Novoheart’s Post

Contractile performance is an essential function of the human heart. 2-D cardiomyocyte cultures are inadequate for assessing contractility as they cannot perform physiological contractions on rigid plasticware. Novoheart’s human ventricular Cardiac Tissue Strip (hvCTS) offers a superior contractility assay. This assay consists of aligned hvCM in a 3-D hydrogel mixture that is constructed using a custom-designed cartridge with integrated force-sensing posts at the ends. This model has been validated as a sensitive and reliable predictor of clinical drug responses or pathologic effects on cardiac contractility.  The CTScreen is Novoheart’s all-in-one screening system for comprehensive cardiac tissue contractility studies. Our unique system enables programmable force measurement protocols, including automated perfusion, electrical stimulation, data acquisition and streamlined data analysis. Customizable cartridges have been designed for the CTScreen to allow multiple tissues to be fabricated and cultured on each cartridge at the same time. All cartridges are compatible with Novoheart’s commercial CTScreen platform. #CTScreen #drugdiscovery #drugscreening #cardiac #3dcellculture #biotech #bioengineering

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