Štefan Kosturko’s Post

Check out our recent cover article in New Journal of Chemistry 👇 "Guanidine modification improves functions of natural RNA-targeting alkaloids" https://lnkd.in/dBzg2et2

I am excited to share my 1st publication on "exclusive regioselective synthesis of Tetrahydrocarbazole core of akuammiline alkaloids" # JOC (Journal of Organic Chemistry).

Expanding the toolbox of covalent modification strategies in chemical biology by introducing allenes as potential weak electrophiles for targeted histidine modification. A new study reports the identification and characterisation of a novel covalent interaction between a novel allene warhead and the histidine residue (His32) in the active site of bacterial thiol-disulfide oxidoreductase enzyme Escherichia coli DsbA (EcDsbA). Though utilised in synthetic chemistry as electrophiles, Allenes have not been widely reported for their use as covalent warheads in bioorthogonal transformations. https://lnkd.in/gqkj-iZX

I'm excited to share that our latest paper is now published in the Journal of Organic Chemistry! We used a Ruthenium-based catalyst to synthesize quinolines with strong antibacterial, anticancer, antitumor, and antituberculosis properties. Read the full article here

Check out a recent publication in Organic Process Research & Development. 📌An amazing output showcasing SSPC expertise, industry collaboration with Eli Lilly and Company, featuring SSPC #talent. Lead author and SSPC alumnus Michael Carroll, Eli Lilly and Company, Aobha Hickey, Ava Rogers, a University of Limerick Bachelor of Science in Pharmaceutical and Industrial Chemistry placement student at Lilly, Cáoimhe Niland and Rachel O Sullivan, SSPC industry placement PhD students at the time, Muniraj Nachimuthu, Kevin O’Sullivan, Pat Guiry, University College Dublin, Michael Murray Improved reaction conditions have been developed for a telescoped Miyaura borylation/Suzuki coupling process, which is utilized in the synthesis of an abemaciclib intermediate. Key improvements include the in situ generation of a lipophilic base and tailored ligand selection for each palladium-catalyzed step. Optimizing ligand choice significantly reduced aryl scrambling, a major source of impurities in the borylation step. Additionally, the process improvements led to shortened reaction times and lower palladium loadings, resulting in a more efficient, higher-yielding process. https://lnkd.in/gQmXjpeM Research Ireland #Borylation #Inorganic #carbon #compounds #Ligands #Organic #compounds #Potassium

Exciting New Developments in Benzylboronate Chemistry!🧪 Researchers at the College of Charleston have published a comprehensive review on the recent advancements in using benzylboronic ester nucleophiles for organic synthesis. Some key highlights from the review: ✨ Activation of benzylboronates with alkyllithium reagents enables highly reactive boronate nucleophiles that can undergo 1,2-additions to aldehydes, imines, and ketones. ✨ Branched secondary and tertiary benzylboronates can also be utilized, providing access to functionalized tertiary alcohols and amines. ✨ The boronate nucleophiles can react with alkyl halides, demonstrating the versatility of this method for C-C bond formation, including examples with chemoselectivity. ✨ Copper catalysis enables reactions of the benzylboronates with epoxides, providing a new route to alcohol products. This review will be of great interest to organic chemists, particularly those working in the areas of synthetic methodology, catalysis, and C-C bond formation. The ability to leverage boronate nucleophiles opens up new possibilities for building molecular complexity. Check out the full article for all the details! https://lnkd.in/gW_RHAiG #OrganicChemistry #SyntheticMethods #Carbon-CarbonBondFormation #Catalysis #ChemistryNews SYNTHESIS Journal

Speaking of NMR, a new paper has been published in Food Chemistry. It explores the use of various high-field NMR techniques to identify the origin of different commercial teas. https://lnkd.in/dxi85teV

I am pleased to share our latest article published in the European Journal of Organic Chemistry. This is a journey into the chemistry of azoalkenes developed in our laboratory over the past fifteen years. https://lnkd.in/dXYCVsFG

I am proud to present our latest research published on Chemistry - An Asian Journal, which explores the reactivity studies of a MBHA derivative bearing a triphenylamine moiety toward different lysine models

What an innovative approach to harnessing the potential of isocyanides in drug discovery! This method not only simplifies synthesis but also opens up exciting avenues for creating novel pharmacophores. Kudos to the team for pushing the boundaries of medicinal chemistry! 👏 #DrugDiscovery #DrugDevelopment #MedicinalChemistry #Innovation #SharingUsefulContent