Rolla V’s Post

Post COVID Erectile Dysfunction has been reported by many men who report difficulty obtaining and maintaining an erection. There are several factors that could be playing into this, and it may be difficult for doctors to determine the cause but they can offer medications like viagra. Viagra and similar medications can affect the heart, so it may not be appropriate for everyone, especially if you have cardiac complications from COVID or the vaccine. A possibility is neural inflammation affecting hormone production and absorption. Neuro COVID results in inflammation and dysfunction of the brain and nervous system and leads to conditions that disrupt multiple body systems including the organs, nerves, and tissues. Common symptoms include hormonal disruption, headaches, depression, anxiety, fatigue, and brain fog. This article explains neuro COVID and offers suggestions for interventions. https://lnkd.in/dpGzChzy Another factor can be adrenal fatigue related. The adrenal glands play an important role in a healthy immune system, but COVID-19 and other illnesses can cause adrenal insufficiency, a medical condition caused by chronic physical or mental stress that occurs when the adrenal glands are over worked and can’t make enough cortisol to keep up with the demand. It can be difficult to diagnose and is often missed. https://lnkd.in/eYHdDDFY Nitric oxide (NO) is a gas that plays a role in initiating and maintaining erections. It’s produced by most cells in the body, and activates enzymes in blood vessels that help with erections. However, the body produces less NO as people age. Research has found that nitric oxide plays a key role in facilitating erections by relaxing the vascular muscle that supplies your penis with blood when you’re sexually aroused. This increase in blood vessel diameter and blood flow is what allows your penis to stay firm and erect while you’re having sex. Some supplements, such as L-citrulline, L-arginine, and French maritime pine bark extract, may help increase NO levels in people with erectile dysfunction (ED). Seek medical attention if you experience dizziness or chest pain while taking NO. Here is an article about NO supplements by Dr. Kelly Brown. https://lnkd.in/e6swuqnk There are also other post COVID/long COVID sequelae like vascular inflammation and amyloid clotting/microclotting that could be going on, but that usually resolves within 3-6 months. There could be other possible issues, but these are a good starting point. NEED SUPPORT? Promedview coaches and advocates can help you: • Document your symptoms • Review your medical records • Find legal, medical, & mental health resources • Navigate your recovery Learn more at https://lnkd.in/dXBhFW8v #erectiledysfunction #longcoviderectiledysfunction #Longcovidmenshealth

Heart healthy behaviors may help reverse rapid cell aging. #cardiology #heart #hearthealth #heartcare #diet #excercise #health #healthtips #healthcare

Heart healthy behaviors may help reverse rapid cell aging. #cardiology #heart #hearthealth #heartcare #diet #excercise #health #healthtips #healthcare

Post COVID Erectile Dysfunction has been reported by many men who report difficulty obtaining and maintaining an erection. There are several factors that could be playing into this, and it may be difficult for doctors to determine the cause but they can offer medications like viagra. Viagra and similar medications can affect the heart, so it may not be appropriate for everyone, especially if you have cardiac complications from COVID or the vaccine. A possibility is neural inflammation affecting hormone production and absorption. Neuro COVID results in inflammation and dysfunction of the brain and nervous system and leads to conditions that disrupt multiple body systems including the organs, nerves, and tissues. Common symptoms include hormonal disruption, headaches, depression, anxiety, fatigue, and brain fog. This article explains neuro COVID and offers suggestions for interventions. https://lnkd.in/dpGzChzy Another factor can be adrenal fatigue related. The adrenal glands play an important role in a healthy immune system, but COVID-19 and other illnesses can cause adrenal insufficiency, a medical condition caused by chronic physical or mental stress that occurs when the adrenal glands are over worked and can’t make enough cortisol to keep up with the demand. It can be difficult to diagnose and is often missed. https://lnkd.in/eYHdDDFY Nitric oxide (NO) is a gas that plays a role in initiating and maintaining erections. It’s produced by most cells in the body, and activates enzymes in blood vessels that help with erections. However, the body produces less NO as people age. Research has found that nitric oxide plays a key role in facilitating erections by relaxing the vascular muscle that supplies your penis with blood when you’re sexually aroused. This increase in blood vessel diameter and blood flow is what allows your penis to stay firm and erect while you’re having sex. Some supplements, such as L-citrulline, L-arginine, and French maritime pine bark extract, may help increase NO levels in people with erectile dysfunction (ED). Seek medical attention if you experience dizziness or chest pain while taking NO. Here is an article about NO supplements by Dr. Kelly Brown. https://lnkd.in/e6swuqnk There are also other post COVID/long COVID sequelae like vascular inflammation and amyloid clotting/microclotting that could be going on, but that usually resolves within 3-6 months. There could be other possible issues, but these are a good starting point. NEED SUPPORT? Promedview coaches and advocates can help you: • Document your symptoms • Review your medical records • Find legal, medical, & mental health resources • Navigate your recovery Learn more at https://lnkd.in/dXBhFW8v #erectiledysfunction #longcoviderectiledysfunction #Longcovidmenshealth

𝐅𝐫𝐨𝐦 𝐭𝐡𝐞 𝐚𝐠𝐞 𝐨𝐟 𝟐𝟓, 𝐭𝐚𝐤𝐞 𝐜𝐨𝐧𝐭𝐫𝐨𝐥 𝐨𝐟 𝐲𝐨𝐮𝐫 𝐚𝐠𝐢𝐧𝐠! Aging is not linear; its mechanisms are in place many years before the appearance of its first signs. Aging begins when tissues and organs begin to lose function as a result of cell degradation. Some organs, such as the skin, see certain functions begin to decline, while others, such as the brain, are still developing. However, there is a consensus that aging begins between the ages of 25 and 35. Based on the evolution of 5 parameters (metabolism, bone structure, muscles, memory, sleep) in 4,263 people aged between 18 and 95, researchers have shown that aging is not linear, but progresses in 3 stages: 30, 60 and 80 (1). The mechanisms of aging are in place for a long time, sometimes decades, before the first signs of aging appear. The average age of the first consultation with anti-aging medicine is 45 - 50, i.e. the age of the established signs of aging. Based on experimental studies showing that anti-aging treatments, such as Metformin, are more beneficial if started early in life (2), some specialists are leaning towards early management of aging, as early as 25 - 30 years old, starting with a complete check-up. © AGE Breaker, updated 07 2024 [Glycation is one of the major causes of aging. Resulting from the fixation of sugars on the proteins constituting the organism, glycation generates toxic compounds that cause cellular aging. Glycation is particularly involved in metabolic disorders, skin aging and cognitive decline.] [AGE BREAKER, patented nutritional supplements, based on rosmarinic acid, recognized by aging specialists around the world for their properties to reverse the effects of glycation.] More on https://swll.to/CZY6yv1 #agebreaker #glycation #antiaging #longevitymedicine #preventivemedicine #preventivehealth #skinaging #4pmedicine #advancedglycationendproducts (1) : T. LEHALLIER, Benoit, GATE, David, SCHAUM, Nicholas, et al. Undulating changes in human plasma proteome profiles across the lifespan are linked to disease: Biomarkers (non‐neuroimaging): Novel biomarkers. Alzheimer's & Dementia, 2020, vol. 16, p. e043868. https://swll.to/eW74pW (2) : ANISIMOV, Vladimir N., BERSTEIN, Lev M., POPOVICH, Irina G., et al. If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice. Aging (Albany NY), 2011, vol. 3, no 2, p. 148. doi: 10.18632/aging.100273

The Age-NAD+ Connection: Understanding the Decline in NAD+ Levels with Aging One of the most intriguing facets of Nicotinamide Adenine Dinucleotide (NAD+) is its relationship with aging. As we grow older, NAD+ levels in our cells decline, leading to a host of age-related health issues. This article delves into why NAD+ levels decrease with age and what this means for our overall well-being. The Downward Trend: NAD+ and Aging Multiple studies have found a significant decline in NAD+ levels as organisms age. This decrease is evident in various tissues, including the brain, liver, and muscles. But why does this decline happen in the first place? The Role of DNA Damage One major factor is the accumulation of DNA damage over time, which requires repair mechanisms that consume NAD+. Metabolic Inefficiencies As we age, our metabolic processes become less efficient, leading to a reduced ability to regenerate NAD+ from its reduced form, NADH. Increased Enzymatic Consumption Certain enzymes, like CD38, which are more active in older organisms, break down NAD+, further contributing to its decline. Why Reduced NAD+ Levels Matter Impaired Cellular Functions The decline in NAD+ impairs cellular metabolism and energy production, affecting the cell's ability to perform its functions optimally. Increased Susceptibility to Disease Lower NAD+ levels have been associated with an increased risk of developing various diseases, including heart disease, diabetes, and neurodegenerative disorders. Accelerated Aging A decrease in NAD+ has been linked to signs of accelerated aging in animal models, from reduced muscle function to cognitive decline. Possible Interventions NAD+ Boosters Compounds like nicotinamide riboside and nicotinamide mononucleotide have shown promise in raising NAD+ levels in preliminary studies. Dietary and Lifestyle Changes Caloric restriction and exercise have also been shown to increase NAD+ levels, although more research is needed to confirm their effectiveness. Conclusion The decline in NAD+ levels as we age is more than just a biological footnote; it's a critical factor in aging and age-related diseases. Understanding this relationship opens up new avenues for interventions that could improve health span and potentially extend lifespan. https://lnkd.in/gYnQyxzH

The right balance of hormones is super important for breast health. A ton of hormones are involved in the balance of hormones, including estrogen, progesterone, testosterone, cortisol, DHEA, and vitamin D.  A lot of the hormones that are heavily involved in staying healthy in general are also hugely critical for breast health.  In my blog post this week, I talk about some of the roles that these hormones can play in keeping your breasts healthy.  https://lnkd.in/gqrJtR9

This Month is Traumatic Brain Injury awareness Month. Who knew! Here is my contribution to the discussion on TBI treatments. --HBOT and Nutritional Strategies for TBI Recovery-- Traumatic Brain Injury (TBI) impacts cognitive function, mood, and life quality. We explore HBOT and nutrition's role in TBI recovery, shedding light on healing, brain protection, and neurogenesis. --Understanding TBI -- TBI results from external force, causing brain damage and lasting cognitive effects. Effective treatments are limited, demanding innovative approaches for recovery. --Harnessing HBOT-- HBOT increases oxygen levels, promotes tissue repair, and reduces inflammation. It offers hope for improved TBI outcomes. --Nutrition's Role-- Omega-3s, antioxidants, and micronutrients support brain health and neurogenesis. Balanced diets aid brain repair and regeneration. --Optimizing Micronutrients-- Addressing deficiencies enhances neurological function and recovery, crucial for TBI patients. Correct Fats Importance Omega-3s maintain brain integrity, reduce inflammation, and support synaptic plasticity, crucial for TBI recovery. Empowering Recovery Personalized treatment plans empower patients, advancing TBI treatment and improving outcomes. In conclusion, HBOT and nutrition offer promising avenues for TBI recovery, enhancing life quality and promoting healing.

Some nostalgia 20 years after… Diabetes and obesity. Back in October 2004 while at Johnson & Johnson, I published with colleagues from the University of Minnesota, Harvard, Mayo Clinic and East Carolina University a landmark article in the Journal of the American Medical Association (JAMA). Our research, titled Bariatric surgery: a systematic review and meta-analysis Clearly showed that weight loss surgery, and in particular bypass surgery, resolves Diabetes Type-2, Obstructive Sleep Apnea, Hypertension and Hyper-cholesterolemia in >90% of patients. Potential to resolve and even cure diabetes was what got me most intrigued when I began this project and I became extremely passionate as time went by. We and others had estimated that the underlying mechanism for the impact on diabetes is through regulation of gut-related hormones which govern glucose metabolism (one such hormone is the now famous GLP-1). It was obvious that further research should focus on this endocrine system as a target for obesity AND diabetes pharmaceutical research. The publication, which has since been cited by over 9,000 research articles prompted my then employer J&J to set up its bariatric (obesity surgery) division and went on to play a part in massive investments by industry, venture capital and health systems in drugs and devices that treat obesity and diabetes-II as one related entity. It also helped us explain that morbid obesity is a legitimate disease, which deserves and requires treatment with device, drug, advocacy and reimbursement and that significant AND sustained improvement in obesity leads to dramatic health benefits. It’s been very interesting (and gratifying!) to see what happened to this area since. especially when folks I know are now taking Wegovy, Ozempic, Zepbound or Mounjaro - GLP-1 agonists, to treat their diabetes, obesity and sleep apnea with many more GLP pathway related drugs in the pipeline!

Ophthopedia Update:The Association Between Intermittent Fasting and Glaucoma: Précis: Intermittent fasting was not associated with a decreased risk of glaucoma diagnosis overall. Objective: To examine the association between intermittent fasting (“breakfast skipping”) and glaucoma in the National Health and Nutrition Examination Survey (NHANES). Patients and Methods: Retrospective, cross-sectional study of adult participants of the 2005–2008 NHANES aged 40 years and older. Intermittent fasting was defined as skipping breakfast on both days of the NHANES dietary interview. Glaucoma was defined by (1) self-reported glaucoma diagnosis, (2) cup-to-disc (CDR) ≥0.6 in at least one eye, and (3) possible, probable, or definite glaucoma based on clinical judgment of retinal imaging of individuals with CDR ≥0.6 in at least one eye. Covariates included age, sex, race/ethnicity, body mass index, blood pressure, and waist circumference. χ2 and Fisher exact test were used for categorical variables and the t test for continuous variables. All data were weighted based on the NHANES multistage sampling design. Results: The population included 7081 individuals 40 years or older, of whom 946 (13.4%) reported skipping breakfast on both interview days; 482 (6.8%) individuals self-reported glaucoma diagnosis, 549 (7.8%) individuals had glaucoma based on CDR ≥0.6, and 343 (6.0%) individuals had glaucoma based on clinical judgment. Diagnosis of glaucoma by all definitions was associated with older age and black or Latinx/Hispanic ethnicity (P = 0.004) but was not associated with intermittent fasting status (P = 0.151). Conclusions: In the 2005–2008 NHANES population, intermittent fasting, defined as breakfast skipping, was not associated with decreased risk of glaucoma diagnosis overall. Further studies are needed to examine the potential effects of intermittent fasting on glaucoma risk. #Ophthalmology #Eye #Ophthotwitter