Olatec Therapeutics’ Post

Excited to share that the focus of my doctoral research is officially published! While Nrf2 is often discussed in the context of redox biology, we show it also plays a crucial role in controlling dendritic cell inflammatory responses and influences T cell skewing during respiratory superinfection. If you are interested, you can read more here:

#Leishmaniasis is a parasitic infection caused by the protozoan #parasite #Leishmania. According to the World Health Organization, up to 1 million leishmaniasis cases occur annually, and over 90 sandfly species transmit the Leishmania parasites. One of the three forms of the disease is fatal if left untreated in over 95% of cases. #UFEPI members Dr. Ana Maria Porras from the UF Herbert Wertheim College of Engineering and Dr. Kima Peter from the University of Florida Institute of Food and Agricultural Sciences put collaboration to the test. The duo joined forces to combine biomedical engineering, microbiology and cell science. Their #research uses in-vitro organ modeling to understand how Leishmania parasites affect liver tissues. This work can help improve technological applications used for studying parasitic infections. Watch the full video to learn more: https://bit.ly/3Sv3snf.

🚨 New paper 🚨 Bacteriophages (phages) are viruses that prey on bacteria. This study sampled natural phage populations to test the hypothesis that untapped genetic variation within a population can be the basis for the selection to diversify the host-range of a phage. Sampling of a waterway on Wurundjeri land revealed two populations of the phage Merri-merri-uth nyilam marra-natj (phage MMNM), differing by a single difference in a baseplate protein. This sequence variation changed the nature of bacterial killing in the lab. Further evolution of the phages led to a new generation of phages with more capability to kill the superbug Klebsiella. Read the full paper here: https://lnkd.in/g-ZPuYuP Alex Hall Afif Pranaya Jati Trevor Lithgow Monash Medicine, Nursing and Health Sciences Phage Australia #superbugs #AMR #phages

This Journal of Bacteriology publication starts with an ironic, "Don't Panic."(from the book, "Hitchhiker's Guide to the Universe"). Thank you Tufts University for this work by Linden Hu, MD about #Lyme disease and #Borrelia bacteria. "As covered in another review in this series, there is a need for “‘non-model’ model bacterial systems.” While the ability of E. coli to model bacterial cell and molecular biology has been drawn into question in numerous fields [even some genetic circuits between E. coli and the closely related Salmonella genus show a high degree of divergence], the ability to model B. burgdorferiusing E. coli can perhaps best be summarized by the immortal words of Dr. Ben Adler “Spirochetes do it differently!”" University of California, San Francisco Stanford University School of Medicine Tufts University School of Medicine Harvard Medical School Johns Hopkins Medicine Bay Area Lyme Foundation LymeDisease.org California Center for Functional Medicine Columbia University Centers for Disease Control and Prevention Kristen Honey Monica Embers Charles Chiu Felicia Chow American Society for Microbiology

What's new in the field of monoamine oxidases, mitochondria and inflammation ? 🤔 Check out our last review recently published in Redox Biology ! 😊 🔬 #mitochondria #inflammation #mitoDAMPs #monoamineoxidases

🌟 Exciting Curriculum News! 🌟 We're thrilled to announce an addition to our curriculum this academic year for third-year Biology students: an elective course "Parasitology and One Health"! 🦠🌿 Parasitism, the most ubiquitous lifestyle on Earth, holds secrets waiting to be uncovered. Beyond causing infectious diseases, parasites provide numerous ecosystem services and can even offer health benefits to their hosts. 💡 In this innovative course, students will delve into the fundamental concepts and recent research developments in the ecological and evolutionary aspects of parasitology. But that's not all – aligned with the "One Health" concept, we'll place significant emphasis on exploring the interconnectedness between the environment and the health and diseases (including infectious diseases) of humans, animals, and plants. 🌍👩🔬 Let's empower our students to unlock the mysteries of parasitology and embrace the holistic approach of One Health. 🚀 #Parasitology #OneHealth #EducationInnovation

I am happy to share that my latest research paper "Regulated proteolysis induces aberrant phase transition of biomolecular condensates into aggregates; a protective role for the chaperone Clusterin" is now published in the Journal of Molecular Biology! I am grateful to my co-authors, collaborators and everyone who supported this project. If you are interested, here is the link.

👩🎓CONGRATULATIONS to Dr Precious Mahlobo who obtained her PhD in Molecular Biology in March 🥳 Her research addresses knowledge gaps relating to tuberculosis (TB) disease caused by Mycobacterium tuberculosis (Mtb). It investigated the effectiveness of different face coverings in reducing infectious Mtb aerosols in TB patients and found that both conventional and non-conventional face coverings are effective. The study challenges the assumption that non-coughing patients are non-infectious, revealing that breathing produces infectious aerosols. It also provided evidence that anti-TB drugs reduce infectiousness after two weeks of treatment. In addition, a novel Sampler for In Vitro Aerosol (SIVA) was introduced to improve our understanding of Mtb aerobiology. #PhD #graduate #stellenbosch #university #tuberculosis #TB #molecularbioloy #TBinfection #aerobiology

School of Systems Biology Professor Fatah Kashanchi is diving into groundbreaking research on parasite-derived vesicles and their role in Babesia virulence and vaccine development. Babesia, a tick-borne parasite, can lead to serious health issues in humans, but Kashanchi’s work aims to unveil the potential of extracellular vesicles (EVs) in immune response modulation. With funding of $81,120 from Yale University and the National Institutes of Health, this study will investigate how these vesicles might recruit essential adapter proteins and activate inflammatory responses in immune cells. Learn more: https://lnkd.in/gAgjW7G2 #MasonScience #MasonScienceNews #MasonResearch #MasonSSB #BabesiaResearch #ParasiteResearch #VaccineDevelopment

The marine environment is still largely unexplored, although interest in exploiting novel bioactive natural products has grown exponentially in recent decades. Many marine organisms are the source of medicine used for human health, for example: - Ascidians provide trabectedin ET-743 (Yondelis) is used to treat soft tissue sarcomas a type of tumour. - Actinobacterium provide salinosporamide that is used to treat multiple myeloma, a type of cancer. - Sponges are the source of eribulin (Halaven), which is indicated for metastatic breast cancer and liposarcoma. - Sea hare supplies Dolastatin, a potent anti-mitotic used as a treatment for various autoimmune conditions To support the increasing demand and competitiveness of marine natural products in the drug discovery field, our project will build a new pipeline across the collaborating European Research Infrastructures @EuOpenscreen, @EMBRC_EU, @EMBL and @ELIXIREurope. Stay tuned! UiT Norges arktiske universitet | Fundacion MEDINA | Universiteit Gent | Tel Aviv University | Helmholtz Centre for Infection Research | @SINTEF | Centre of Marine Sciences (CCMAR) | Consiglio Nazionale delle Ricerche | Sorbonne Université | European Research Executive Agency (REA)| Stazione Zoologica Anton Dohrn | CNRS #euremap #marinebioprospectioning #blueeconomy #EU_RIs