Nederlandse Vereniging voor Endocrinologie’s Post

How Vision started? David H. Hubel and Torsten N. Wiesel’s Research on Optical Development in Kittens: [https://lnkd.in/dZg8Dy2p] David Hubel and Torsten Wiesel were neuroscientists who won the 1981 Nobel Prize in Physiology or Medicine for their work on the visual system and the cerebral cortex.

In today’s Nobel Prize lecture, Victor R. Ambros, PhD, of UMass Chan Medical School discussed growing up in New England as an amateur astronomer, the road to the discovery of microRNA and the collaborators along the way, and his current research on Argonaute syndromes, a rare class of neurodevelopmental disorders. Earlier this year, the Ambros lab was able to show in research published in the Proceedings of the National Academy of Sciences that the gene-silencing work of microRNA is disrupted by mutations associated with Argonaute syndromes: https://direc.to/m6ML “Argonaute syndrome is a very human phenomenon,” Dr. Ambros said during the lecture. “It involves patients, families, clinicians, support teams and so forth, and it’s the patients that are gifting to us the identity of their mutations that allows us to do experiments genetic or otherwise and make inferences about fundamental mechanisms that are going to apply how Argonautes and microRNAs work in all sorts of contexts, but at the same time we’re hopeful and optimistic that we can learn enough from these studies to be able to inform the disease.” Ambros and Gary Ruvkun, PhD, of Mass General Hospital and Harvard Medical School are the co-recipients of the 2024 Nobel Prize in Physiology or Medicine. Watch their lectures here: https://lnkd.in/eadV4DG8 📷: © Nobel Prize Outreach Clément Morin #NobelPrize #medicine #microRNA #AdvancingTogether #WhyUMassChan The Nobel Prize University of Massachusetts

Paratope Mining to Robotic Drug Screening. Eight decades after Dale’s seminal publication, our team painstakingly elucidated AchR binding sites' intricacies. Numerous 8-hour binding assays honed our expertise, fueling a series of publications. The 1990s' manual labor (precision membrane binding assays) sparked determination, driving me to pioneer high-throughput Radiation Medicine screening solutions. Successfully tackling NCI's challenge, our advancements hopefully should transform the related fields. #PapineniLABS #BCM #KUMC #NIH #NCI #SBIR #nciSBIR #Ionchannels #Radonc #Precisionmedicine #Biomedical #Cancer #NIAID #Nuclearmedicine #Barda #AACR #Oncology #Drugscreening.

Ivan Petrovich Pavlov (b. 9/14/1849) Nobel Prize in Physiology or Medicine 1904 "in recognition of his work on the physiology of digestion, through which knowledge on vital aspects of the subject has been transformed and enlarged" - Classical conditioning (also Pavlovian or respondent conditioning, Pavlovian reinforcement) is a form of associative learning that was first demonstrated by Ivan Pavlov (1927). The typical procedure for inducing classical conditioning involves presentations of a neutral stimulus along with a stimulus of some significance. https://lnkd.in/eQhF3rk

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Sudden unexpected death in epilepsy (SUDEP) claims more lives in the U.S. every year than SIDS. For nearly 3 million people living with epilepsy, the underlying cause of this phenomenon has remained a mystery. New research from the lab of SMU biology professor Edward Glasscock is beginning to provide valuable clues. In the findings, published in the journal Brain Communications, post-doctoral researcher Kelsey Paulhus shows that excitatory neurons within the brain’s corticolimbic circuits have a prominent role to play in both epilepsy and sudden lethal cardiorespiratory failure. Learn more: https://lnkd.in/gAQMC5K8

Prof. Ben Maoz, from the faculty of Biomedical Engineering and the Sagol School of Neuroscience, Tel Aviv University, let us into his lab to share his research. His research focuses on developing new methods for studying human physiology, specifically the brain. These innovative tools, called Organs-on-a-Chip, offer a fundamentally different approach to exploring human physiology. 🔬🧠

Did you know today is Nobel Prize Day? We'd like to recognize the groundbreaking work of Nobel laureates John O’Keefe, May-Britt Moser, and Edvard Moser. Their discoveries of 'place cells' and 'grid cells' have been crucial to Alzheimer’s research. Awarded the Nobel Prize in Physiology or Medicine in 2014, their work has helped uncover how memory and navigation are affected by neurodegenerative diseases, offering hope for future breakthroughs in treatment and, one day, a cure. Learn more about their extraordinary contributions and their impact on Alzheimer’s research here: https://lnkd.in/gPpP-psE Today, we reflect on the power of science to bring us closer to ending Alzheimer’s. #NobelPrizeDay #AlzheimersResearch #r2endalz

#Researcher2Know Spotlight! Today we feature Dr. Wolfgang Stein, Professor of Neurophysiology at Illinois State University. The Stein lab studies the mechanisms that allow neurons to generate activity that is robust against perturbations. They are particularly interested in how neurons deal with changing body conditions and environmental influences. Climate-change-driven temperature changes, for example, affect the nervous systems of billions of animals, and hyperthermia and fever can severely damage the human brain. One focus of their research is on neuromodulators that are released in the nervous system, like neuropeptides or monoamines, and how they allow neurons to continue to function during temperature perturbations. A second focus is on how sensory signals are processed in the nervous system, and how they affect neuronal activity. To learn more about Dr. Stein's work and other researchers, visit our R2K page! https://hubs.ly/Q02B8Sww0

Chet Mortiz, a C.J. and Elizabeth Hwang Endowed Professor in UW ECE, with joint appointments in rehabilitation medicine, physiology, and biophysics, is the lead author of a new study on non-invasive spinal cord electrical stimulation, which he is using in the Amplifying Movement & Performance (AMP) Lab to help restore hand and arm function for paralyzed individuals. The pictured study participant, Jon Schlueter, suffered a spinal cord injury in 2005 that severely limited the use of his arms and hands. By taking part in the study, Schlueter has been able to play guitar again. This groundbreaking work shows that 72% of study participants, like Schlueter, improved their hand strength and function. This research gives paralyzed individuals new hope for substantial functional improvements, and advances the fields of neurotechnology and rehabilitation. Learn more about how this work is changing lives in the link below. #uwece Chet Mortiz: https://lnkd.in/gWRsqCGg UW Physiology and Biophysics https://lnkd.in/gH67XBNS