Oxford Venture Capital Network’s Post

Quick recap of Cell culture....#cellculture #immunology #celldifferentiation

Another week, another roundup of the key happenings in biotech. Here’s what you need to know from the past week. 1. Nobel Prize in Chemistry Recognizes AI Breakthroughs The 2024 Nobel Prize in Chemistry was awarded for advancements in predicting protein structures using AI, with the spotlight on AlphaFold2's impact in accelerating drug discovery and synthetic biology. Learn more: https://lnkd.in/eNCBrWii (Scientific American) 2. Graphene Oxide Enhances CAR-T Cell Therapy Researchers at UCLA demonstrated that using graphene oxide can significantly boost CAR-T therapy's effectiveness by improving T cell activation and engineering efficiency, potentially reducing costs and enhancing outcomes. Learn more: https://lnkd.in/dfSKNZ-H (Inside Precision Medicine) 3. Lipid Metabolism's Role in Cancer Immunotherapy New research highlights how lipid metabolism affects CD8+ T cell functions within tumors, suggesting that targeting lipid metabolic pathways could significantly enhance cancer immunotherapy efficacy. Learn more: https://lnkd.in/eP43P667 (Nature Magazine) 4. Repurposing Old Chemo Drugs with New Insights A study revealed that the chemotherapy drug 5-fluorouracil (5-FU) fights GI cancers through RNA damage rather than DNA disruption, suggesting alternative treatment combinations to improve patient outcomes. Learn more: https://lnkd.in/e5GucXfr (Gen Eng News) 5. Bacteria Sense Seasonal Changes Even single bacterial cells can anticipate seasonal shifts, with cyanobacteria adjusting their cell membranes to prepare for winter. This discovery underscores the deep evolutionary roots of biological rhythms. Learn more: https://lnkd.in/gdNC5EQf (Quanta Magazine) Which breakthrough excites you the most? Let us know in the comments, and follow us for more industry insights. #biotech #celltherapy #pharma #research #healthcare #innovation #insights

Cell culture and Animal model works are completely trending.....

Organoids in Biotechnology: The Key to Personalized and Ethical Drug Development Imagine a world where we can test drugs on mini versions of human organs grown in a lab—no animals involved, no guesswork about human compatibility. Sounds futuristic? It’s already here! Organoids, also known as mini-organs, are revolutionizing biomedical research. These 3D structures mimic the architecture and functionality of real human tissues. Derived from stem cells, organoids can replicate the complexity of organs like the brain, liver, kidney, and even the gut. Significance: 1. Precision Drug Testing: Traditional methods often rely on animal models that don’t always translate to human biology. Organoids allow us to test treatments in a setting that mimics real human conditions. 2. Personalized Medicine: Patient-derived organoids enable testing drugs tailored to individual genetic profiles. Think about cancer treatments customized to your tumor cells. 3. Faster Discoveries: Organoids streamline the process of identifying effective treatments, accelerating the journey from lab to clinic. Organoids aren’t just transforming pharmaceuticals—they’re helping us understand diseases better. From neurodegenerative disorders like Alzheimer’s to infectious diseases like COVID-19, researchers are using organoids to uncover how these conditions progress and how to stop them. While organoids hold immense promise, challenges like scalability and replicating complex inter-organ interactions remain. But with advancements in bioengineering, AI, and regenerative medicine, the future looks bright. What excites you most about organoid technology? Share your thoughts in the comments below! #Biotechnology #DrugDiscovery #Organoids #FutureOfMedicine #Innovation

Checkout the Biolaminin 521 CTG™ Cell Culture Substrate by BioLamina — available now at FroggaBio! Enhance your cell culture with this innovative product that provides a stable and defined environment for pluripotent stem cell expansion. 🐸🧪🧫 LEARN MORE: https://hubs.li/Q02FDpY70 The Biolaminin 521 CTG™ is a cutting-edge solution for researchers and scientists looking to optimize their cell culture conditions. With its unique formulation, it offers superior performance in maintaining the pluripotency and self-renewal of stem cells. This product is ideal for various applications, including regenerative medicine, drug discovery, and disease modeling. Take your research to the next level with Biolaminin 521 CTG™! 💡🔬 #StemCells #CellCulture #PluripotentStemCells #RegenerativeMedicine #DrugDiscovery #DiseaseModeling #CellExpansion #ScientificResearch #CellTherapy #Biolaminin #Biolaminin521 #CellBiology #CellBasedAssays #CellularResearch #TissueEngineering #BiomedicalResearch #Innovation #AdvancedTechnology #Academics #Academia #Research #Researchstudy #Scientific #Science #Biology #Biotechnology #Biotech #Lifescience #Lifesciences #FroggaBio

New antibody capture method reveals insights into alternative DNA structure, G-quadruplexes. 🧬 G-quadruplexes are a promising target for cancer therapy, as its formation has been demonstrated to drive genome instability by creating mutations, deletions and triggering recombination events. A recent paper describes the DNA G-quadruplex (G4) landscape and its regulation through a novel protocol that captures G4s from the cells efficiently without any bias as well as eliminates the detection of G4s formed artifactually on crosslinked sheared chromatin post-fixation. The current understanding of the G4 landscape is biased against representation of G4s which escape crosslinking. Several G4-binding proteins have been described with no evidence for any protein that binds to and stabilizes G4s. With the new antibody capture method, the researchers found that sequence property-specific constraints of the nuclear environment mitigate G4 formation.   Read the full paper here: https://lnkd.in/egC-ZE2q   #Biointron #Antibodies #DNA #Genetics #Oncology #Innovation #Research

Using a Vertical-Wheel Bioreactor to produce extracellular vesicles from human forebrain spheroids: in their latest work, Chang Liu, Yan Li at Florida State University and collaborators differentiated human induced pluripotent stem cells into forebrain spheroids using Vertical-Wheel Bioreactors. Extracellular vesicles were isolated from the spent culture media and characterised in terms of size, yield, purity, and biomarkers https://lnkd.in/eVxxbXbn Their protein and miRNA cargo profiles were further analysed through multi-omics approaches. This workflow opens new opportunities for utilising these EVs in drug delivery and cell-free therapies, particularly in preclinical applications. An article co-authored by Li Sun, Hannah Worden, Justice Ene, Olivia Zeng, Jamini B., Samuel Grant, Xiaoping Bao and Sunghoon Jung #extracellularvesicles #exosomes #bioreactor #stemcells #aggregates #Vesiculab

Axol Bioscience Secures SMART Grant to Accelerate the Development of a Commercial iPSC-Powered ALS Models - https://lnkd.in/ghTe_uFr Axol Bioscience has been awarded a SMART Grant by Scottish Enterprise to Accelerate ALS Research through the development of ALS-related phenotypes using human iPSCs. This represents another significant step towards better disease modelling and ALS drug discovery. The key objectives of this project are to: -Develop a quality manufacturing system for iPSC-derived ALS relevant cell types - Characterise and validate the cells using ALS relevant end points; TDP43 aggregation, Neurofilament Light elevation and Cryptic Exon Sequencing - Develop and characterise an ALS co-culture model which includes motor neurons, microglia and astrocytes - Commercialise an easy-to-use model system to drive forward ALS drug discovery Axol Bioscience Ltd., who is a world leaders in human induced pluripotent stem cell (iPSC) manufacturing, consistently and at scale, has been awarded a SMART Grant by Scottish Enterprise. This significant milestone is a testament to its commitment to advancing cutting-edge research and innovation in the iPSC space. #ipscells #stemcells #ALS #drugdiscovery #reserach Duncan Borthwick PhD Teodora Popovici

The future of laboratories in healthcare biotechnology is set for transformative advancements driven by genomic and proteomic innovations. Laboratories will increasingly enable personalized medicine through comprehensive genomic profiling, optimizing treatment specificity and efficacy. Innovations in stem cell research and biomaterials will facilitate regenerative therapies for repairing damaged tissues, while rapid, portable diagnostic assays will enhance real-time disease monitoring, improving clinical decision-making. The integration of artificial intelligence and machine learning will refine laboratory workflows, enabling the extraction of complex biological insights from extensive datasets. Moreover, laboratories will play a critical role in the production and quality control of advanced therapies, including CRISPR-based gene therapies and CAR-T cell therapies. Collaborative efforts among laboratories, academic institutions, and industry stakeholders will foster an open innovation ecosystem, expediting the translation of discoveries into clinical applications. Ultimately, the evolution of laboratories in healthcare biotechnology will prioritize precision and patient-centered care, significantly enhancing therapeutic outcomes. #HealthcareBiotechnology #ArtificialIntelligence #MachineLearning #CRISPR #CAR_T #BiotechInnovation #Therapeutics #ClinicalResearch #LaboratoryScience #HealthTech #LondonBiotechnologyShow #LBS25

🎉 Congratulations to Anna-Maria Makri-Pistikou on successfully defending her dissertation at BmE! 🎓   For her thesis, Anna-Maria made innovative strides in the development of synthetic receptor systems for cellular therapies. 🌟   Her work focused on designing a scalable and modular communication system for mammalian cells that can communicate with both natural and synthetic cells. Additionally, using microRNAs, she proposes how to introduce control of synthetic receptor activation to prevent side effects, representing a giant leap forward in cell diagnostics and cell therapies. 🔬   These advances have profound implications for both basic and applied biomedical research. 🙏   Read more about Anna-Maria's research here: https://lnkd.in/g7zztpAK   #Biotechnology #CellTherapy #Science #PhDdefense