Philip Morisky, MBA, Ξ’s Post

📃Scientific paper: Facilitators and barriers to infant post-natal HIV prophylaxis, a qualitative sub-study of the PROMISE-EPI trial in Lusaka, Zambia Abstract: Background Infant post-natal prophylaxis (PNP) is used to prevent HIV transmission through breastfeeding. The WHO edited recommendations but so far there is no consensus on the duration of prophylaxis and the type of drug used depends on national guidelines. In Zambia, the national recommendations include a three-drug prophylaxis, composed of a dispersible combined tablet of zidovudine (AZT) and lamivudine (3TC) and an oral suspension of nevirapine (NVP) for 12 weeks or until the mother’s viral load is <1,000 cp/mL. The PROMISE-EPI study, modified the PNP regimen to lamivudine only, initiated at 6 weeks and continued until 12 months to all HIV exposed uninfected infants of virally unsuppressed mothers. Our aim in this analysis was to identify barriers and facilitators to this extended PNP, the keystone toward an effective prevention. Methods Individual interviews and focus group discussion (FGD) were conducted with PROMISE-EPI participants who had received prophylaxis for their children from the national program up to 6 weeks and then lamivudine oral solution in PROMISE-EPI study. Health care providers and PROMISE-EPI staff were also interviewed. Sessions were recorded, transcribed verbatim and translated from local languages into English. An initial code-book was designed and then adapted on the basis of the emerging themes, to allow a descriptive thematic analysis. Results More barriers to PNP adherence were identified with triple drug prophylaxis than with la... Continued on ES/IODE ➡️ https://etcse.fr/o24Lv ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

As participants gather at the International AIDS Conference 2024 to discuss the latest in HIV research & good practice, it’s crucial to emphasise the intersectionality of health challenges. TB remains a significant co-morbidity among PLHIV, necessitating holistic care & effective treatment strategies. Integrating TB discussions into the conference agenda is not just about addressing another disease; it's about saving lives & improving health outcomes. TB is the 2nd leading cause of death globally, after COVID-19. The synergy between HIV and TB research & practice can lead to breakthroughs that benefit millions worldwide, but especially in regions with significant HIV & TB syndemics. Important to use this platform to advocate for comprehensive & integrated healthcare solutions. By being more deliberate about twinning and amplifying TB together with HIV at (& not only on the sidelines of) the conference, I am convinced we can collectively advance towards a future where the fight against infectious diseases reaps greater benefits. Together, we can make a difference.

In our latest article in Hospital Pharmacist's Letter, we explore the importance of safe transitions of care for patients living with HIV. Shockingly, medication errors may occur in over 80% of hospitalized patients with HIV. To ensure safe transitions of care, we recommend working closely with your infectious disease colleagues to establish an antiretroviral stewardship program. Additionally, consider the following strategies: - Admission: Use an EHR-generated list to identify patients with HIV, including those with positive tests or taking antiretrovirals. Talk to patients to determine their regimen and assess adherence. By taking these steps, we can better support patients living with HIV and ensure they receive the safe and effective care they deserve. #HIVcare #TransitionsOfCare #PatientSafety

These are really encouraging stats for Scotland’s journey toward zero new HIV transmission by 2030! 📉📈 The significant reduction in new diagnoses, increased use of HIV pre-exposure prophylaxis (PrEP), and early detection efforts are all steps in the right direction. Let’s keep up the momentum to #GetToZero and a Scotland where anyone living with or at risk of HIV can expect to be treated with acceptance, support and respect.

🔬 Gut Integrity: The Silent Battle in HIV Infection - Recent studies reveal that HIV doesn't just attack the immune system—it disrupts gut integrity early on. Within days of infection, critical proteins like Claudins and Zonulin break down, leading to microbial translocation and systemic inflammation. 🦠 - This damage starts before the immune system even kicks in, underscoring the importance of addressing gut health in HIV treatment. Elevated levels of markers like IFABP and sST-2 in the bloodstream are just the beginning. - Could targeting gut integrity be the key to reducing inflammation and improving outcomes in HIV patients?----> Let CLOSE THE SINK !!! Let’s explore how early intervention in the gut might change the course of HIV treatment. 💡 hashtag#HIV hashtag#GutHealth hashtag#MedicalResearch hashtag#InfectiousDiseases hashtag#ScienceAndMedicine

The FDA has approved the use of Dovato in treating HIV-1 infection in adolescents aged 12 and above weighing at least 25 kg. This approval is a significant milestone, as it is the first oral, two-drug, single-tablet regimen available for adolescents living with HIV. Dovato is a combination of dolutegravir and lamivudine, which work together to inhibit the virus at two different stages of its replication cycle. Based on data from the DANCE study, the majority of adolescents who took Dovato achieved and maintained viral suppression for 48 weeks. The safety and efficacy of Dovato in adolescents were comparable to those observed in adults, with no clinically significant adverse effects noted despite higher exposures to the components of Dovato. This expanded indication for Dovato provides adolescents with a more convenient and effective treatment option that requires fewer medications. It underscores ViiV Healthcare’s commitment to developing and delivering innovative therapies for people living with HIV, including young people. According to Lynn Baxter, Head of North America at ViiV Healthcare, this approval is an important step in addressing the treatment needs of young people with HIV. As a leader in HIV care, ViiV Healthcare remains dedicated to improving and expanding treatment options for children and adolescents, particularly in communities where access to care may be limited. #HIVtreatment #Dovato #ViiVHealthcare #adolescenthealth #innovativetherapies #FDAapproval

The latest HIV in Scotland report from Public Health Scotland is out today! Here are some key highlights: 📉 New HIV reports from first-ever diagnoses have decreased from 60% in 2018 to 33% in 2023. 🛡️ 1,277 individuals accessed pre-exposure prophylaxis (PrEP) for the first time between 1 July and 31 December 2023. 📈 Heterosexually acquired first-ever HIV diagnoses has now exceed those among gay, bisexual, and other men who have sex with men. ⬇️ Lowest proportion of first-ever diagnoses at a late stage of HIV infection were recorded. Read the full report here: 👉

Celebrating American Pharmacists Month During October, American Pharmacists Month, three pharmacists with HHS's Office of Infectious Disease and HIV/AIDS Policy (OIDP) share their thoughts on the profession and the important role that pharmacists play in health care with HIV.gov. This year's theme is Caring for Our Communities. Lieutenant Commander Neelam 'Nelly' Gazarian, PharmD, MS, AAHIVP, notes that pharmacists play a key role in all aspects of health care in the United States. "Nowhere is this more evident than their expanding role in HIV prevention, especially through PrEP and PEP services," says Gazarian. "Pharmacists are often the most accessible health care providers, close to patients and embedded in their communities. Their work is critical in addressing the syndemic of HIV, STIs, and other diseases." Ronald J. Levinson, PharmD, HIV and STI Research ORISE Fellow, OIDP, adds that pharmacists are everywhere. "We're often the most accessible health care provider communities rely on, providing expert advice on prescription use, over-the-counter medications, and other health concerns a patient may have. Our accessibility is crucial in times of public health crises," says Levinson. Pharmacists' administration of vaccines during the COVID-19 pandemic is just one example of this. Shary M. Jones, PharmD, MPH, BCPS, CAPT, U.S. Public Health Service, Director, OIDP Engagement Team Region 6, further points to how American Pharmacists Month acknowledges the critical role of pharmacists in the public health infrastructure. "Our proximity to patients allows us to identify and respond quickly to the compounding effects of syndemics," she says. "By recognizing this month, we highlight how pharmacists are more than medication experts — we are vital public health advocates working at the frontlines of syndemic care to improve the well-being of the communities we serve."

https://lnkd.in/d5jSidt8 I came across this link via X and I thought I'd share something about (PreP) today. The question that lingers in my head is do we consider this reckless or do they actually care about their health? Read and let's engage Pre-exposure prophylaxis (PrEP) is a crucial component in the management of HIV, offering a proactive approach to preventing the transmission of the virus among "high-risk populations". This intervention involves the use of antiretroviral medications by individuals who are HIV-negative but at *substantial* risk of infection. By adhering to a prescribed PrEP regimen, individuals can significantly reduce their chances of acquiring HIV. The implementation of PrEP not only contributes to individual health outcomes but also plays a vital role in achieving universal healthcare goals. By preventing new HIV infections, PrEP helps reduce the burden on healthcare systems, decreasing the need for costly HIV treatment and long-term care. Furthermore, the widespread adoption of PrEP can lead to a decrease in HIV transmission rates, ultimately contributing to the overall public health and well-being of communities. In the pursuit of universal healthcare coverage, integrating PrEP into existing healthcare systems can enhance access to preventive services and promote health equity among diverse populations. By prioritizing the availability and affordability of PrEP, policymakers and healthcare providers can work towards ensuring that all individuals, regardless of their socioeconomic status or geographical location, have access to this life-saving intervention. Embracing PrEP as a cornerstone of HIV management not only improves individual health outcomes but also advances the collective goal of achieving universal healthcare for all. #PHC #UHC #MOH #Familyhealth

HIV & AIDS What are they? HIV: A virus that weakens the body's defense system (immune system). AIDS: The most advanced stage of HIV infection, when the immune system is severely damaged. How does it spread? Unprotected sex with someone who has HIV Sharing needles or syringes with someone who has HIV From a mother to her baby during pregnancy, birth, or breastfeeding (with proper care, this risk is very low) Very rarely (in countries with safe practices), through blood transfusions or organ transplants How to prevent it? Using condoms if there ever is casual sex. Getting tested regularly for HIV and encouraging sexual partners to do likewise. For those who inject drugs, use new needles and syringes every time. There are medications - Pre-exposure prophylaxis (PrEP) - that can help prevent HIV for people at high risk. Pregnant women with HIV can take medication to greatly reduce the risk of passing it to their baby How is it treated? There is no cure, but medication - Anti Retroviral Treatment (ART) - can control the virus, keep the immune system strong, and help to live a long, healthy life. Early diagnosis and taking medication regularly cannot be overemphasized. Ending the stigma! Some people wrongly fear or judge those with HIV. This is unfair and can stop people from getting tested and treated. Let's spread knowledge, not fear. Educate ourselves and one another and end discrimination. Extra Help There are many resources available, including counseling, support groups, and healthcare services. You are not alone! #HIVAwareness #EndStigma #KnowYourStatus #hiv #aids