Philippe Tschopp’s Post

𝗔𝗻𝗮𝗹𝘆𝘀𝗶𝘀 𝗼𝗳 𝗣𝗼𝘄𝗱𝗲𝗿 𝗣𝗿𝗼𝗽𝗲𝗿𝘁𝗶𝗲𝘀 𝗼𝗳 𝗣𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹 𝗘𝘅𝗰𝗶𝗽𝗶𝗲𝗻𝘁𝘀 𝗨𝘀𝗶𝗻𝗴 𝗮 𝗖𝗼𝗻𝘀𝘁𝗮𝗻𝘁-𝗩𝗼𝗹𝘂𝗺𝗲 𝗦𝗵𝗲𝗮𝗿 𝗧𝗲𝘀𝘁𝗲𝗿 Powders used in pharmaceuticals require good flowability. The angle of repose and compressibility index are often used to measure the flowability of pharmaceutical powders. However, confirming the relationship between external forces and flowability for smooth powder handling is necessary. Therefore, we measured pharmaceutical excipient powder using a lower cell direct movable constant-volume shear tester and evaluated the powder’s physical properties. In this study, we utilized microcrystalline cellulose, widely used as a pharmaceutical excipient and developed in many grades with different physical properties such as particle shape. We measured the shear parameters that describe the characteristic friction and cohesion properties of each microcrystalline cellulose grade. We found that the relative compression ratio (RCR) correlated with the angle of repose. Differences in the shape of the powder yield locus were observed among the grades, and the ratio of the upward convex area of the powder yield locus curve (APC) was defined as the value that quantified these differences. The study used various grades of #Ceolus #microcrystallinecellulose by Asahi Kasei

𝗔𝗹𝘁𝗲𝗿𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗴𝗲𝗹 𝗽𝗼𝗶𝗻𝘁 𝗼𝗳 𝗽𝗼𝗹𝗼𝘅𝗮𝗺𝗲𝗿 𝟯𝟯𝟴 𝗶𝗻𝗱𝘂𝗰𝗲𝗱 𝗯𝘆 𝗽𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹 𝗮𝗰𝘁𝗶𝘃𝗲𝘀 𝗮𝗻𝗱 𝗲𝘅𝗰𝗶𝗽𝗶𝗲𝗻𝘁𝘀 Poloxamer 338 is used as versatile thermo-responsive gelling agent in topical and sub-cutaneous applications. Due to application specific needs a gel point below body or even below room temperature is required. The influence of inorganic salts and active pharmaceutical ingredients (APIs) on the gel point was investigated using oscillatory rheology to identify the driving forces and predictors for gel point alteration. While most inorganic salts decreased the gel point, API salts exhibited an increase. Consistent with previous findings, the extent of gel point alteration caused by inorganic salts could be empirically described by the Hofmeister series, primarily influenced by the anion. Notably, this study revealed a concentration-dependent increase in the gel point in the presence of API salts. Moreover, this increase could be accurately predicted in a linear manner by considering the respective logP value. By utilizing the proposed prediction model, the effect of API addition on the gel point can be estimated, facilitating formulation development to achieve the desired gelling behavior for specific applications. Read more in the article: https://lnkd.in/eAeXNDHw

𝗥𝗲𝗹𝗮𝘅𝗮𝘁𝗶𝗼𝗻 𝘁𝗲𝘀𝘁𝘀 𝗳𝗼𝗿 𝘁𝗵𝗲 𝘁𝗶𝗺𝗲 𝗱𝗲𝗽𝗲𝗻𝗱𝗲𝗻𝘁 𝗯𝗲𝗵𝗮𝘃𝗶𝗼𝗿 𝗼𝗳 𝗽𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹 𝘁𝗮𝗯𝗹𝗲𝘁𝘀: 𝗔 𝗿𝗲𝘃𝗶𝘀𝗲𝗱 𝗶𝗻𝘁𝗲𝗿𝗽𝗿𝗲𝘁𝗮𝘁𝗶𝗼𝗻 by Vincent Mazel and Pierre Tchoreloff Relaxation tests are often used in the pharmaceutical field to assess the strain rate sensitivity of pharmaceutical powders and tablets. These tests involve applying a constant strain to the powder in the die and then monitoring the stress evolution over time. Interpreting these tests is complicated because different physical phenomena, mainly viscoelasticity and viscoplasticity, occur simultaneously. These two phenomena cannot be distinguished by observing the evolution of the axial pressure alone, as it decreases in both cases. #excipients #Excipress by ARMOR PHARMA #Pearlitol by Roquette Pharma Solutions #Vivapur by JRS PHARMA

Discover the cutting-edge advantages of combining lipids and polymers in extrusion processes! Learn more about how these advancements are shaping pharmaceutical manufacturing by checking out the #PBPWorldMeeting poster from Gattefossé Pharmaceuticals and Thermo Fisher Scientific. #pharmaceutical #excipients #innovation #extrusion

𝗘𝘅𝗰𝗶𝗽𝗶𝗲𝗻𝘁 𝗲𝗳𝗳𝗲𝗰𝘁𝘀 𝗼𝗻 𝘀𝘂𝗽𝗲𝗿𝘀𝗮𝘁𝘂𝗿𝗮𝘁𝗶𝗼𝗻, 𝗽𝗮𝗿𝘁𝗶𝗰𝗹𝗲 𝘀𝗶𝘇𝗲 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀, 𝗮𝗻𝗱 𝘁𝗵𝗲𝗿𝗺𝗼𝗱𝘆𝗻𝗮𝗺𝗶𝗰 𝗮𝗰𝘁𝗶𝘃𝗶𝘁𝘆 𝗼𝗳 𝗺𝘂𝗹𝘁𝗶𝗱𝗿𝘂𝗴 𝗮𝗺𝗼𝗿𝗽𝗵𝗼𝘂𝘀 𝗳𝗼𝗿𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻𝘀 Multidrug formulations enhance patient compliance and extend the life cycle of pharmaceutical products. To overcome solubility challenges for multidrug combinations, amorphous formulations are commonly used. However, the excipients for creating amorphous formulations are often selected without an understanding of their effects on the bioavailability of the drugs. In this context, we investigated the impact of three types of excipients (polymers, surfactants and amino acids) on the supersaturation and thermodynamic activity of multidrug amorphous formulations. Additionally, we studied the particle size dynamics of the colloidal phase formed as a result of liquid–liquid phase separation. Learn more here: https://lnkd.in/ehkCjR5G #excipients

𝗣𝗛𝗔𝗥𝗠𝗔𝗖𝗢𝗔𝗧® – 𝗘𝗮𝘀𝘆 𝘁𝗼 𝘂𝘀𝗲 𝗳𝗶𝗹𝗺 𝗰𝗼𝗮𝘁𝗶𝗻𝗴 𝗺𝗮𝘁𝗲𝗿𝗶𝗮𝗹 𝘁𝗵𝗮𝘁 𝗽𝗿𝗼𝘃𝗶𝗱𝗲𝘀 𝗮𝗻 𝗲𝘅𝗰𝗲𝗹𝗹𝗲𝗻𝘁 𝗳𝗶𝗻𝗶𝘀𝗵 Shin-Etsu Chemical supplies the various excipients for pharmaceutical industry and developed PHARMACOAT® in the 1960s during the early days of film coating and since then it has been the subject of a continuous development and quality improvement. The PHARMACOAT® grades are low viscous hypromellose substitution 2910 (also named as Hydroxy propyl methyl cellulose or HPMC). Hydroxypropoxy and methoxy groups are introduced on the cellulose backbone, resulting in a water-soluble cellulose derivative. Several viscosity grades are available as shown in the table below and are compliant with the pharmacopoeias from USA, Japan and Europe. SE Tylose GmbH & Co. KG #pharmaceutical #excipient #PHARMACOAT

𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗟𝗶𝗾𝘂𝗶𝘀𝗼𝗹𝗶𝗱 𝗣𝗲𝗹𝗹𝗲𝘁𝘀 𝗧𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 𝗳𝗼𝗿 𝗜𝗺𝗽𝗿𝗼𝘃𝗶𝗻𝗴 𝗗𝗶𝘀𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 𝗼𝗳 𝗣𝗼𝘀𝗮𝗰𝗼𝗻𝗮𝘇𝗼𝗹𝗲: 𝗔 𝗗𝗼𝗘 𝗕𝗮𝘀𝗲𝗱 𝗣𝗿𝗼𝗰𝗲𝘀𝘀 𝗢𝗽𝘁𝗶𝗺𝗶𝘇𝗮𝘁𝗶𝗼𝗻 The present investigation was aimed to formulate and evaluate liquisolid pellets of PSZ for improving its dissolution. Liquisolid pellets were prepared using #Transcutol® HP, #Neusilin® US2, and #Aerosil® 200 as non-volatile liquid, carrier, and coating materials respectively. A 32 full factorial design having excipient ratio (R) and spheronization speed as independent variables and the cumulative amount of drug dissolved at 135 min and 165 min as dependent variables were used for the process optimization. #pharmaceutical #excipients Gattefossé Pharmaceuticals Fuji Chemical Industries USA, Inc Evonik Health Care https://lnkd.in/eGncM2qH

𝗧𝗵𝗲 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁 𝗼𝗳 𝗮𝗻 𝗶𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝘃𝗲 𝗺𝗲𝘁𝗵𝗼𝗱 𝘁𝗼 𝗶𝗺𝗽𝗿𝗼𝘃𝗲 𝘁𝗵𝗲 𝗱𝗶𝘀𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 𝗽𝗲𝗿𝗳𝗼𝗿𝗺𝗮𝗻𝗰𝗲 𝗼𝗳 𝗿𝗶𝘃𝗮𝗿𝗼𝘅𝗮𝗯𝗮𝗻 Recent advancements in the formulation of solid dosage forms involving active ingredient-cyclodextrin complexes have garnered considerable attention in pharmaceutical research. While previous studies predominantly focused on incorporating these complexes into solid states, issues regarding incomplete inclusion prompted the exploration of novel methods. In this study, we aimed to develop an innovative approach to integrate liquid-state drug-cyclodextrin inclusion complexes into solid dosage forms. Our investigation centered on rivaroxaban, a hydrophobic compound practically insoluble in water, included in hydroxypropyl-β-cyclodextrin at a 1:1 molar ratio, and maintained in a liquid state.  #excipient #cyclodextrin

𝗘𝗳𝗳𝗲𝗰𝘁𝘀 𝗼𝗳 𝗼𝗺𝗶𝘁𝘁𝗶𝗻𝗴 𝘁𝗶𝘁𝗮𝗻𝗶𝘂𝗺 𝗱𝗶𝗼𝘅𝗶𝗱𝗲 𝗳𝗿𝗼𝗺 𝘁𝗵𝗲 𝗳𝗶𝗹𝗺 𝗰𝗼𝗮𝘁𝗶𝗻𝗴 𝗼𝗳 𝗮 𝗽𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹 𝘁𝗮𝗯𝗹𝗲𝘁 Recently, concerns have been raised about the safety of titanium dioxide (TiO2), a commonly used component of pharmaceutical film coatings. The European Union has recently prohibited the application of this material in the food industry, and it is anticipated that the same will happen in the pharmaceutical industry. For this reason, pharmaceutical manufacturers have to consider the possible impact of removing TiO2 from the film coating of tablets. In this paper, we present a case study of a commercially produced tablet where the film coating containing TiO2 was replaced with a coating using calcium carbonate (CaCO3) or with a transparent coating. The performance of the coatings was compared by measuring the moisture absorption rate and the dissolution profile of the tablets. #excipient #TiO2 #coating

Alteration of gel point of poloxamer 338 induced by pharmaceutical actives and excipients