Journal of Internal Medicine and Emergency Research’s Post

Consumption of food products rich in #antioxidants protects humans from #oxidative_stress and the resulting damage and minimizes the risk of #cardiovascular diseases, #cancer , and #diabetes. Antioxidant compounds play a key role in strengthening the immune system and preventing brain dysfunction. Many studies have shown that the prevalence of #neurological diseases such as cerebral ischemia, #Parkinson's and #Alzheimer's is lower in groups that receive antioxidant supplements. #Milk and #dairy products are a rich source of compounds such as sulfur-containing amino acids, #whey protein (especially β-LG), and vitamins A, E, and C, which have antioxidant properties. #atamad #danisco

Celiac disease is an autoimmune disorder that’s triggered when patient eat gluten, a protein found in wheat, barley, and other grains. The condition is also known as celiac sprue, nontropical sprue, or gluten-sensitive enteropathy. When someone with celiac disease eats or drinks something that contains gluten, the body overreacts to the protein. This damages their villi, small finger-like projections found along the wall of the small intestine. When villi are injured, small intestine can’t properly absorb nutrients from food. Eventually, this can lead to malnourishment and potentially to symptoms ranging from weakened bones to mood changes to miscarriage. Journal of Internal Medicine and Emergency Research (ISSN-2582-7367) is accepting submissions for the upcoming issue. Visit us: https://lnkd.in/g2YUP2sr Manuscript can be submitted to: internalmedicine@maplesjournals.com [Source: Internet] #celiac #autoimmune #gluten #intestine #protein #cilli #miscarriage #bones #wheat #grain

The biological responses of vitamin K2 are the reason why the inclusion of k2-rich lacto-fermented foods/drinks in our diet should be given greater consideration. In case of zinc deprivation (e.g.: viral zinc proteome competition), K2 affected cells levels become insufficient for normal functioning of as it directly or indirectly participates in and regulates hundreds of physiological or pathological processes. [The transcription factor Yin yang-1 (zinc finger protein) up-regulates UBIAD1 expression and UBIAD1 conversion activity of vitamin K1 and vitamin K3 to K2 MK-4 in several cell lines.] See: The biological responses of vitamin K2: A comprehensive review. Food Sci Nutr. 2023 Jan 6;11(4):1634-1656. Yan Q, Zhang T, O'Connor C, Barlow JW, Walsh J, Scalabrino G, Xu F, Sheridan H.  doi: 10.1002/fsn3.3213. PMID: 37051359; PMCID: PMC10084986. https://lnkd.in/duZfSEdi AND YY1 positively regulates human UBIAD1 expression. Biochem Biophys Res Commun. 2015 May 1;460(2):238-44. Funahashi N, Hirota Y, Nakagawa K, Sawada N, Watanabe M, Suhara Y, Okano T. doi: 10.1016/j.bbrc.2015.03.018. Epub 2015 Mar 12. PMID: 25772619. https://lnkd.in/d5GNM7g6 #cvd #cancer #Neuroprotection

Small clinical trials of #Taurine supplementation in adults have suggested benefits in metabolic and inflammatory diseases. Now, scientists have provided evidence of how taurine maintains health in aged mice and monkeys. https://lnkd.in/eVxdMKFQ Here is another interesting read about amino acids in energy drinks: https://lnkd.in/eGXqrzTx (amino acid in energy drinks)

Specific Microbiota may reduce Blood Cholesterol directly ! NOTES: - Species from the #Oscillibacter genus were associated with decreased fecal and plasma #Cholesterol levels. - human gut Oscillibacter isolates > conserved Cholesterol-metabolizing capabilities, including glycosylation and dehydrogenation. - Cholesterol metabolism is a broad property of phylogenetically diverse Oscillibacter spp. https://lnkd.in/gu2M85mg

NEW PUBLICATION ALERT‼️ I am delighted to share that our review paper “Gamma-aminobutyric acid as a potential postbiotic mediator in the gut-brain axis” is now published in Nature Partner Journal (NPJ) Science of Food. This work is co-authored by Dr. Masubon Thongnam and, my supervisor, Dr. Thanutchaporn Kumrungsee. In this review, we cover up-to-date information about GABA-producing microorganisms isolated from human gut and food sources, explanation why those microorganisms produce GABA, food factors inducing gut–GABA production, evidence suggesting GABA as a mediator linking between gut microbiota and mental health, including anxiety, depression, stress, epilepsy, autism spectrum disorder, and attention deficit hyperactivity disorder, and novel information regarding homocarnosine-a predominant brain peptide that is a putative downstream mediator of GABA in regulating brain functions. This review will help us to understand how the gut microbiota and GABA-homocarnosine metabolism play a significant role in brain functions. You can access the full paper using this link: https://lnkd.in/gjGqUeMa #gutbrainaxis #GABA #nutrition

🔍 Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding🧬💊 🌐 Background: The dance between our body and its microbial guests is key to our health's harmony 🔄. Tryptophan metabolites, crafted by our microbial allies, play a starring role in this interaction, influencing everything from our wellbeing to our vulnerability to diseases. Yet, the specifics of this microbial dialogue, especially how these metabolites foster communication between microbes, have been a bit of a mystery. 📊 Results Unveiled: Our recent exploration shines a light on indole-3-lactic acid (ILA), a marvel molecule from Lactobacillus, acting as a guardian against intestinal turmoil and microbial imbalance 🛡️🦠. By transforming tryptophan into ILA, Lactobacillus not only beefs up bacterial enzymes involved in tryptophan's tale but also paves the way for other indole derivatives like indole-3-propionic acid (IPA) and indole-3-acetic acid (IAA). These compounds emerge as heroes, battling intestinal inflammation and steering the gut microbiota towards equilibrium, showcasing their might in various colitis models 🌿🔬. Moreover, ILA fosters a communal table for microbes, boosting the production of IPA and IAA, particularly when the microbial community faces disruption 🔄. This solidarity, however, wanes when Lactobacillus loses its ability to produce ILA, underscoring ILA's pivotal role. 🎯 Conclusion: The findings illuminate the intricate web of interactions within our gut, where microbial byproducts not only converse with our body but also amongst themselves, orchestrating a symphony of gut harmony 🎶. link: https://lnkd.in/gcgqpvDf #Microbiome #GutHealth #TryptophanMetabolites #Postbiotics #MicrobialCommunication #InflammationPrevention #ResearchInnovation #ScienceHighlights

Metabolic liver diseases manifest uniquely, influenced by diet, gut microbiota, and genetics. Explore our latest review paper in The Journal of Nutritional Biochemistry (Elsevier) to uncover insights on leveraging #PrecisionMedicine for personalized liver disease treatment: https://lnkd.in/gp5REsVd #MASLD #MASH #GutMicrobiome

Impaired bacterial-associated #butyrate metabolism may be an #oxalate-independent mechanism that contributes to an increased risk for recurrent #KidneyStoneDisease (KSD) > Risk Factor. Abstract but containing the main message. NOTES: - No differences in the abundance of genes associated with known #oxalate degradation pathways, supporting the notion that dysfunction in other metabolic pathways plays a role in KSD. - KSD > decreased abundance of key enzymes involved in #Butyrate biosynthesis in patient intestinal microbiomes. - The majority of genes significantly enriched in non-stone formers are affiliated with #Faecalibacterium_prausnitzii, a major #Butyrate producer and the majority of abundant genes mapped back to F. prausnitzii, #Alistipes spp., and #Akkermansia_muciniphila. MyNote: Is now time to prescribe Butyrate as additional adjuvant therapy for patients suffering from various types of kidney stone disease (urinary stone disease)? https://lnkd.in/eEWW-Fgm

Vitamin K2 and MK7 metabolite reduce the severity and incidence of Nocturnal Leg Cramps https://buff.ly/3Afx964 It would be interesting to know if genetic variations of CYP4AF2 that metabolizes Vitamin K have a clinical impact on the risk of leg cramps and supplement's effectiveness.