until recently, the answer remained elusive. But a groundbreaking study published this week has shed light on a crucial piece of the puzzle: the role of tau protein in oxidative stress. Tau proteins are vital for stabilizing structures in our brain cells, but when they become dysfunctional, they can contribute to neurodegenerative diseases like Alzheimer’s. The new research reveals how tau proteins, when altered, exacerbate oxidative stress, a harmful condition where harmful free radicals damage cells. This process can accelerate brain cell degeneration, leading to cognitive decline. Why is this significant? Understanding how tau proteins interact with oxidative stress can potentially lead to new therapeutic approaches. If we can develop strategies to prevent tau from causing damage or to repair its function, we might be able to delay or even prevent neurodegenerative diseases. This research brings us one step closer to such breakthroughs, offering hope for millions affected by these conditions. However, there’s more to be done. Future studies should focus on translating these findings into clinical applications. Researchers need to explore potential treatments that can specifically target tau-related oxidative stress. Additionally, more research is required to understand how other factors might influence tau protein functionality and brain health. In essence, this research provides a promising direction for tackling cognitive decline and improving quality of life for many. By continuing to investigate tau proteins and their effects, we might just be on the brink of a significant advancement in neurodegenerative disease treatment. #Neuroscience #BrainHealth #AlzheimersResearch #TauProtein #OxidativeStress #MedicalResearch #ScienceNews #HealthyAging #Neurodegeneration #InnovationInScience