Naga Malleswara Rao Vampugani’s Post

Check out our recent cover article in New Journal of Chemistry 👇 "Guanidine modification improves functions of natural RNA-targeting alkaloids" https://lnkd.in/dBzg2et2

Samarium diiodide (SmI2) is a privileged, single-electron reductant deployed in diverse synthetic settings. However, generalizable methods for catalytic turnover remain elusive because of the well-known challenge associated with cleaving strong SmIII–O bonds. Prior efforts have focused on the use of highly reactive oxophiles to enable catalyst turnover. However, such approaches give rise to complex catalyst speciation and intrinsically limit the synthetic scope. Herein, Peters et al. leveraged a mild and selective protonolysis strategy to achieve samarium-catalyzed, intermolecular reductive cross-coupling of ketones and acrylates with broad scope. The modularity of our approach allows rational control of selectivity based on solvent, pKa (where Ka is the acid dissociation constant), and the samarium coordination sphere and provides a basis for future developments in catalytic and electrocatalytic lanthanide chemistry.

I am pleased to share our latest article published in the European Journal of Organic Chemistry. This is a journey into the chemistry of azoalkenes developed in our laboratory over the past fifteen years. https://lnkd.in/dXYCVsFG

Exciting New Developments in Benzylboronate Chemistry!🧪 Researchers at the College of Charleston have published a comprehensive review on the recent advancements in using benzylboronic ester nucleophiles for organic synthesis. Some key highlights from the review: ✨ Activation of benzylboronates with alkyllithium reagents enables highly reactive boronate nucleophiles that can undergo 1,2-additions to aldehydes, imines, and ketones. ✨ Branched secondary and tertiary benzylboronates can also be utilized, providing access to functionalized tertiary alcohols and amines. ✨ The boronate nucleophiles can react with alkyl halides, demonstrating the versatility of this method for C-C bond formation, including examples with chemoselectivity. ✨ Copper catalysis enables reactions of the benzylboronates with epoxides, providing a new route to alcohol products. This review will be of great interest to organic chemists, particularly those working in the areas of synthetic methodology, catalysis, and C-C bond formation. The ability to leverage boronate nucleophiles opens up new possibilities for building molecular complexity. Check out the full article for all the details! https://lnkd.in/gW_RHAiG #OrganicChemistry #SyntheticMethods #Carbon-CarbonBondFormation #Catalysis #ChemistryNews SYNTHESIS Journal

Fascinated in Amaryllidaceae alkaloids chemistry 🌿 ? Check our new research 🔬 focused on Zephyranthes alkaloids.

Happy (Belated) Birthday, Nikolai Matveyevich Kischner (November 26th 1867–1935) ! 🎉 Major Contributions 🔬 -Wolff–Kishner Reduction : Developed a pivotal method for converting ketones and aldehydes into hydrocarbons through the catalytic decomposition of alkylidene hydrazines. This reactions is still used a lot nowadays. -Small hydrocarbons cycle Chemistry : Explored transformations of alicyclic compounds, including the conversion of cyclobutane to cyclopentane, and created efficient methods to synthesize cyclopropanes from pyrazoline derivatives. -Early Hydrogenation Studies : Investigated benzene hydrogenation and isomerization mechanisms. #Chemistry #OrganicSynthesis #WolffKishnerReduction #CycloHydrocarbons #AlicyclicCompounds #ScienceHistory #HappyBirthday

I am excited to announce our latest research on the synthesis of indolizines, now published at Results in Chemistry journal! https://lnkd.in/de-sARZx In this study, we report the successful synthesis of a pyridinium salt by heating 2-chloropyridine with 2-bromoacetamide in a solvent-free environment. This salt demonstrated exceptional reactivity in nucleophilic substitution reactions with C-nucleophiles derived from acetonitrile. Moreover, the resulting N-carboxamide-2(1H)pyridines were efficiently converted into 2-amino-3-carboxamide indolizines via a cyclization process, achieving high yields. These findings pave the way for more efficient production of valuable indolizine derivatives with great potential in various applications! 🔗 Stay tuned for more updates on this work! #Research #Chemistry #Indolizines #OrganicSynthesis #Innovation #Publications

Exciting new developments in 1,3-enyne synthesis! The latest review paper in SYNTHESIS Journal covers comprehensive strategies for preparing this versatile motif, a key building block in organic chemistry. Authored by a talented team of researchers led by Chandi Malakar and Chinmoy Hazra, this in-depth review explores metal-catalyzed coupling, cyclopropane ring opening, and propargyl alcohol transformations as efficient routes to 1,3-enynes. Valuable insights on managing regio-, stereo-, and chemoselectivity are provided. A must-read for synthetic organic chemists, materials scientists, and natural product researchers working with 1,3-enynes and related intermediates. Check it out and let us know your thoughts!: https://lnkd.in/gDeD_tYF #OrganoMetallic #OrganicSynthesis #MaterialsChemistry #NaturalProducts #SyntheticMethodology

"Recent Developments Towards the Synthesis of Triazole Derivatives: A Review" From their Abstract Triazoles are a key part of heterocyclic chemistry, acting as essential building blocks in organic synthesis, materials science, and medicinal chemistry. They form a five-membered ring with three nitrogen and two carbon atoms and exist in two isomeric forms: 1,2,3-triazole and 1,2,4-triazole. Triazole compounds are noted for their wide range of biological activities, including antimicrobial, anticancer, and anti-inflammatory properties. This excellent review (open access) provides a comprehensive look at the synthesis of triazole derivatives, covering both traditional methods and modern techniques like microwave and ultrasound-assisted methods. Source: Issam Ameziane El Hassani et al. Recent Developments Towards the Synthesis of Triazole Derivatives: A Review. Organics 2024, 5, 450-471. https://lnkd.in/gj9tNzRY; https://lnkd.in/ggd3W4Tk #heterocyclic #1_2_3_triazole #1_2_4_triazole #microwave #ultrasound #green_chemistry #synthetic_reactions

RECENT DEVELOPMENTS TOWARDS THE SYNTHESIS OF TRIAZOLE DERIVATIVES, IN MEDICINAL CHEMISTRY Heterocyclic chemistry is a broad and important field within medicinal chemistry, due to its extensive applications in drug design and discovery. Heterocyclic bioactive molecules, which contain heteroatoms such as nitrogen, oxygen, and sulfur, play a crucial role in biological applications. Among these, azoles, which are five-membered heterocyclic compounds, are key structural components in various biologically active natural products. The core structures of azoles include triazole, oxazole, oxadiazole, tetrazole, pentazole, pyrazole, imidazole, thiadiazole, and thiazole ring systems. These compounds exhibit diverse biological activities, such as antibacterial, anticancer, antiviral, anti-inflammatory, antimalarial, and antituberculosis properties. Azoles possess several key characteristics of highly potent antifungal agents, and this class of compounds has played a crucial role in controlling both invasive and superficial fungal infections. Amongst azoles, triazoles are especially important heterocyclic compounds due to their excellent pharmacological properties and their role as essential components in cells and organisms. The term “triazole” was first introduced by Bladin in the early 1880s. Triazoles are heterocyclic compounds with molecular formula C2H3N3 consisting of a ring with three nitrogen atoms and two carbon atoms. They exist in two isomeric forms, 1,2,3-triazole and 1,2,4-triazole, which can exhibit tautomerism based on the position of the hydrogen atom. Triazoles interact readily with proteins, enzymes, and receptors in organisms, giving them a wide range of biological activities. These include antifungal, anticancer, antiviral, and antibacterial effects. Their derivatives have been extensively utilized in various medicinal scaffolds. For instance, Itraconazole (1992), Fluconazole (1990), and Voriconazole (2002), widely used antifungals. Ribavirin (2003), a broad-spectrum antiviral drug employed in the treatment of hepatitis. Rizatriptan (1998), an antimigraine agent. Letrozole (1997), Anastrozole (2000), Talazoparib (2018), and Vorozole (1984) as anticancer drugs. Rufinamide (2008), approved by the FDA for treating pediatric epilepsy. Tazobactam (1986) is an antibiotic, and Maraviroc (2007) is an anti-HIV drug. Issam Ameziane El Hassani et al., have just published (open access) in Organics 2024, a concise overview of triazole pharmacophore synthesis and serves as a valuable resource for researchers in the field. #Triazole #TriazoleChemistry https://lnkd.in/dzrq5aGA