👩🏻🔬Excited to share our latest research article 🧑🏻🔬
Dear Connections,
Excited to share that our latest research article, “Isomer engineering of benzofuran derived AIE luminogens: Synthesis, mechanochromism, pH responsive fluorescent switching, cell-imaging and Fe3+ sensing” has been published!
In this study, through isomeric engineering of benzofuran-derived AIE luminogens, we observed a remarkable shift in their photophysical properties. Integrating TPE into the benzofuran core produced a mechanofluorochromic luminogen, while modifying the side chain with TPE enhanced luminogenic performance and introduced cell-imaging capabilities.
Check out the full article
https://lnkd.in/dWQpKbUN
Abstract:
The influence of multiple factors often leads to the unexpected performances of the designed AIEgens. It is difficult to precisely conclude the influence of the substituted sites and role of isomers on the photophysical properties of the AIEgens which therefore brings uncertainty in the molecular design strategies. Isomer engineering of AIEgens is a less explored domain. There are only a few reports that substantiate the effects and positions of the substituents on the AIE properties. The present investigation explores two isomeric benzofuran-derived luminogens GBY-1 and GBY-4, both featuring a TPE moiety and showcasing AIE and AIEE properties respectively inherited from TPE. The isomeric effect resulting from TPE incorporation at different positions across benzofuran significantly influenced their photophysical properties, mechanofluorochromic properties, and AIE effect. Their distinctive luminogenic features were evident in mechanochromic property as well as in cancer cell imaging. GBY-1 was found to be uniformly dispersed in the cytoplasm, not co-localized with the nucleus, while GBY-4accumulated near the cell membrane. Furthermore, post-functionalization of one of the luminogens, GBY-1, derived another AIEgen, GBY-5 with a dramatic improvement in the PLQE along with its ability to selectively sense Fe3+ in aqueous environments, within a detection limit of 0.00035 mM.
I am thankful to my research supervisor Dr. Satyajit Saha for his constant guidance and encouragement.
I would like to acknowledge #SARTHI for providing financial support.
Congratulations to all authors.
#Research #Innovation #MaterialScience #AIE #Luminogens #sensing
ORISE Postdoctoral Research Associate at US Department of Agriculture (USDA) Agricultural Research Service (ARS), Fargo, USA| Senior Research Associate-Scientists' Pool Scheme of CSIR, IARI, New Delhi, India
7moCongratulations